Patients underwent 135 sessions using either HepaSphere beads plus HAIC-FOLFOX (HEPA-HAIC, n = 33) or DC bead plus HAIC-FOLFOX (DCB-HAIC, n = 29)...Nausea, vomiting, and severe pain were significantly less frequent with HEPA-HAIC (5.6% vs 31.7%, p = 0.001; 4.2% vs 31.7%, p < 0.001; 8.3% vs 22.2%, p = 0.01). DEB-TACE plus HAIC was feasible and demonstrated intrahepatic disease control with acceptable tolerability in unresectable GCLM; HEPA-HAIC showed a favorable safety profile.

3 days ago

Journal

CEACAM5 (CEA Cell Adhesion Molecule 5)

5-fluorouracil • leucovorin calcium • DC Bead (E7040)

almost6years

[VIRTUAL] Radiological Response Predict Tumor Recurrence in Patients Treated With TACE Before Liver Transplantation. (GEST 2020)

Material and We retrospectively evaluated the preoperative predictors of HCC recurrence in 70 patients treated with conventional (n = 16) or doxorubicin-eluting bead TACE (n = 54) before LT. The radiological response and inflammatory markers are predictive of tumour recurrence and allow the proper selection of TACE-treated candidates for LT.

almost 6 years ago

Clinical

AFP (Alpha-fetoprotein)

doxorubicin hydrochloride • DC Bead (E7040)

6years

[VIRTUAL] Safety, tolerability, and efficacy of transarterial chemoembolization using anthracyclines-loaded drug-eluting microspheres for treatment of patients with unresectable hepatocellular carcinoma: Pooled analyses (ESMO-GI 2020)

Conclusion The treatment of patients with unresectable HCC with TACE using LifePearl® loaded with doxorubicin or idarubicin showed good tolerance with acceptable toxicity and high tumor response rate that translated into promising PFS, TTUP and OS. Legal entity responsible for the study The authors. Funding Has not received any funding.

6 years ago

Clinical

AFP (Alpha-fetoprotein)

doxorubicin hydrochloride • idarubicin hydrochloride • DC Bead (E7040)