News - CA9 expression

11ms

Two-photon photosensitizer for specific targeting and induction of tumor pyroptosis to elicit systemic immunity-boosting anti-tumor therapy. (PubMed, Biomaterials)

Through comprehensive immune assessments, TPSS under two-photon laser irradiation effectively activates both the innate and adaptive immune systems, efficiently suppressing the proliferation of distant metastatic tumors, underscoring its considerable therapeutic potential. Collectively, this study provides a viable strategy to overcome the limitations of PDT, highlighting the prospects of two-photon excitation photosensitizers.

11 months ago

Journal

CA9 (Carbonic anhydrase 9)

CA9 overexpression • CA9 expression

11ms

Study of urine-based mRNA biomarkers for early detection of nonmuscle invasive bladder cancer (NMIBC). (PubMed, Urol Oncol)

These results emphasize the potential application of urine mRNA profiling in the early diagnosis of NMIBC and provide new insights into the molecular mechanisms involved.

11 months ago

Journal

TOP2A (DNA topoisomerase 2-alpha) • CA9 (Carbonic anhydrase 9) • CD24 (CD24 Molecule) • CDK1 (Cyclin-dependent kinase 1) • CEP55 (Centrosomal Protein 55) • UBE2C (Ubiquitin Conjugating Enzyme E2 C)

CA9 expression • TOP2A expression

11ms

Targeting Siglec-E facilitates tumor vaccine-induced antitumor immunity in renal carcinoma. (PubMed, J Immunother Cancer)

Our results indicate that targeting Siglec-E enhances the therapeutic efficacy of Ad-CAIX against renal carcinoma, providing a promising therapeutic option for solid tumors.

11 months ago

Journal • IO biomarker

CD8 (cluster of differentiation 8) • CA9 (Carbonic anhydrase 9) • ITGAX (Integrin Subunit Alpha X)

CA9 expression

11ms

Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway. (PubMed, Diagn Pathol)

The results of our study further support the hypothesis that the pathogenesis of JGCT may be driven by activation of the PIK3/AKT/mTOR pathway. These findings could potentially have future therapeutic implications, as treatment strategies targeting the PTEN/mTOR pathways are currently under investigation.

11 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • AR (Androgen receptor) • ARID1A (AT-rich interaction domain 1A) • TERT (Telomerase Reverse Transcriptase) • SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) • WT1 (WT1 Transcription Factor) • NKX2-1 (NK2 Homeobox 1) • CA9 (Carbonic anhydrase 9) • MUC4 (Mucin 4, Cell Surface Associated) • SALL4 (Spalt Like Transcription Factor 4) • CD99 (CD99 Molecule) • EP400 (E1A Binding Protein P400) • GATA3 (GATA binding protein 3) • NAPSA (Napsin A Aspartic Peptidase) • FOXL2 (Forkhead Box L2)

PD-L1 expression • HER-2 negative • HER-2 expression • PTEN expression • AKT1 mutation • TERT mutation • TP53 expression • MUC4 expression • CA9 expression

11ms

Upregulation of RCN2 accelerates tumor progression and indicates poor prognosis in OSCC. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol)

Our study revealed that RCN2 promotes tumor progression by activating PKA/AKT/mTORC signaling, which suggests that RCN2 may serve as a potential target for OSCC treatment.

11 months ago

Journal

CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CA9 (Carbonic anhydrase 9)

CA9 overexpression • CA9 expression

11ms

PHPS1 enhances PD-L1 serine phosphorylation by regulating ROS/SHP-2/AMPK activity to promote apoptosis of oral squamous cell carcinoma cells (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)

PHPS1 can enhance PD-L1 serine phosphorylation by regulating SHP-2/AMPK activity to promote apoptosis of oral squamous cell carcinoma cells under hypoxic conditions.

11 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

HIF1A (Hypoxia inducible factor 1, alpha subunit) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CA9 (Carbonic anhydrase 9) • CASP3 (Caspase 3) • CASP8 (Caspase 8)

BAX expression • HIF1A expression • CA9 expression • AMPK expression

12ms

A commentary: New carbonic anhydrase IX-targeted probes for imaging hypoxic tumors (PubMed, Bull Cancer)

combined acetazolamide (AZA) to target carbonic anhydrase IX (CA IX) with two tyrosine-derived Mn(II)-ethylenediaminetetraacetic acid chelates (TyEDTA) on a rigid triazine (TA) scaffold...Using CA IX as a biomarker of hypoxia, Cao et al. have thus illustrated a practical strategy for the development of novel imaging probes for specific regions of hypoxia in a tumor of interest.

12 months ago

Journal

CA9 (Carbonic anhydrase 9)

CA9 expression

acetazolamide

12ms

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX. (PubMed, Elife)

The lead inhibitors reached 2 pM affinity, the highest among known CAIX inhibitors. The strategy could be used for any disease drug target protein bearing a His residue in the vicinity of the active site.

12 months ago

Journal

CA9 (Carbonic anhydrase 9)

CA9 expression

12ms

Aggressive renal cell carcinoma with somatic BRCA2 mutation-an emerging entity? A case report with literature review. (PubMed, Virchows Arch)

This unusual co-expression of the commonly used IHC stains during the workup of RCC could serve as a potential diagnostic pitfall. Although very rare, it is important for pathologists to be aware of this form of RCC due to its aggressive clinical behavior, possibility of a germline mutation, and current therapeutic options for tumors with BRCA2 mutation.

12 months ago

Review • Journal • BRCA Biomarker

BRCA2 (Breast cancer 2, early onset) • CA9 (Carbonic anhydrase 9) • MME (Membrane Metalloendopeptidase) • PAX8 (Paired box 8)

BRCA2 mutation • CA9 expression

12ms

Elucidation of Dysregulated Pathways Associated With Hypoxia in Oestrogen Receptor-Negative Breast Cancer. (PubMed, Cancer Med)

Cytoplasmic CAIX was independently associated with poor prognosis in ER- BC. Gene expression profiles shed light on the pathways and genes associated with hypoxia in ER- BC. In node-negative patients, SPNS2 was of particular interest.

12 months ago

Journal

ER (Estrogen receptor) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • CA9 (Carbonic anhydrase 9) • CEACAM6 (CEA Cell Adhesion Molecule 6) • MMP7 (Matrix metallopeptidase 7) • SPHK1 (Sphingosine Kinase 1)

ER negative • CA9 expression

12ms

Targeting CA9 restricts pancreatic cancer progression through pH regulation and ROS production. (PubMed, Cell Oncol (Dordr))

Collectively, our data illustrate that CA9 has a direct regulatory role in pHi homeostasis and ROS production, providing a potential therapeutic target for PDAC treatment.

12 months ago

Journal

CA9 (Carbonic anhydrase 9) • FUS (FUS RNA Binding Protein) • NOX4 (NADPH Oxidase 4)

CA9 expression

1year

Disruption of the Physical Interaction Between Carbonic Anhydrase IX and the Monocarboxylate Transporter 4 Impacts Lactate Transport in Breast Cancer Cells. (PubMed, Int J Mol Sci)

Finally, X-ray crystallographic studies highlight unique interactions between BGal2C and a CAIX-mimic that are not observed within the CAII active site and which may underlie the strong specificity of BGal2C for CAIX. These studies demonstrate the utility of a novel sulfonamide in interfering with elevated proton and lactate flux, a hallmark of many solid tumors.

1 year ago

Journal

CA9 (Carbonic anhydrase 9) • BSG (Basigin (Ok Blood Group))

CA9 expression