dexamethasone

P4, N=42, Completed, Emory University | Recruiting --> Completed

P2, N=0, Withdrawn, UNC Lineberger Comprehensive Cancer Center | N=39 --> 0 | Suspended --> Withdrawn

P=N/A, N=100, Not yet recruiting, PETHEMA Foundation

P3, N=28, Completed, Immune Oncology Research Institute | Recruiting --> Completed | N=40 --> 28

P1, N=165, Recruiting, K36 Therapeutics, Inc. | N=125 --> 165

P2/3, N=345, Active, not recruiting, Pharma Mar S.A. | Recruiting --> Active, not recruiting

These results indicate that BoNT/A effectively alleviates inflammatory and vascular responses in a rosacea mouse model, highlighting its potential as a promising preventive approach for rosacea.

P2/3, N=340, Recruiting, Merck Sharp & Dohme LLC | Trial completion date: Oct 2029 --> Oct 2033 | Trial primary completion date: Feb 2029 --> Oct 2033

This case highlights the diagnostic challenge of primary gastrointestinal ENKL in patients presenting with abdominal pain and hematochezia in the absence of computed tomography (CT) abnormalities. Persistent unexplained abdominal pain should prompt consideration of rare ulcerative small bowel diseases, including ENKL, particularly when perforation is a potential complication. Early multidisciplinary intervention is essential to improve the outcomes of this devastating condition.

P3, N=720, Not yet recruiting, Dana-Farber Cancer Institute

Lung mesenchymal stem cells (MSCs; platelet-derived growth factor receptor α+ CD31- CD45- CD326- cells) were isolated and differentiated into myofibroblasts by culturing them with 15% fetal bovine serum (FBS) for 6 d. In asthmatic lungs, α-SMA+ myofibroblasts showed increased Bcl-xL expression, which was unaffected by dexamethasone (DEX) treatment. However, co-treatment with the Bcl-xL inhibitor navitoclax significantly restored steroid sensitivity...These findings indicate that Bcl-xL-expressing myofibroblasts contribute to the development of glucocorticoid resistance in fibrotic lungs in severe asthma. Targeting Bcl-xL may provide a novel therapeutic strategy to restore steroid responsiveness in severe asthma.

Renal SEM imaging revealed severe podocyte surface deterioration and structural damage to tubules in the OA, OA + TCZ-2 and OA + DEX-10 groups. Tocilizumab treatment at a dose of 4 mg/kg appeared to be more effective in certain evaluated parameters compared to other treatments in improving renal glomerular and tubular damage, expression levels of proinflammatory cytokines (TNF-α and IL-33), and antioxidant parameters in cases of oleic acid-induced ARDS.