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    DRUG:

    dacarbazine

    Company:
    Generic mfg.
    Drug class:
    DNA synthesis inhibitor
    Related drugs:
    7d
    Brentuximab Vedotin Combined With AVD Chemotherapy in Patients With Newly Diagnosed Early Stage, Unfavorable Risk Hodgkin Lymphoma (clinicaltrials.gov)
    P=N/A, N=118, Completed, Memorial Sloan Kettering Cancer Center | Active, not recruiting --> Completed | Trial completion date: May 2027 --> Jun 2026 | Trial primary completion date: May 2027 --> Jun 2026
    Trial completion • Trial completion date • Trial primary completion date
    |
    TNFRSF8 (TNF Receptor Superfamily Member 8)
    |
    TNFRSF8 positive
    |
    doxorubicin hydrochloride • Adcetris (brentuximab vedotin) • dacarbazine • vinblastine
    8d
    Brentuximab Vedotin Combined With AVD Chemotherapy in Patients With Newly Diagnosed Early Stage, Unfavorable Risk Hodgkin Lymphoma (clinicaltrials.gov)
    P=N/A, N=118, Active, not recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: May 2026 --> May 2027 | Trial primary completion date: May 2026 --> May 2027
    Trial completion date • Trial primary completion date
    |
    TNFRSF8 (TNF Receptor Superfamily Member 8)
    |
    TNFRSF8 positive
    |
    doxorubicin hydrochloride • Adcetris (brentuximab vedotin) • dacarbazine • vinblastine
    10d
    PLRG-HL05: Efficacy and Tolerability of N-AVD compared to BrECADD in patients with advanced Hodgkin Lymphoma (N-BRAVE) (2026-525263-41-00)
    P2/3, N=370, Not yet recruiting, Polska Grupa Badawcza Chloniakow
    New P2/3 trial
    |
    TNFRSF8 (TNF Receptor Superfamily Member 8)
    |
    TNFRSF8 positive
    |
    Opdivo (nivolumab) • doxorubicin hydrochloride • etoposide IV • Adcetris (brentuximab vedotin) • dacarbazine • vinblastine
    14d
    Zerumbone Induces Apoptosis and Inhibits Migration of A2058 Melanoma stem-like Cells by Producing Reactive Oxygen Species, Causing G2/M Cell Cycle Arrest, and Controlling the Expression of Genes Linked to Metastasis. (PubMed, Indian J Clin Biochem)
    Thus, Zerumbone has potential as a practical approach to battle melanoma, either as a standalone treatment or in conjunction with Dacarbazine. However, more pre-clinical and clinical studies are required to investigate its efficacy.
    Journal • IO biomarker
    |
    TP53 (Tumor protein P53) • BCL2 (B-cell CLL/lymphoma 2) • MMP2 (Matrix metallopeptidase 2) • MITF (Melanocyte Inducing Transcription Factor)
    |
    dacarbazine
    15d
    A Phase I, Open-Label, Multi-center Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD6244 (ARRY-142886) (clinicaltrials.gov)
    P1, N=140, Completed, AstraZeneca | Active, not recruiting --> Completed
    Trial completion
    |
    erlotinib • docetaxel • Koselugo (selumetinib) • temsirolimus • dacarbazine
    19d
    Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma (clinicaltrials.gov)
    P2, N=49, Completed, Northwestern University | Unknown status --> Completed
    Trial completion
    |
    Adcetris (brentuximab vedotin) • dacarbazine • vinblastine
    21d
    Five-Year Survival with Tebentafusp in Metastatic Uveal Melanoma. (PubMed, Ann Oncol)
    In the longest survival follow-up of a randomized trial in metastatic uveal melanoma, tebentafusp continues to provide long-term survival benefit in previously untreated HLA-A*02:01-positive patients.
    Journal
    |
    HLA-A (Major Histocompatibility Complex, Class I, A)
    |
    HLA-A*02:01
    |
    Keytruda (pembrolizumab) • Yervoy (ipilimumab) • dacarbazine • Kimmtrak (tebentafusp-tebn)
    24d
    Rapidly progressive Hodgkin lymphoma causing superior vena cava syndrome in late pregnancy: a case report and literature review. (PubMed, Front Med (Lausanne))
    Postpartum positron emission tomography/computed tomography demonstrated extensive supradiaphragmatic disease, and chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine was promptly initiated. The patient showed a favorable clinical and metabolic response, and the neonate demonstrated normal early postnatal development. This case highlights the importance of early recognition and multidisciplinary management of superior vena cava syndrome in pregnancy and raises the hypothesis that pregnancy-associated immunologic changes, including interleukin-6-mediated pathways, may contribute to accelerated disease progression.
    Journal
    |
    IL6 (Interleukin 6)
    |
    doxorubicin hydrochloride • dacarbazine • bleomycin • vinblastine
    27d
    Fitness-adapted, Pembrolizumab-based Therapy for Untreated Classical Hodgkin Lymphoma Patients 60 Years of Age and Above (clinicaltrials.gov)
    P2, N=24, Active, not recruiting, University of Virginia | Recruiting --> Active, not recruiting | N=44 --> 24
    Enrollment closed • Enrollment change
    |
    Keytruda (pembrolizumab) • doxorubicin hydrochloride • Adcetris (brentuximab vedotin) • dacarbazine • vinblastine
    1m
    Plexin A2 Knockdown Enhances Apoptosis in Chemotherapy Treated Melanoma Cells. (PubMed, Oncol Res)
    This study elucidates alterations in adhesion molecule expression in melanoma cells acquiring resistance to dacarbazine (DTIC) and entering the G0 state...These findings suggest that PLXNA2 down-regulation in DTIC-treated cancer cells promotes their apoptosis. Therefore, targeting focal adhesion molecules during chemotherapy can increase the sensitivity of tumor cells to anticancer treatment.
    Journal
    |
    FGFR2 (Fibroblast growth factor receptor 2) • PIK3R1 (Phosphoinositide-3-Kinase Regulatory Subunit 1)
    |
    dacarbazine
    1m
    Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667) (clinicaltrials.gov)
    P2, N=340, Active, not recruiting, Merck Sharp & Dohme LLC | N=243 --> 340
    Enrollment change
    |
    Keytruda (pembrolizumab) • doxorubicin hydrochloride • cyclophosphamide • etoposide IV • vincristine • prednisone • dacarbazine • bleomycin • vinblastine
    1m
    SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma (clinicaltrials.gov)
    P3, N=360, Recruiting, Immatics US, Inc. | N=108 --> 360
    Enrollment change
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation
    |
    Keytruda (pembrolizumab) • Yervoy (ipilimumab) • carboplatin • temozolomide • albumin-bound paclitaxel • cyclophosphamide • dacarbazine • Amtagvi (lifileucel) • relatlimab (BMS-986016) • anzutresgene autoleucel (IMA203)