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    DRUG CLASS:

    CCR4 receptor antagonist

    Related drugs:
    5d
    The evolving landscape of regulatory T cells in leukemia: from mechanisms to advanced immunotherapeutic strategies. (PubMed, Front Immunol)
    A significant portion of this review examines the evolving therapeutic landscape, scrutinizing Treg-depleting antibodies (e.g., mogamulizumab, RG6292), immunomodulatory small molecules (venetoclax, hypomethylating agents, TKIs), and the challenges Tregs pose to cellular therapies. Finally, we discuss novel strategies to circumvent Treg-mediated resistance, offering a perspective on restoring anti-leukemic immunity.
    Review • Journal • IO biomarker
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    CD73 (5'-Nucleotidase Ecto) • CCR4 (C-C Motif Chemokine Receptor 4) • IL2RA (Interleukin 2 receptor, alpha) • CD4 (CD4 Molecule) • CCL2 (Chemokine (C-C motif) ligand 2) • FOXP3 (Forkhead Box P3) • CCL22 (C-C Motif Chemokine Ligand 22) • ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1)
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    IL2RA expression
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    Venclexta (venetoclax) • Poteligeo (mogamulizumab-kpkc) • vopikitug (RG6292)
    29d
    Efficacy and safety of mogamulizumab in Sézary syndrome with concomitant Crohn's disease. (PubMed, Dermatol Reports)
    By enhancing antibody-dependent cellular cytotoxicity, mogamulizumab selectively depletes CCR4-positive malignant lymphocytes and has demonstrated significant clinical activity in advanced CTCL, including in patients refractory to multiple prior therapies. [...].
    Journal
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    CCR4 (C-C Motif Chemokine Receptor 4)
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    Poteligeo (mogamulizumab-kpkc)
    1m
    Pembrolizumab and Mogamulizumab in Advanced-stage, Relapsed/Refractory Cutaneous T-cell Lymphomas (clinicaltrials.gov)
    P2, N=23, Recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Apr 2027 --> Dec 2027 | Trial primary completion date: Apr 2026 --> Dec 2026
    Trial completion date • Trial primary completion date
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    Keytruda (pembrolizumab) • Poteligeo (mogamulizumab-kpkc)
    1m
    HTLV-1-Driven Clonal Evolution and Immune Escape in Adult T-Cell Leukaemia: From Viral Persistence to Therapeutic Failure. (PubMed, Rev Med Virol)
    Despite the use of antiviral therapies and targeted monoclonal antibodies, therapeutic failure is common due to genomic instability-specifically TP53 mutations compromising Zidovudine/Interferon efficacy and CCR4 antigenic variations leading to mogamulizumab resistance. This review delineates the multi-step journey of HTLV-1-driven clonal evolution and evaluates the molecular barriers to effective clinical management.
    Review • Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • TP53 (Tumor protein P53) • CCR4 (C-C Motif Chemokine Receptor 4) • CD4 (CD4 Molecule)
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    TP53 mutation • PD-L1 overexpression
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    Poteligeo (mogamulizumab-kpkc)
    2ms
    New and Emerging Drug Reactions. (PubMed, Dermatol Clin)
    In this article, we discuss the clinical and histopathologic findings of cutaneous adverse reactions to newer medications, including those recently approved to treat inflammatory skin diseases, such as dupilumab for atopic dermatitis and IL-12/-23 and IL-23 specific inhibitors for psoriasis, as well as those with oncologic indications, including immune checkpoint inhibitors, mogamulizumab, and enfortumab vedotin.
    Review • Journal
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    IL23A (Interleukin 23 Subunit Alpha)
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    Padcev (enfortumab vedotin-ejfv) • Poteligeo (mogamulizumab-kpkc) • Dupixent (dupilumab)
    4ms
    BK polyomavirus-associated progressive multifocal leukoencephalopathy following mogamulizumab therapy for erythrodermic mycosis fungoides. (PubMed, Front Cell Infect Microbiol)
    This is the first documented case of BKPyV-associated PML in a Mogamulizumab-treated patient. These findings highlight intra-host heterogeneity at the protein level, possibly reflecting compartment-specific viral evolution, and underscore the need for vigilant BKPyV and JCPyV monitoring during Mogamulizumab treatment.
    Journal
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    CCR4 (C-C Motif Chemokine Receptor 4)
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    Poteligeo (mogamulizumab-kpkc)
    4ms
    Efficacy and tolerability of mogamulizumab in mycosis fungoides and Sézary Syndrome: a monocentric retrospective study. (PubMed, Front Oncol)
    The observed median overall survival (OS) was 11.5 months, with 1 reported death due to septic shock in a patient who underwent salvage allo-HSCT after mogamulizumab failure. The results of this study reaffirm the efficacy of Mogamulizumab therapy for patients with Mycosis Fungoides and Sézary Syndrome in a real-world setting, which involves treatment decisions that must often consider patient heterogeneity, comorbidities, and prior lines of therapy.
    Retrospective data • Journal
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    CCR4 (C-C Motif Chemokine Receptor 4)
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    Poteligeo (mogamulizumab-kpkc)
    4ms
    Chemokine Networks in Cutaneous T Cell Lymphoma: Tumor Microenvironment Remodeling and Therapeutic Targets. (PubMed, Curr Issues Mol Biol)
    Therapeutically, agents targeting chemokine pathways, most notably the CCR4 monoclonal antibody Mogamulizumab, have demonstrated clinical efficacy, while emerging inhibitors of CCR6, CCR5, and CXCR4 offer promising avenues for intervention. We further highlight how recent single-cell and other high-dimensional omics studies refine cell-type-specific chemokine sources and receptor expression, enabling more precise mapping of chemokine-driven intercellular communication programs in CTCL TME remodeling and better prioritization of therapeutic targets and biomarkers.
    Review • Journal • IO biomarker
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    CXCR4 (Chemokine (C-X-C motif) receptor 4) • CCR4 (C-C Motif Chemokine Receptor 4) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CD4 (CD4 Molecule) • CCL19 (C-C Motif Chemokine Ligand 19) • CCR7 (Chemokine (C-C motif) receptor 7) • CCL2 (Chemokine (C-C motif) ligand 2) • CCL21 (C-C Motif Chemokine Ligand 21) • CCL22 (C-C Motif Chemokine Ligand 22) • CCL27 (C-C Motif Chemokine Ligand 27) • CCR2 (C-C Motif Chemokine Receptor 2) • CCR8 (C-C Motif Chemokine Receptor 8) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • CXCR5 (C-X-C Motif Chemokine Receptor 5) • CCR6 (C-C Motif Chemokine Receptor 6)
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    Poteligeo (mogamulizumab-kpkc)
    5ms
    Pembrolizumab and Mogamulizumab in Advanced-stage, Relapsed/Refractory Cutaneous T-cell Lymphomas (clinicaltrials.gov)
    P2, N=23, Recruiting, University of Michigan Rogel Cancer Center | Trial completion date: Dec 2026 --> Apr 2027 | Trial primary completion date: Dec 2025 --> Apr 2026
    Trial completion date • Trial primary completion date
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    Keytruda (pembrolizumab) • Poteligeo (mogamulizumab-kpkc)
    6ms
    FIL_MOGA: Real World Experience With Mogamulizumab in the Treatment of Cutaneous T-cell Lymphoma (clinicaltrials.gov)
    P=N/A, N=100, Completed, Fondazione Italiana Linfomi - ETS | Recruiting --> Completed | N=150 --> 100
    Trial completion • Enrollment change • Real-world evidence
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    Poteligeo (mogamulizumab-kpkc)
    6ms
    Anti-HER2×CCR4 bispecific antibody enhances antitumor immunity in advanced HER2-positive tumors by chemotaxis blockade and depletion of tumor-associated Tregs, without inducing systemic toxicity. (PubMed, J Immunother Cancer)
    XL-11 mediates potent antitumor immunity in advanced HER2+ tumors while avoiding reducing Tregs throughout the body. XL-11 also acts synergistically with anti-PD-1 therapy, and exhibits favorable stability and PK supporting clinical translation. This work advances Treg-targeted therapies in HER2+ tumors and overcomes the therapeutic limitations of mogamulizumab.
    Journal
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • CCR4 (C-C Motif Chemokine Receptor 4)
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    HER-2 positive • HER-2 expression • EGFR positive
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    Poteligeo (mogamulizumab-kpkc)
    6ms
    Phototherapy and Mogamulizumab in Early Stage MF (PLIGHT) (clinicaltrials.gov)
    P1, N=20, Suspended, H. Lee Moffitt Cancer Center and Research Institute | Recruiting --> Suspended
    Trial suspension
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    CD7 (CD7 Molecule)
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    Poteligeo (mogamulizumab-kpkc)