Cholangiocarcinoma

Lan C exhibits measurable but relatively low cardiotoxicity at concentrations effective against cholangiocarcinoma, with cardiac effects may be manageable at therapeutic doses. These findings support Lan C as a promising anti-tumor candidate with controllable cardiotoxicity under optimized dosing and clinical monitoring.

In conclusion, bile-derived exosomal miR-196a and miR-196b are novel BTC-specific biomarkers. MiR-196a may contribute to early BTC detection, enhance diagnostic accuracy in combination with serum markers, and assist in detecting metastasis.

P2, N=92, Not yet recruiting, Cancer Institute and Hospital, Chinese Academy of Medical Sciences

HIMT is rare and poses significant diagnostic challenges that often mimic other liver malignancies. This case report highlights the efficacy and safety of laparoscopic hepatectomy as both a diagnostic and therapeutic strategies.

Recognition and management of dermatologic adverse effects are critical to minimizing morbidity in the setting of life-prolonging oncologic treatments. Given the limitations of a single-case inference, further surveillance and study are needed to determine whether patients with pre-existing psoriasis may be at increased risk.

Quantitative cfDNA methylation monitoring using TMS is feasible and accurately reflects dynamic tumor burden in CCA. TMS may serve as a complementary adjunct to imaging and CA 19-9 for diagnosis, prognosis, and longitudinal disease monitoring, warranting validation in larger prospective studies.

In vitro experiments confirmed these findings. We observed that knocking down DLAT effectively suppressed both the migratory and proliferative potential of ICC cells.

Digital image analysis, radiomics, and machine learning are likely to improve quantification and may support future biomarker integration. A practical pathology-oriented approach should prioritize tissue stewardship, conservative interpretation of IHC results, and close coordination with molecular methods.

Our findings contribute to a more nuanced understanding of LEL-ICC pathogenesis and highlight the potential synergistic role of viral co-infections. Further case accumulation and mechanistic studies are needed.

In summary, based on multi-omics analysis, this study establishes a systemic mechanism that links tumor lipid metabolism, immune suppression, and therapeutic response in CCA. Targeting the USP1-mediated metabolic-immune axis not only significantly suppresses tumor progression but also enhances the efficacy of immunotherapy. These findings construct a conceptual framework that integrates metabolic reprogramming, immune evasion, and treatment sensitivity, thereby establishing USP1 as a precision therapeutic target with broad biological and clinical importance for patients with CCA.

In the MSKCC cohort, high tumor mutational burden (TMB-Hmed) correlated with poorer OS (HR = 1.43, P = 0.01), while PBRM1 mutations were associated with improved survival (HR = 0.50, P = 0.02). This study underscores the distinct genomic profiles of GBC and CCA, offering valuable insights into the molecular underpinnings of these aggressive cancers and supporting the development of precision medicine strategies.

P1/2, N=6, Not yet recruiting, Shanghai 6th People's Hospital