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    DRUG:

    CL-387785

    i
    Other names: WAY-EKI 785, CL-387785, EKI-785, CL 387785
    Company:
    Pfizer
    Drug class:
    EGFR inhibitor
    Related drugs:
    over2years
    Exosomes from PYCR1 knockdown bone marrow mesenchymal stem inhibits aerobic glycolysis and the growth of bladder cancer cells via regulation of the EGFR/PI3K/AKT pathway. (PubMed, Int J Oncol)
    Exo‑si‑PYCR1 blocked xenograft tumor growth and had good biocompatibility. Briefly, PYCR1 knocking loaded by BMSC‑derived Exos suppressed aerobic glycolysis and BC growth via the PI3K/AKT pathway by binding to EGFR.
    Journal
    |
    PRO-C3 (Pyrroline-5-carboxylate reductase)
    |
    CL-387785