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    DRUG CLASS:

    β-catenin inhibitor

    Related drugs:
    1d
    NUP62 promotes breast cancer progression and inhibits ferroptosis by stabilizing NRF2 in a KEAP1-dependent way. (PubMed, iScience)
    In vivo, eribulin or NUP62 silencing significantly suppressed tumor growth in xenograft models. Our findings establish the NUP62-KEAP1-NRF2 axis as a master regulator of ferroptosis in BC, positioning eribulin as a promising therapeutic agent for NUP62-high tumors.
    Journal
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    KEAP1 (Kelch Like ECH Associated Protein 1) • NUP62 (Nucleoporin 62)
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    Halaven (eribulin mesylate)
    5d
    Safety and Antitumor Activity of Farletuzumab Ecteribulin in Patients With NSCLC: Phase I Expansion Results. (PubMed, JTO Clin Res Rep)
    FZEC demonstrated modest antitumor activity, and observed AEs were generally manageable in patients with heavily pretreated NSCLC. NCT03386942.
    P1 data • Journal
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    FOLR1 ( Folate receptor alpha )
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    FOLR1 expression
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    Halaven (eribulin mesylate) • farletuzumab ecteribulin (MORAb-202)
    9d
    Role of the cross-regulation between Wnt pathway activation and androgen receptor signaling in prostate cancer treatment resistance. (PubMed, Cell Death Differ)
    Targeting β-catenin interactions with co-activators p300/CBP using selective inhibitors (IQ-1 and ICG-001) effectively mitigated Wnt-driven ARSI resistance, restoring sensitivity to therapy in preclinical models...The identified Wnt signature holds potential as a biomarker for predicting and monitoring therapeutic outcomes. Concurrent targeting of AR and Wnt signaling represents a promising strategy to overcome treatment resistance, particularly in patients with Wnt-activating mutations.
    Journal
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    RNF43 (Ring Finger Protein 43) • ZNRF3 (Zinc And Ring Finger 3)
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    foscenvivint (PRI724)
    14d
    MBC-EA: A Multicenter, Single-Arm, Phase II Exploratory Study of Eribulin in Combination With Anlotinib for HER2-Negative Recurrent/Metastatic Breast Cancer Previously Treated With Antibody-Drug Conjugates (clinicaltrials.gov)
    P2, N=52, Recruiting, Sun Yat-sen University
    New P2 trial
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    HER-2 (Human epidermal growth factor receptor 2)
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    HER-2 negative
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    Focus V (anlotinib) • Halaven (eribulin mesylate)
    26d
    JAZMINE: Phase Ib/II Study of Zanidatamab Plus Tucatinib and Chemotherapy in HER2-Positive Advanced Breast Cancer (clinicaltrials.gov)
    P1/2, N=24, Not yet recruiting, MedSIR
    New P1/2 trial
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    HER-2 positive • HER-2 amplification
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    capecitabine • Halaven (eribulin mesylate) • Tukysa (tucatinib) • Ziihera (zanidatamab-hrii)
    26d
    CSF1R Inhibition with Chemotherapy Relieves Systemic Immune Suppression in Patients with Metastatic Triple-Negative Breast Cancer and Boosts anti-PD-1 Efficacy in Transgenic Mammary Tumors. (PubMed, Clin Cancer Res)
    These clinical and preclinical findings provide rationale for therapies to increase therapeutic index of aPD-1 therapy by diminishing presence of T cell-suppressive myelomonocytic cells to improve outcomes for patients with refractory disease.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule)
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    Halaven (eribulin mesylate) • Turalio (pexidartinib)
    1m
    Eribulin Mesylate-based Therapy in Patients With Advanced HER2-negative Breast Cancer Previously Treated With ADC (clinicaltrials.gov)
    P=N/A, N=400, Not yet recruiting, Fudan University
    New trial • Real-world evidence
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    HER-2 (Human epidermal growth factor receptor 2)
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    HER-2 negative
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    Halaven (eribulin mesylate)
    1m
    SWOG S1937: Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer (clinicaltrials.gov)
    P3, N=184, Active, not recruiting, National Cancer Institute (NCI) | Recruiting --> Active, not recruiting
    Enrollment closed
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    gemcitabine • paclitaxel • docetaxel • Halaven (eribulin mesylate) • Trodelvy (sacituzumab govitecan-hziy)
    1m
    Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma (clinicaltrials.gov)
    P1/2, N=126, Recruiting, HonorHealth Research Institute
    New P1/2 trial
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    BRAF (B-raf proto-oncogene)
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    MSI-H/dMMR • BRAF mutation • RAS wild-type
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    tegavivint (BC2059)
    1m
    Targeting phosphodiesterase 10A disrupts MAPK signaling pathways in the tumor microenvironment to unleash antitumor immunity. (PubMed, bioRxiv)
    Mechanistically, ADT-030 disrupts multiple components of the mitogen-activated protein kinase (MAPK) signaling network in both tumor cells and MDSCs, leading to induction of apoptosis in these populations. These findings highlight the multi-faceted impact of PDE10A inhibition as a therapeutic strategy that not only disrupts tumor-intrinsic oncogenic signaling to inhibit tumor progression but also reshapes the tumor immune microenvironment to unleash antitumor immunity.
    Journal
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    CD8 (cluster of differentiation 8) • BATF3 (Basic Leucine Zipper ATF-Like Transcription Factor 3)
    1m
    SABINA: PIK3CA/PTEN-altered Advanced Breast Cancer Treated With MEN1611 Monotherapy or in Combination With Eribulin (clinicaltrials.gov)
    P2, N=14, Active, not recruiting, MedSIR | Recruiting --> Active, not recruiting
    Enrollment closed • First-in-human
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    HER-2 (Human epidermal growth factor receptor 2) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • PTEN (Phosphatase and tensin homolog)
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    HER-2 positive • HR positive • HER-2 negative • PIK3CA mutation • HR positive + HER-2 negative
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    Halaven (eribulin mesylate) • izorlisib (MEN1611)
    2ms
    Study of E7386 in Participants With Selected Advanced Neoplasms (clinicaltrials.gov)
    P1, N=60, Active, not recruiting, Eisai Inc. | Trial completion date: Mar 2026 --> Mar 2027 | Trial primary completion date: Mar 2026 --> Mar 2027
    Trial completion date • Trial primary completion date
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1)
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    E7386