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    DRUG CLASS:

    BCMA-targeted antibody-drug conjugate

    Related drugs:
    1d
    GEM-BELACOMBOS: Study to Evaluate Efficacy and Safety of Belantamab-based Combinations for Relapsed Multiple Myeloma (clinicaltrials.gov)
    P=N/A, N=100, Not yet recruiting, PETHEMA Foundation
    New trial
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    B2M (Beta-2-microglobulin)
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    bortezomib • dexamethasone • pomalidomide • Blenrep (belantamab mafodotin-blmf)
    12d
    DREAMM-16: Study of Alternative and Approved Dosing Regimens of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=120, Not yet recruiting, GlaxoSmithKline
    New P2 trial
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    bortezomib • dexamethasone • Blenrep (belantamab mafodotin-blmf)
    13d
    BELAMI: A Multicenter Study of Belantamab Mafodotin and Mezigdomide in Patients With Relapsed Multiple Myeloma (clinicaltrials.gov)
    P2, N=44, Not yet recruiting, Centre Hospitalier Universitaire de Saint Etienne
    New P2 trial
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    Blenrep (belantamab mafodotin-blmf) • mezigdomide (CC-92480)
    15d
    A Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic Impairment (clinicaltrials.gov)
    P1, N=20, Not yet recruiting, GlaxoSmithKline
    New P1 trial
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    bortezomib • dexamethasone • Blenrep (belantamab mafodotin-blmf)
    23d
    BELI(E)VE: Combination Treatment of Belantamab Mafodotin and Venetoclax in Treatment of Relapsed and Refractory t(11;14) Multiple Myeloma (clinicaltrials.gov)
    P1/2, N=45, Recruiting, Universitätsklinikum Hamburg-Eppendorf | Trial completion date: Dec 2026 --> Dec 2028 | Trial primary completion date: Nov 2026 --> Apr 2027
    Trial completion date • Trial primary completion date
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    Chr t(11;14)
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    Venclexta (venetoclax) • Blenrep (belantamab mafodotin-blmf)
    28d
    Novel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma (clinicaltrials.gov)
    P1/2, N=24, Active, not recruiting, Yale University | Recruiting --> Active, not recruiting
    Enrollment closed
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    Empliciti (elotuzumab) • Blenrep (belantamab mafodotin-blmf)
    1m
    GEM-BELMA: Study of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to Lenalidomide (clinicaltrials.gov)
    P1/2, N=60, Active, not recruiting, PETHEMA Foundation | Recruiting --> Active, not recruiting
    Enrollment closed
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    lenalidomide • carfilzomib • dexamethasone • Blenrep (belantamab mafodotin-blmf)
    1m
    Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis (clinicaltrials.gov)
    P1/2, N=37, Recruiting, University of Texas Southwestern Medical Center | Trial completion date: Sep 2026 --> Sep 2027 | Trial primary completion date: Mar 2026 --> Mar 2027
    Trial completion date • Trial primary completion date
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    Blenrep (belantamab mafodotin-blmf)
    1m
    DREAMM 5: Platform Study of Belantamab Mafodotin as Monotherapy and in Combination With Anti-cancer Treatments in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) (clinicaltrials.gov)
    P1/2, N=208, Active, not recruiting, GlaxoSmithKline | Phase classification: P2 --> P1/2
    Phase classification
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    lenalidomide • Jemperli (dostarlimab-gxly) • dexamethasone • pomalidomide • Sarclisa (isatuximab-irfc) • Blenrep (belantamab mafodotin-blmf) • Ogsiveo (nirogacestat) • feladilimab (GSK3359609) • GSK3174998
    1m
    DREAMM 14: Study to Investigate Alternative Dosing Regimens of Belantamab Mafodotin in Participants With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=177, Active, not recruiting, GlaxoSmithKline | Completed --> Active, not recruiting
    Enrollment closed
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    Blenrep (belantamab mafodotin-blmf)
    1m
    DREAMM-15: A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM) (clinicaltrials.gov)
    P2, N=200, Recruiting, GlaxoSmithKline | Not yet recruiting --> Recruiting | Initiation date: Jan 2026 --> Apr 2026
    Enrollment open • Trial initiation date
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    bortezomib • carfilzomib • dexamethasone • pomalidomide • Blenrep (belantamab mafodotin-blmf)
    2ms
    DREAMM 7: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov)
    P3, N=494, Active, not recruiting, GlaxoSmithKline | Trial completion date: Jun 2026 --> Jun 2028
    Trial completion date
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    bortezomib • Darzalex (daratumumab) • dexamethasone • Blenrep (belantamab mafodotin-blmf)