dactinomycin

She was managed according to the Chinese Children Cancer Group (CCCG)-WT-2019 protocol, receiving neoadjuvant VAD (vincristine, actinomycin D, and doxorubicin) chemotherapy, followed by staged bilateral nephron-sparing surgery. This highlights the limitations of current histology- and stage-based approaches for specific molecular subtypes. Current evidence supports more aggressive surgical intervention for high-risk cases, but it is essential to balance the need for renal function preservation with the goal of achieving oncological control.

Our study demonstrates that ALKBH5 promotes cisplatin resistance in OSCC through m6A-dependent demethylation of FOXA1 transcripts, highlighting the ALKBH5-FOXA1 axis as a promising therapeutic target for overcoming this resistance.

The present study aimed to investigate the functional role and molecular mechanisms of long intergenic non‑protein coding RNA 1117 (LINC01117) in lung adenocarcinoma (LUAD)...Actinomycin D was used to inhibit RNA transcription...In conclusion, LINC01117 may serve as a notable prognostic biomarker that promotes cell proliferation in LUAD. HOXD8 may function as a downstream target of LINC01117, with LINC01117 exerting its pro‑proliferative effects by increasing HOXD8 mRNA stability.

METTL3 may drive DE-DLBCL cell cycle progression and RTX resistance by activating MYC and BCL2 transcription via YTHDF2-mediated m6A modification of β-catenin, revealing a novel mechanism of indirect transcriptional regulation in lymphoma and a potential therapeutic target.

TRIM71 may function as a tumor suppressor in CC by regulating Nectin4 expression and influencing Wnt/β-catenin signaling, EMT, tumor progression, and angiogenesis.

The m5C modification level and stability of Snail mRNA were determined by MeRIP and actinomycin D assays...In vivo, AGR2 overexpression promoted tumor growth and EMT through neutrophil-dependent activation of the ALYREF-Snail axis. TAN-secreted AGR2 enhances ALYREF stability, thereby promoting m5C-dependent Snail mRNA stabilization and sustaining EMT and CRC progression.

P3, N=249, Completed, Children's Oncology Group | Active, not recruiting --> Completed

P3, N=395, Completed, Children's Oncology Group | Trial completion date: Nov 2026 --> Mar 2026 | Active, not recruiting --> Completed

RUNX1 alters m⁵C methylation levels by regulating NSUN2 transcription to promote FABP5-mediated lipid metabolic reprogramming, which in turn enhances PD-L1 expression and consequently induces immune resistance in NSCLC.

P3, N=808, Completed, Children's Oncology Group | Active, not recruiting --> Completed

RBFOX2 interacts with FUBP1, destabilizes its mRNA, and promotes ferroptosis, thereby inhibiting CRC proliferation and metastasis, whereas FUBP1 exerts oncogenic effects. These findings provide novel insights into CRC molecular mechanisms and establish a theoretical foundation for targeted therapeutic strategies.

Three cycles of VAC (vincristine + actinomycin D + cyclophosphamide) combination chemotherapy and another cervical conization surgery were taken out for maximum therapeutic effect. This rare case reminds us that the tumor diagnosis should always be taken into consideration for any unexpected mass. A multi-disciplinary team including gynecologist, pediatrician, oncologist, radiologist, and pathologist could be a good choice to avoid such a pitfall of misdiagnosis.