chlorogenic acid

Multiple drugs including chlorogenic acid (PubChem CID: 1794427), losartan (PubChem CID: 3961), and estrone sulfate (PubChem CID: 3001028), were found to potentially exhibit synergistic effects with theophylline. This finding provides a key scientific basis for repurposing the drug. Furthermore, a drug combination discovered through multiomics analysis and laboratory tests offers a direct and practical new path for developing new combination therapies for hepatocellular carcinoma in the clinic.

The primary mechanism involves the inhibition of the NF-κB pathway. This study provides a novel and efficient strategy for augmenting the bioactivities of natural products and highlights the considerable potential of chlorogenic acid-metal supramolecular assemblies as a promising new class of anti-inflammatory agents.

Increased levels of Gli3 repressor (Gli3-REP) and decreased GSK-3β phosphorylation further confirmed Hedgehog pathway inhibition. In conclusion, the current study provides the first evidence that CAN, CGA, and their combination modulate the Hedgehog pathway, suggesting their potential as novel therapeutic strategies for IPF.

Targeting these pathways with inhibitors, such as topotecan and chlorogenic acid, may provide novel treatment strategies. Furthermore, SUMOylation-driven alterations in transcription factors and DNA repair mechanisms contribute to therapy resistance. Understanding these mechanisms could pave the way for innovative interventions in glioblastoma management.

HPLC analysis revealed eight major phenolics, with gallic acid, chlorogenic acid, and daidzein being the predominant compounds...Molecular docking studies suggested that phenolic compounds effectively interact with the CDK4 active site, supporting their potential anticancer properties. These findings highlight B. aegyptiaca-derived SeNPs as promising candidates for biomedical applications.

Metabolomic characterization using UHPLC-ESI-QTOF-MS, supported by NMR, to confirm key compounds such as berberine, palmatine, chlorogenic acid, rutin, and borapetoside C. In vitro bioassays including: Antioxidant activity (e.g., radical-scavenging assay with EC50 determination)...Cultivation strategies that deliberately maintain or mimic beneficial stress conditions to preserve phytochemical richness. Broader geographical and genetic sampling to assess how generalizable the present chemotypic and bioactivity patterns are across the species.

Phenolic profiling by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) revealed a phenolic-acid-dominated signature, mainly hydroxycinnamic acids led by chlorogenic acid (691 µg/g), followed by caffeic acid (231 µg/g), p-coumaric acid (211 µg/g), and ferulic acid (50.4 µg/g), together with abundant hydroxybenzoic acids such as 3- and 4-hydroxybenzoic acids (188 and 183 µg/g, respectively)...In A549 lung carcinoma cells, viability decreased concentration-dependently; at the half-maximal inhibitory concentration (IC50), tumor necrosis factor-alpha (TNF-α) increased to 26.73 ng/mL, whereas transforming growth factor-beta (TGF-β) and interleukin-1 beta (IL-1β) decreased to 9.4 and 10.83 pg/mL, respectively, while at ½ × IC50 TNF-α was 1.3 ng/mL and TGF-β reached 46.6 pg/mL. Overall, this hydroxycinnamate- and hydroxybenzoate-rich aqueous extract exhibits moderate, target-selective antioxidant and enzyme-inhibitory activities together with dose-dependent immunomodulatory effects.

Chlorogenic acid acts as a promising multi-target ligand in CRC prevention, with our in silico evidence supporting its ability to modulate diverse oncogenic pathways. Further experimental studies are warranted to confirm its efficacy and translational potential.

BZD exerts anti-LC effects through multi-target regulation, particularly involving AKT1, PIK3CA, SRC, and HSP90AA1, as well as suppression of the PI3K-AKT signaling pathway. These findings provide a mechanistic basis for its potential clinical application in LC therapy and warrant further in vivo investigation.

The chemical composition of Moringa oleifera, including kaempferol, chlorogenic acid, quercetin, and niazimicin, varies between different biological parts of the plant (seeds, leaves, roots, and stems)...Studies indicate that Moringa oleifera can modulate the tumor microenvironment (TME) by reducing Treg polarization, enhancing NK cell cytotoxicity, and prompting the proliferation and clonal expansion of CD8+ and CD4+ T lymphocytes. Together, Moringa oleifera could be considered for the treatment of conditions related to immune dysregulation, such as cancer.

Notably, A. melanocarpa contains high levels of polyphenols such as cyanidin-3-galactoside, cyanidin-3-arabinoside, chlorogenic acid, quercetin, and epicatechin, as well as biologically active polysaccharides, including pectins and arabinogalactans...Recent studies show that supplementation with aronia products can improve inflammatory markers such as interleukin-6 and tumor necrosis factor alpha, highlighting its potential role in modulating the tumor microenvironment. Collectively, these findings position A. melanocarpa as a promising candidate for use in integrative strategies aimed at the prevention and adjunctive treatment of CRC.

Specifically, chlorogenic acid (ClA) was identified as the major component and primary agent responsible for the biological effects of HS-COF...Additionally, HS-COF exhibited a significant antioxidant activity, indicating its potential to combine a cytotoxic profile with a safety profile, thereby minimizing adverse effects on healthy cells. In conclusion, this study proposes HS-COF as a valuable adjuvant in CRC therapy, paving the way for its application in the pharmaceutical industry.