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BIOMARKER:
EGFR exon 19 deletion
i
Other names:
EGFR, ERBB, ERBB1, Epidermal growth factor receptor
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News alerts, weekly reports and conference planners
Entrez ID:
1956
Related biomarkers:
Expression
Mutation
CNA
Fusion
Others
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›
Related tests:
FoundationOne® CDx (110)
Guardant360® CDx (54)
FoundationOne® Liquid CDx (21)
cobas® EGFR Mutation Test v2 (13)
Oncomine™ Dx Target Test (11)
therascreen® EGFR RGQ PCR Kit (5)
MI Cancer Seek™
OncoReveal™ Dx Lung and Colon Cancer Assay (O/RDx-LCCA)
Target Selector™ EGFR Mutation Assay
FoundationOne® CDx (110)
Guardant360® CDx (54)
FoundationOne® Liquid CDx (21)
cobas® EGFR Mutation Test v2 (13)
Oncomine™ Dx Target Test (11)
therascreen® EGFR RGQ PCR Kit (5)
MI Cancer Seek™
OncoReveal™ Dx Lung and Colon Cancer Assay (O/RDx-LCCA)
Target Selector™ EGFR Mutation Assay
Associations
(79)
News
Trials
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Latest
1d
TROP-LUNG: A Phase II Study of Sacituzumab Tirumotecan in Combination With Furmonertinib in Patients With Non-squamous Non-Small Cell Lung Cancer Who Have Progressed After EGFR-TKI and Platinum-Based Chemotherapy (clinicaltrials.gov)
P2, N=25, Recruiting, Tianjin Medical University Cancer Institute and Hospital
1 day ago
New P2 trial
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Ivesa (firmonertinib) • Jiataile (sacituzumab tirumotecan)
2d
A Prospective, Non-interventional, Real-World Study on Patient-Reported Outcomes of Third-Generation EGFR-TKIs Combined with Radiotherapy for Advanced NSCLC Patients with EGFR Mutations (ChiCTR2600121548)
P=N/A, N=100, West China Hospital of Sichuan University; West China Hospital of Sichuan University
2 days ago
New trial • Real-world evidence
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
2d
Zorifertinib Plus Radiotherapy as First-Line Treatment in EGFR-Mutant NSCLC with Brain Metastases: A Prospective Clinical Study (ChiCTR2600121513)
P4, N=38, Recruiting, Chongqing University Cancer Hospital; Chongqing University Cancer Hospital
2 days ago
New P4 trial
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Zorifer (zorifertinib)
2d
Aumolertinib with or without Radiotherapy for Treatment-Naïve EGFR-Mutated Oligometastatic Non-Small Cell Lung Cancer: A Phase III, Multicenter, Open-Label, Randomized Controlled Trial (ChiCTR2600121546)
P3, N=172, West China Hospital of Sichuan University; West China Hospital of Sichuan University
2 days ago
New P3 trial
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Ameile (aumolertinib)
2d
Almonertinib Plus Oral Vinorelbine as First-line Treatment for EGFR-sensitive Mutation-positive Advanced Non-small Cell Lung Cancer with Performance Status 2-4: A Prospective, Multicenter, Single-arm, Phase II Clinical Study (ChiCTR2600121540)
P2, N=62, West China Hospital of Sichuan University; West China Hospital of Sichuan University
2 days ago
New P2 trial
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Ameile (aumolertinib) • Navelbine oral (vinorelbine tartrate oral)
2d
A Real-World Study Evaluating the Efficacy and Safety of Zorifertinib in Patients with NSCLC and Leptomeningeal Metastases after Resistance to Third-Generation EGFR-TKIs: A Bidirectional, Non-Interventional, Observational, Multicenter Study (ChiCTR2600121192)
P=N/A, N=120, Nanjing Brain Hospital; Nanjing Brain Hospital
2 days ago
New trial • Real-world evidence
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Zorifer (zorifertinib)
2d
ctDNA-guided dynamic monitoring for befotertinib combined with radiotherapy in oligometastatic non-small cell lung cancer with EGFR mutations: a single-arm, multicenter, exploratory study (ChiCTR2600120895)
P2, N=84, The Fourth Hospital of Hebei Medical University; The Fourth Hospital of Hebei Medical University
2 days ago
New P2 trial • Circulating tumor DNA
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Semena (befotertinib)
2d
Pivotal study to evaluate YL202 versus Docetaxel in Patients with Locally Advanced or Metastatic EGFR Sensitive Mutation Non-Squamous Non-Small Cell Lung Cancer (ChiCTR2600120457)
P3, N=440, Shanghai Dongfang Hospital; Shanghai Dongfang Hospital
2 days ago
New P3 trial
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
docetaxel • BNT326
2d
Study on the incidence of venous thromboembolism in patients with locally advanced or metastatic NSCLC harboring EGFR-sensitive mutations treated with befotertinib with or without rivaroxaban (ChiCTR2600119885)
P4, N=1382, National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College; National Cancer Center/Cancer Hospital,Ch
2 days ago
New P4 trial
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion • EGFR T790M
|
Semena (befotertinib)
2d
Development and Application of a Novel Method for Therapeutic Drug Monitoring of Furmonertinib (ChiCTR2600119489)
P=N/A, N=50, Shanghai General Hospital; Shanghai General Hospital
2 days ago
New trial
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Ivesa (firmonertinib)
2d
MARIPOSA-2: A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure (clinicaltrials.gov)
P3, N=776, Active, not recruiting, Janssen Research & Development, LLC | Trial completion date: Sep 2026 --> Nov 2027
2 days ago
Trial completion date
|
EGFR (Epidermal growth factor receptor)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Tagrisso (osimertinib) • carboplatin • pemetrexed • Rybrevant (amivantamab-vmjw) • Lazcluze (lazertinib)
2d
An IIT, open-label, multi-arm, prospective clinical study to investigate the efficacy and safety of toripalimab combined with furmonertinib in non-small cell lung cancer patients with EGFR sensitive mutations and PD-L1 >= 1% of first-line treatment (ChiCTR2300076542)
P2, N=36, Recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University | Not yet recruiting --> Recruiting
2 days ago
Enrollment open • IO biomarker
|
EGFR (Epidermal growth factor receptor) • PD-L1 (Programmed death ligand 1)
|
EGFR mutation • EGFR L858R • EGFR exon 19 deletion
|
Loqtorzi (toripalimab-tpzi) • Ivesa (firmonertinib)
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