chlorogenic acid

In-vitro investigations demonstrated that, FhME exhibited notable α-glucosidase inhibitory activity compared to acarbose, as indicated by its low IC50 value of 850 µg/mL...Post-docking MM-GBSA study identified alpinumisoflavone and chlorogenic acid as exceptionally stable compounds. Molecular dynamics simulations conducted over 200 ns demonstrated that gallic acid and alpinumisoflavone produced the most stable complexes with caspase-3. These findings designate F. hispida fruits as a potential natural medicinal agent for Type 2 diabetes treatment, functioning through dual mechanisms of α-glucosidase inhibition and caspase-3 modulation of the apoptotic signaling pathway of the beta cells.

LC-MS/MS identified 18 polyphenolic compounds, with hyperoside (3.78 ± 0.05 µg/mL), protocatechuic acid (1.13 ± 0.06 µg/mL), chlorogenic acid (1.07 ± 0.06 µg/mL), and quercetin (0.53 ± 0.03 µg/mL) as the principal constituents...Furthermore, it demonstrated the highest skin permeation efficiency, with a quercetin diffusion coefficient of 35.12 × 10-5 cm2/min. These findings highlight the therapeutic potential of C. erythraea extract from aerial parts in topical formulations and underscore the enhancing role of Transcutol® P and Capryol® 90 in improving both the pharmacodynamic and pharmacokinetic properties of bioactive compounds.

HPLC analysis identified five phenolic acids, i.e., gallic acid, p-hydroxybenzoic acid (PHBA), chlorogenic acid, caffeic acid, and vanillic acid, and two flavonoids, i.e., catechin and hesperetin, with PHBA (163.66 mg/g of extract) being the most abundant. The 500 mg/kg dose demonstrated superior efficacy, comparable to the standard quercetin group. Histopathological examination revealed notable protection of cardiac tissue architecture in the high-dose PRCL-500 group; These findings suggest that PRCL rind extract contains potent compounds having antioxidant and cardioprotective properties and may be used as a natural therapeutic agent against cardiotoxicity.

CQAs also enhance plant stress tolerance to cold, arsenic, and pests by mechanisms such as scavenging reactive oxygen species and inhibiting pest mobility. While this review consolidates progress in the biosynthesis and bioactivity of CQAs specifically with caffeoyl substituents, future efforts should leverage modern biotechnological tools and interdisciplinary approaches to bridge critical knowledge gaps in their biosynthesis, transport, and clinical translation.

CGA and EGCG can regulate non-coding RNAs, including cancer-associated microRNAs. This review provides updated information on how CGA and EGCG exhibit anticancer activity via ROS-dependent anticancer pathways by regulating microRNA expression.

TQVYW inhibited lipopolysaccharide (LPS)-induced apoptosis and inflammation in RAW264.7 macrophages, synergistically enhancing anti-inflammatory effects of CA. This study reveals the molecular mechanism of natural peptide amplification of CA bioactivity and proposes an innovative strategy for the development of peptide-CA anti-inflammatory functional foods.

Perilla seed extract, Medicago flavonoids and Eucommia chlorogenic acid promoted lactation in canine mammary cells by participating in the "purine metabolism", "pyrimidine metabolism", "glycerophospholipid metabolism" and "biosynthesis of amino acids", and the three substances brought about anticancer and bacteriostatic effects. These findings could provide significant insight into the strategies of functional foods development in enhancing lactation function for human and pets.

Molecular docking revealed Rosmanol, Chlorogenic acid, and Carnosol as the most promising HSP90AA1 binders with strong predicted affinities. ADMET profiling confirmed their excellent drug-likeness and safety profiles, while molecular dynamics simulations validated the stability of the compound-protein complexes, further supporting their potential as HSP90 inhibitors. These findings suggest that rosemary-derived compounds may represent valuable candidates for anticancer drug development, though experimental validation is required to confirm their therapeutic efficacy.

UPLC-MS/MS was used to quantify the major phenolic compounds in DDP, including glycitin, procyanidin B2, vitexin, myricitrin, astilbin, chlorogenic acid, phlorizin, (-)-epicatechin, naringenin-7-O-glucoside, taxifolin-7-O-rhamnoside, rhoifolin, methylnissolin-3-O-glucoside, and scutellarein...Collectively, these findings suggest that SCFAs play a pivotal role in the anti-inflammatory effects of DDP by modulating the gut microbiota to enhance SCFA biosynthesis. These findings demonstrate that SCFAs serve as critical mediators of the anti-inflammatory properties of DDP, highlighting their considerable potential as natural therapeutic agents for intestinal inflammation.

This review, for the first time, provides a comparative analysis of six typical CGAs, systematically reviewing their specific distribution characteristics in traditional Chinese medicinal metabolites, biosynthetic pathways, biological targets, and pharmacological activities. This review provides a reference for the research and rational development and utilization of CGAs.

The components of CAE, including chlorogenic acid, kaempferol 3-O-rhamnoside, 1,3-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, and 4,5-dicaffeoylquinic acid, were identified...CAE alleviates dextran sulfate sodium-induced colitis by exerting anti-inflammatory and anti-apoptotic effects and maintaining intestinal barrier integrity. These findings support the potential of CAE as a natural multitarget therapeutic agent for UC.

This study uncovers a novel integrated mechanism whereby ZQFZ enhances PD-1 antibody efficacy via the gut microbiota-SCFAs-GPR109A axis, and NaB-mediated glycolysis inhibition under hypoxia further confirms its immunometabolic mechanism against CRC.