P=N/A, N=5448, Recruiting, Peking University First Hospital

Although no current drugs directly target FCER1G, established agents such as aspirin may indirectly modulate its signaling. The present review aimed to summarize the current knowledge on the molecular structure, immune functions and regulatory mechanisms of FCER1G in inflammation and carcinogenesis, establishing a rationale for its potential use as a prognostic biomarker and therapeutic target.

The patient was treated with phlebotomy, low-dose aspirin, and hydroxyurea, alongside continued vitamin B12 replacement. Close follow-up after hematologic recovery is essential to avoid delayed diagnosis of coexisting hematologic malignancies and disorders. This case presents a combination of complex and extremely rare hematological scenarios, where various hematological disorders exert conflicting influences on red blood cell indices, making diagnosis challenging.

This study investigated the synergic chemopreventive potential of two non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA) and sulindac (SU), in combination with a pesco-vegetarian diet (PVD), using Apc-mutated PIRC rats, a well-established model of CRC. Notably, taxa such as Roseburia and Colidextribacter, previously linked to intestinal homeostasis and anti-inflammatory activity, were modulated by ASA and diet, suggesting a microbiome-mediated chemoprevention although mechanistic effect still need to be understood. These findings underscore the independent and complementary roles of diet and pharmacological interventions in CRC prevention and highlight the gut microbiota as a promising target for future personalised preventive strategies.

P4, N=177, Not yet recruiting, Western Galilee Hospital-Nahariya

P3, N=3208, Completed, Children's Hospital of Fudan University | Active, not recruiting --> Completed

P2, N=34, Active, not recruiting, Cumberland Pharmaceuticals | Trial completion date: May 2026 --> Aug 2026 | Trial primary completion date: Feb 2026 --> Jun 2026

P4, N=100, Not yet recruiting, Izmir Katip Celebi University

P3, N=890, Not yet recruiting, Curtin University

P1, N=30, Not yet recruiting, NYU Langone Health

No significant differences in TAS or TOS were observed between ELN (European LeukemiaNet) high-risk and low-risk patients, nor between those receiving hydroxyurea, aspirin, metformin, or ACE (angiotensin convertase enzyme) inhibitors and untreated patients (p > 0.05). Our findings demonstrate that oxidative stress is markedly elevated in patients with concomitant PV and MS, supporting a pathophysiological link between the two conditions. These results underscore the importance of considering oxidative stress in the clinical evaluation of PV patients with metabolic syndrome.

Mechanistic insights into ferroptosis highlight therapeutic vulnerabilities, especially in PIK3CA-mutant tumors, where aspirin and ferroptosis inducers show synergistic potential. Clinically, high-risk EOCRC patients often present with left-sided primary tumors, synchronous metastases, adverse histology, elevated CEA levels and a hereditary predisposition, with prognostic models incorporating these variables outperforming traditional staging. Collectively, accumulating evidence suggests that EOCRC liver metastases may represent a biologically and clinically distinct entity, although ongoing debates regarding the extent of this distinction underscore the need for age-specific molecular profiling and prospectively validated therapeutic strategies.