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    BIOMARKER:

    CXCL12 expression

    i
    Other names: CXCL12, C-X-C Motif Chemokine Ligand 12, Stromal Cell-Derived Factor 1, PBSF, Pre-B Cell Growth-Stimulating Factor, Chemokine (C-X-C Motif) Ligand 12, Intercrine Reduced In Hepatomas, SCYB12, TPAR1, SDF1, IRH, C-X-C Motif Chemokine 12, CXCL12, SDF-1a, SDF-1b, TLSF-A, TLSF-B, HSDF-1, SDF1A, SDF1B, SDF-1, TLSF, HIRH
    Entrez ID:
    6387
    Related biomarkers:
    Expression
    Mutation
    Others
    1year
    Key Genes Involved in the Beneficial Mechanism of Hyperbaric Oxygen for Glioblastoma and Predictive Indicators of Hyperbaric Oxygen Prolonging Survival in Glioblastoma Patients. (PubMed, Curr Med Sci)
    HBO is beneficial for glioblastoma. Glioblastoma patients with these predictive indicators may prolong survival with HBO therapy. These potential therapeutic targets especially COL1A1, ADAMTS1 and PTBP3 deserve further validation.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    NF1 (Neurofibromin 1) • MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • PD-1 (Programmed cell death 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • MDM4 (The mouse double minute 4) • CDK6 (Cyclin-dependent kinase 6) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • CA9 (Carbonic anhydrase 9) • COL1A1 (Collagen Type I Alpha 1 Chain) • MMP9 (Matrix metallopeptidase 9) • PCNA (Proliferating cell nuclear antigen) • ADAMTS1 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1) • CDC42 (Cell Division Cycle 42) • CDKN1B (Cyclin dependent kinase inhibitor 1B) • CXCR5 (C-X-C Motif Chemokine Receptor 5) • DDIT3 (DNA-damage-inducible transcript 3) • IGFBP3 (Insulin-like growth factor binding protein 3) • IGFBP5 (Insulin Like Growth Factor Binding Protein 5) • BAK1 (BCL2 Antagonist/Killer 1) • CDC25A (Cell Division Cycle 25A) • COL12A1 (Collagen Type XII Alpha 1 Chain) • COL8A1 (Collagen Type VIII Alpha 1 Chain) • EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MCM2 (Minichromosome maintenance complex component 2) • RHOJ (Ras Homolog Family Member J) • NLRP2 (NLR Family Pyrin Domain Containing 2)
    |
    TP53 expression • CXCL12 expression • CDK6 expression • CDKN1B expression • PCNA expression
    1year
    The Effect of C-X-C Motif Chemokine Ligand 12 in Colorectal Cancer Associated with Chemoresistance and Radioresistance as Well as Stemness. (PubMed, Iran J Public Health)
    In addition, the chemosensitivity and radiotherapy tolerance were elevated after transfected with CXCL12. CXCL12 could be a potential promote biomarkers in CRC and also promote the chemosensitivity and radiotherapy tolerance.
    Journal
    |
    CXCL12 (C-X-C Motif Chemokine Ligand 12)
    |
    CXCL12 expression
    1year
    Integrative multi-omics analysis reveals the role of tumor-associated endothelial cells and their signature in prognosis of intrahepatic cholangiocarcinoma. (PubMed, J Transl Med)
    The TEC score is a promising and reliable biomarker for predicting genetic mutations and prognosis in ICC patients. Enhancing the regulation of the CXCL12/CXCR4 signaling pathway may represent a potential novel therapeutic target for ICC treatment.
    Journal • IO biomarker
    |
    KRAS (KRAS proto-oncogene GTPase) • CD8 (cluster of differentiation 8) • BAP1 (BRCA1 Associated Protein 1) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CD4 (CD4 Molecule)
    |
    KRAS mutation • BAP1 mutation • CXCL12 expression • CXCL12 overexpression
    1year
    HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer. (PubMed, bioRxiv)
    CXCL9 + macrophages and dendritic cells and CXCL12-expressing stromal cells likely recruit CXCR3/CXCR4-expressing NK and T cells and CXCR7 + HLA-E HIGH tumor cells. NK and CD8 T cells remain functional within BCG-unresponsive tumors but are inhibited by HLA-E and PD-L1, providing a framework for combined NKG2A and PD-L1 blockade strategy for bladder-sparing treatment of BCG-unresponsive NMIBC.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • IFNG (Interferon, gamma) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • HLA-E (Major Histocompatibility Complex, Class I, E) • CXCR3 (C-X-C Motif Chemokine Receptor 3) • ACKR3 (Atypical Chemokine Receptor 3) • KLRC1 (Killer Cell Lectin Like Receptor C1)
    |
    PD-L1 expression • IFNG expression • CXCL12 expression • CXCR4 expression
    1year
    Concise review: breast cancer stems cells and their role in metastases. (PubMed, Ann Med Surg (Lond))
    Aberrantly expressed vascular cell adhesion molecule-1 (VCAM-1) that binds to collagen and elastin fibers on pulmonary parenchyma, and CXCR4 of BCSCs and CXCL12 in lung microenvironment may promote the cells homing and metastasis to lung. As in various types of BC metastases different markers that expressed by the cells and target organ microenvironment are responsible, BCSCs immunophenotyping can be used as target markers to predict the disease prognosis and treatment.
    Review • Journal
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4) • CD44 (CD44 Molecule) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • CD24 (CD24 Molecule) • ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • NES (Nestin) • VCAM1 (Vascular Cell Adhesion Molecule 1) • PROM1 (Prominin 1)
    |
    CD44 expression • CXCL12 expression
    over1year
    Establishment of Early Blood Perfusion Promotes CXCL12 Expression and Recruits Monocytes/Macrophages in Damaged Adipose Tissue in Mice Model. (PubMed, Aesthetic Plast Surg)
    Established blood perfusion leads to up-regulation of CXCL12 during adipose tissue repair and regeneration, which may increase recruitment of monocytes to damaged adipose tissue. These findings increase understanding of the cellular events involved in fat graft survival after grafting.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • MRC1 (Mannose Receptor C-Type 1) • PLIN2 (Perilipin)
    |
    CXCL12 expression
    over1year
    Tertiary lymphoid structures as a potential prognostic biomarker for combined hepatocellular-cholangiocarcinoma. (PubMed, Hepatol Int)
    The spatial distribution and density of TLSs revealing the characteristics of the cHCC-CCA immune microenvironment, significantly correlated with prognosis and provided a potential immunotherapy response biomarker for cHCC-CCA.
    Journal • IO biomarker
    |
    CD8 (cluster of differentiation 8) • CXCL12 (C-X-C Motif Chemokine Ligand 12)
    |
    CXCL12 expression
    over1year
    The effect of CXCL12 on survival outcomes of patients with viral hepatitis-associated hepatocellular carcinoma after hepatectomy. (PubMed, Heliyon)
    Our findings suggest that, when assessing the prognostic significance of CXCL12 in HCC, it is essential to consider the expression level of its receptor. Nevertheless, CXCL12 can potentially serve as a promising prognostic marker for HCC.
    Journal
    |
    CXCL12 (C-X-C Motif Chemokine Ligand 12) • ACKR3 (Atypical Chemokine Receptor 3)
    |
    CXCL12 expression • CXCL12-L • CXCR4 expression
    over1year
    Ethanolic extract of Euphorbia royleana Boiss. reduces metastasis of breast cancer cells and inhibits tumor progression in vivo. (PubMed, Med Oncol)
    Moreover, the GC-MS data revealed the presence of biologically active compounds (Lupeol, Phytol, phytosterol) and some rare (9, 19-Cyclolanost) phyto metabolites in ERA extract. However, further studies are suggestive to identify and isolate the therapeutic agents from ERA to combat BC and metastasis.
    Preclinical • Journal
    |
    CDH1 (Cadherin 1) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • MMP2 (Matrix metallopeptidase 2) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • CXCL1 (Chemokine (C-X-C motif) ligand 1)
    |
    CDH1 expression • CXCL12 expression
    over1year
    Inducible CXCL12/CXCR4-dependent extramedullary hematopoietic niches in the adrenal gland. (PubMed, Blood)
    Mirroring our findings in mice, we found reticular CXCL12+ cells co-expressing master niche-regulator FOXC1 in primary samples from human adrenal myelolipomas, a benign tumor composed of adipose and hematopoietic tissue. Our findings reignite long-standing questions regarding hormonal regulation of hematopoiesis and provide a novel model to facilitate the study of adult-specific inducible hematopoietic niches which may pave the way to therapeutic applications.
    Journal
    |
    PDGFRA (Platelet Derived Growth Factor Receptor Alpha) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • FOXC1 (Forkhead Box C1)
    |
    CXCL12 expression
    over1year
    In vitro effects and mathematical modelling of CTCE-9908 (a chemokine receptor 4 antagonist) on melanoma cell survival. (PubMed, Clin Exp Pharmacol Physiol)
    CTCE-9908 significantly inhibited melanoma cell survival at a concentration 10 times lower than the IC50 in B16 F10 cells but not RAW 264.7 cells. However, CTCE-9908 did not affect CXCR4 phosphorylation, apoptosis, or cell cycle distribution in either cell line.
    Preclinical • Journal
    |
    CXCL12 (C-X-C Motif Chemokine Ligand 12) • CASP3 (Caspase 3)
    |
    CXCL12 expression
    |
    PTX-9908
    over1year
    The CXCR4 might be a potential biomarker for esophageal squamous cell carcinoma: A meta-analysis. (PubMed, Medicine (Baltimore))
    CXCR4 might be a potential biomarker for the progress and prognosis evaluation, and therapeutic target for ESCC.
    Retrospective data • Journal
    |
    CXCR4 (Chemokine (C-X-C motif) receptor 4) • CXCL12 (C-X-C Motif Chemokine Ligand 12)
    |
    CXCL12 expression • CXCR4 expression