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    DRUG CLASS:

    CD25-targeted antibody-drug conjugate

    Related drugs:
    13d
    Phase 1 Study of PF-08046033 in Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=250, Not yet recruiting, Pfizer
    New P1 trial • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    1m
    A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors (clinicaltrials.gov)
    P1, N=11, Terminated, Pfizer | Active, not recruiting --> Terminated; The trial was terminated for strategic reasons. The decision was not based on any safety and/or efficacy concerns.
    Trial termination
    3ms
    A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies (clinicaltrials.gov)
    P1, N=9, Active, not recruiting, Pfizer | Recruiting --> Active, not recruiting | N=399 --> 9 | Trial completion date: Sep 2029 --> Apr 2026 | Trial primary completion date: Sep 2028 --> Mar 2026
    Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Zumrad (sasanlimab)
    7ms
    A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors (clinicaltrials.gov)
    P1, N=11, Active, not recruiting, Pfizer | Recruiting --> Active, not recruiting | N=185 --> 11 | Trial completion date: Jun 2030 --> Feb 2026 | Trial primary completion date: Jun 2029 --> Feb 2026
    Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date
    7ms
    A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers (clinicaltrials.gov)
    P1, N=6, Active, not recruiting, Pfizer | Recruiting --> Active, not recruiting | N=220 --> 6 | Trial completion date: Apr 2029 --> Feb 2026 | Trial primary completion date: Jan 2029 --> Feb 2026
    Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date
    |
    Zumrad (sasanlimab)
    11ms
    A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies (clinicaltrials.gov)
    P1, N=399, Recruiting, Pfizer | Not yet recruiting --> Recruiting | Trial completion date: Feb 2029 --> Jul 2029 | Trial primary completion date: Feb 2028 --> Jul 2028
    Enrollment open • Trial completion date • Trial primary completion date
    |
    Zumrad (sasanlimab)
    11ms
    A Study to Learn About the Study Medicine Called PF-08046031 in Advanced Melanoma and Other Solid Tumors (clinicaltrials.gov)
    P1, N=185, Recruiting, Pfizer | Not yet recruiting --> Recruiting
    Enrollment open
    11ms
    A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers. (clinicaltrials.gov)
    P1, N=220, Recruiting, Pfizer | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Zumrad (sasanlimab)
    11ms
    A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies (clinicaltrials.gov)
    P1, N=399, Not yet recruiting, Pfizer
    New P1 trial
    |
    Zumrad (sasanlimab)
    12ms
    PF-08046032: A novel, investigational CD25-directed antibody-drug conjugate optimized for selective depletion of regulatory T cells in advanced malignant tumors. (PubMed, Mol Cancer Ther)
    Lastly, PF-08046032 was well-tolerated in non-human primates and mitigated the persistent depletion of peripheral blood Treg that was observed with a high affinity anti-CD25 ADC comparator, demonstrating the safety benefit of a detuned affinity ADC format. PF-08046032 represents an innovative therapeutic approach for depletion of intratumoral Tregs that may offer an improved safety profile and efficacy over traditional Treg depleting agents.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IL2RA (Interleukin 2 receptor, alpha) • IL2 (Interleukin 2)
    |
    IL2RA expression
    1year
    A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers. (clinicaltrials.gov)
    P1, N=220, Not yet recruiting, Pfizer
    New P1 trial
    |
    Zumrad (sasanlimab)
    1year
    This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1. (clinicaltrials.gov)
    P3, N=714, Not yet recruiting, Pfizer | Initiation date: Jan 2025 --> May 2025
    Trial initiation date
    |
    Keytruda (pembrolizumab) • sigvotatug vedotin (PF-08046047)