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    BIOMARKER:

    CYP17A1 expression

    i
    Other names: Cytochrome P450 Family 17 Subfamily A Member 1, Steroid 17-Alpha-Monooxygenase, Cytochrome P450 Subfamily XVII (Steroid 17-Alpha-Hydroxylase), Adrenal Hyperplasia, Cytochrome P450 Family 17 Subfamily A Polypeptide 1, Steroid 17-Alpha-Hydroxylase/17 20 Lyase, 17-Alpha-Hydroxyprogesterone Aldolase, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, CYPXVII, CYP17, S17AH, Cytochrome P450 XVIIA1, P450C17, CPT7, CYP17A1
    Entrez ID:
    1586
    Related biomarkers:
    Expression
    Mutation
    1year
    Immunohistochemical expression of CYP11A1, CYP11B, CYP17, and HSD3B2 in functional and nonfunctional canine adrenocortical tumors. (PubMed, J Vet Intern Med)
    Our findings suggest it is not possible to determine functionality of canine ACT by immunohistochemistry for steroidogenic enzymes. Tumor size cannot be used to infer functionality of adrenal tumors.
    Journal
    |
    CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • CYP11B1 (Cytochrome P450 Family 11 Subfamily B Member 1)
    |
    CYP17A1 expression
    1year
    Amino polycarboxylic acids-modified abiraterone derivatives as potential injectable anti-prostate cancer agents. (PubMed, Bioorg Chem)
    Abi-DTPA was the main form in the plasma and exhibited lower toxicity after intravenous administration. These findings suggest that Abi-DTPA can be used as a novel injectable anti-prostate cancer agent.
    Journal • PARP Biomarker
    |
    CASP3 (Caspase 3) • CASP9 (Caspase 9)
    |
    CYP17A1 expression
    |
    abiraterone acetate
    over1year
    Exploring the Molecular Mechanisms of Huaier on Modulating Metabolic Reprogramming of Hepatocellular Carcinoma: A Study based on Network Pharmacology, Molecular Docking and Bioinformatics. (PubMed, Curr Pharm Des)
    This study provided a workflow for understanding the mechanism of Huaier in regulating the metabolic reprogramming of HCC.
    Journal
    |
    AKR1C3 (Aldo-Keto Reductase Family 1 Member C3) • CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide 2) • CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4) • CYP1A1 (Cytochrome P450 Family 1 Subfamily A Member 1)
    |
    CYP17A1 expression
    over1year
    Protective Effect of Petroselinum Crispum Methanolic Extract against Acrylamide-induced Reproductive Toxicity in Male Rats through NF-ĸB, Kinesin, steroidogenesis Pathways. (PubMed, Reprod Toxicol)
    P. crispum showed protective effects against acrylamide-induced reproductive toxicity by suppressing oxidative damage and inflammatory pathways.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • RELA (RELA Proto-Oncogene)
    |
    CYP17A1 expression • IL6 expression
    over1year
    Cytochrome P450 genes expression in human prostate cancer. (PubMed, Mol Genet Metab Rep)
    Therefore, the expression of CYPs is not directly associated with prostate cancer but is largely determined by genetic, epigenetic factors, as well as endogenous substrates and xenobiotics. The significant correlative relationship between CYPs and genes associated with cancer may indicate common regulatory pathways that may have a synergistic effect on the tumor, ensuring the survival of cancer cells.
    Journal
    |
    ACTA2 (Actin Alpha 2 Smooth Muscle) • CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • IRF1 (Interferon Regulatory Factor 1) • CDH2 (Cadherin 2) • MMP9 (Matrix metallopeptidase 9) • CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • CYP27A1 (Cytochrome P450 Family 27 Subfamily A Member 1) • CYP2R1 (Cytochrome P450 Family 2 Subfamily R Member 1) • VDR (Vitamin D Receptor)
    |
    IRF1 expression • CYP17A1 expression • CYP4B1 expression
    over1year
    New insights into the all-testis differentiation in zebrafish with compromised endogenous androgen and estrogen synthesis. (PubMed, PLoS Genet)
    The interaction between Fancl and Tp53 was observed via the WD repeat domain (WDR) and C-terminal domain (CTD) of Fancl and the DNA binding domain (DBD) of Tp53, leading to the K48-linked polyubiquitination degradation of Tp53 activated by the ubiquitin ligase, Fancl. Our results show that testis fate in cyp17a1-/- fish is determined by Dmrt1, which is thought to stabilize Tp53 by inhibiting fancl transcription during the critical stage of sexual fate determination in zebrafish.
    Journal
    |
    TP53 (Tumor protein P53) • CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • FANCL (FA Complementation Group L) • DMRT1 (Doublesex And Mab-3 Related Transcription Factor 1)
    |
    CYP17A1 expression
    almost2years
    Dual inhibition of CYP17A1 and HDAC6 by abiraterone-installed hydroxamic acid overcomes temozolomide resistance in glioblastoma through inducing DNA damage and oxidative stress. (PubMed, Cancer Lett)
    In vivo studies revealed that compound 12 effectively suppressed tumor growth in xenograft and orthotopic mouse models without inducing significant adverse effects. These findings highlight the potential of dual CYP17A1 and HDAC6 inhibition as a promising strategy for overcoming treatment resistance in GBM and offer new hope for improved therapeutic outcomes.
    Journal
    |
    HDAC6 (Histone Deacetylase 6)
    |
    CYP17A1 expression • HDAC6 expression
    |
    temozolomide • abiraterone acetate
    almost2years
    Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites. (PubMed, J Steroid Biochem Mol Biol)
    Precursor steroids upstream of DHEA were converted down the first steps of the alternative DHT biosynthesis pathway, but did not proceed through to active androgen generation. Comprehensive steroid flux analysis of (CR)PC cells provides strong evidence against intratumoral de novo androgen biosynthesis and demonstrates that androgen precursor steroids downstream of CYP17A1 activities constitute the major source of intracrine androgen generation.
    Journal
    |
    AR (Androgen receptor) • CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1)
    |
    CYP17A1 expression
    2years
    Protective effect of Huangqi-Guizhi-Wuwutang against cyclophosphamide-induced spermatogenesis dysfunction in mice by promoting steroid hormone biosynthesis. (PubMed, J Ethnopharmacol)
    Our data has demonstrated the effectiveness of HGW in improving CTX-induced spermatogenic dysfunction by enhancing hormonal steroid synthesis in a model system, indicating the potential chemoprotective effects of HGW against CTX-induced spermatotoxicity.
    Preclinical • Journal
    |
    CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1)
    |
    CYP17A1 expression
    |
    cyclophosphamide
    over2years
    Selectivity of Osilodrostat as an Inhibitor of Human Steroidogenic Cytochromes P450. (PubMed, J Steroid Biochem Mol Biol)
    Our binding experiments confirm the high affinity of LCI699 to CYP11B1 and CYP11B2 (K ≈ 1nM or less) and much weaker binding for CYP11A1 (K = 18.8 μM). Our results confirm the selectivity of LCI699 for CYP11B1 and CYP11B2 and demonstrate partial inhibition of CYP11A1 but not CYP17A1 and CYP21A2.
    Journal
    |
    CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • CYP1A2 (Cytochrome P450, family 1, subfamily A, polypeptide 2)
    |
    CYP17A1 expression
    over2years
    Disruption of neurosteroid synthesis and release by tris(2,3-dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro. (PubMed, J Appl Toxicol)
    Finally, our studies have demonstrated an increase in the expression of Cyp19a1 mRNA, an enzyme metabolizing T to E , with a simultaneous increase in the amount of E in cells. Our data clearly show that TBC in an in vitro environment acts as EDCs, which may lead to serious consequences for the proper development and functioning of the brain.
    Preclinical • Journal
    |
    CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1)
    |
    CYP17A1 expression
    over2years
    A new prognostic model for RHOV, ABCC2, and CYP4B1 to predict the prognosis and association with immune infiltration of lung adenocarcinoma. (PubMed, J Thorac Dis)
    Lymph node metastasis-related genes RHOV, ABCC2, and CYP4B1 are associated with a poor prognosis in LUAD. A prognostic model based on RHOV, ABCC2, and CYP4B1 might predict the prognosis of LUAD patients and be associated with immune infiltration.
    Journal
    |
    ABCC2 (ATP Binding Cassette Subfamily C Member 2) • CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) • CYP4B1 (Cytochrome P450 Family 4 Subfamily B Member 1) • KRT16 (Keratin 16) • STC1 (Stanniocalcin 1)
    |
    CYP17A1 expression