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GENE:

EGR1 (Early Growth Response 1)

News alerts, weekly reports and conference planners

Integrated transcriptomics and molecular docking identify hub genes and statin regulators in Helicobacter pylori-associated gastric mucosal pathogenesis. (PubMed, Front Cell Infect Microbiol)

To explore potential therapeutic interventions, we performed small-molecule drug prediction and molecular docking for hub genes revealed: Simvastatin: Linked to CCL20, NFKBIA, and ICAM1. Atorvastatin: Associated with CDKN1A, ICAM1, and TNF. TPCA-1: Targeting JAK1. These findings provide a theoretical foundation for further investigation into the molecular mechanisms underlying H. pylori-related diseases.

5 days ago

Journal

BRCA1 (Breast cancer 1, early onset) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • BIRC3 (Baculoviral IAP repeat containing 3) • JAK1 (Janus Kinase 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • CCL20 (C-C Motif Chemokine Ligand 20) • ICAM1 (Intercellular adhesion molecule 1) • IRF1 (Interferon Regulatory Factor 1) • ITGAM (Integrin, alpha M) • SPI1 (Spi-1 Proto-Oncogene) • ETS1 (ETS Proto-Oncogene 1) • IL17A (Interleukin 17A) • STAT1 (Signal Transducer And Activator Of Transcription 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • NFKB2 (Nuclear Factor Kappa B Subunit 2) • NFKBIA (NFKB Inhibitor Alpha 2) • NFKBIE (NFKB Inhibitor Epsilon) • TRAF1 (TNF Receptor Associated Factor 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • E2F1 (E2F transcription factor 1) • EGR1 (Early Growth Response 1) • HSF1 (Heat Shock Transcription Factor 1) • JUNB (JunB Proto-Oncogene AP-1 Transcription Factor Subunit)

simvastatin • atorvastatin

Loss of Early Growth Response Protein 1 in the Liver Leads to Hepatic Lipid Accumulation Driven by an Imbalance Between Fatty Acid β-Oxidation and Oxidative Phosphorylation. (PubMed, Gastro Hep Adv)

Fasting-induced hepatic lipid accumulation indeed indicated reduced fatty acid oxidation efficiency upon ablation of EGR1. Hepatic EGR1 deficiency significantly alters lipid metabolism and mitochondrial function, indicating a role of EGR1 in regulating the balance between mitochondrial fatty acid β-oxidation and respiration in the liver.

5 days ago

Journal

EGR1 (Early Growth Response 1)

Glycolytic-inflammatory crosstalk mediated by Glyco-PMF-Rux hub genes drives PMF progression and ruxolitinib resistance. (PubMed, Genes Genomics)

STAT1, EGR1, FOXO1, and SMAD7 are associated with glycolytic-inflammatory crosstalk underlying PMF progression and ruxolitinib resistance, with experimental validation supporting STAT1 and EGR1 as potential diagnostic and therapeutic targets.

8 days ago

Journal

STAT1 (Signal Transducer And Activator Of Transcription 1) • SMAD7 (SMAD Family Member 7) • EGR1 (Early Growth Response 1)

Jakafi (ruxolitinib)

12d

CAR-NK Cells (CL-NK-003) in Pancreatic Cancer (clinicaltrials.gov)

P1, N=9, Recruiting, Changhai Hospital

12 days ago

New P1 trial • First-in-human

EGR1 (Early Growth Response 1)

13d

Ganglioside GM2 induces epithelial-mesenchymal transition (EMT) in cancer cells in a MEK/ERK/Egr1-dependent transcriptional program. (PubMed, J Biol Chem)

Finally, Egr1 KO in HeLa cells further reduced the induction of mesenchymal marker expression in the presence of GM2, thereby confirming the role of Egr1 in GM2-induced EMT (epithelial-mesenchymal transition) process. Taken together, this study identified MEK-ERK-Egr1 axis as an important regulatory signaling in GM2-mediated EMT and pro-tumorigenic functions.

13 days ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • EGR1 (Early Growth Response 1)

17d

In vivo multiplexed modeling reveals diverse roles of the TBX2 subfamily and Egr1 in Kr as-driven lung adenocarcinoma. (PubMed, Genes Dis)

Transcriptomic analyses of Egr1-deficient tumors suggested immune dysregulation, including heightened inflammation and potential markers of T cell exhaustion in the tumor microenvironment. These findings indicate that Egr1 may play a role in suppressing tumor growth through modulating immune dynamics, offering new insights into the interplay between tumor progression and immune regulation in lung adenocarcinoma.

17 days ago

Preclinical • Journal

RB1 (RB Transcriptional Corepressor 1) • TNFAIP3 (TNF Alpha Induced Protein 3) • ATF3 (Activating Transcription Factor 3) • CHD2 (Chromodomain Helicase DNA Binding Protein 2) • EGR1 (Early Growth Response 1)

22d

Identification of DMP1 as Novel p53 Repressed Transcriptional Target. (PubMed, Int J Mol Sci)

Furthermore, chromatin immunoprecipitation demonstrated SP1 binding to the hDMP1 promoter. Together, our findings identify an Sp1-dependent, p53-mediated repression of DMP1.

22 days ago

Journal

EGR1 (Early Growth Response 1)

22d

Snail1 Induced Suppression of Proliferation via EGR1, FOXO1, and CEPBγ Creates a Vulnerability for Targeting Apoptotic and Cellular Senescence Pathways. (PubMed, Cancers (Basel))

We identified three new major downstream targets of Snail1 that improve our understanding of the role of EMT in limiting stress signaling, apoptosis, and senescence during cell cycle suppression to create a vulnerability for therapeutic targeting.

22 days ago

Journal

CASP3 (Caspase 3) • CCNB2 (Cyclin B2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • SNAI1 (Snail Family Transcriptional Repressor 1) • EGR1 (Early Growth Response 1) • SOD3 (Superoxide dismutase 3) • CCNG1 (Cyclin G1)

24d

Down-regulation of proliferation-inhibiting factor EGR1 in brain metastatic cancer cells on a soft matrix. (PubMed, Cell Struct Funct)

Additionally, EGR1 knockdown by siRNA transfection in WM266.4 cells results in promoted cell proliferation and downregulated TP53 on a soft ECM. These results suggest that brain metastatic WM266.4 cells decrease EGR1 expression, thereby promoting cell proliferation via TP53 downregulation on a soft ECM.Key words: EGR1, ECM stiffness, metastasis, cancer, growth.

24 days ago

Journal

EGR1 (Early Growth Response 1)

28d

Hepatocytes functionally reprogrammed by KIAA1199-high colorectal cancer cells favour the accumulation of pro-metastatic Egr1+ neutrophils. (PubMed, Nat Commun)

Furthermore, a combined KIAA1199-SAA2 signature predicts liver metastasis risk in patients. Our findings delineate a KIAA1199-PPARγ/SAA2-Egr1 axis orchestrating the pre-metastatic niche and propose metabolic normalization as a preventative strategy for liver metastasis.

28 days ago

Journal

SAA2 (Serum Amyloid A2) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • EGR1 (Early Growth Response 1)

Paclitaxel drives TREM2+ macrophage expansion underlying its inferior therapeutic efficacy compared to Nab-paclitaxel. (PubMed, Nat Commun)

Genetic ablation of Trem2 or pharmacologic targeting with antisense oligonucleotides suppress paclitaxel-induced breast cancer lung metastasis in vivo. Collectively, our findings demonstrate that paclitaxel, but not nab-paclitaxel, stimulates TREM2 expression and expands TREM2+ macrophages, suggesting that TREM2 targeting could enhance paclitaxel efficacy while limiting metastasis.

1 month ago

Journal

FGF2 (Fibroblast Growth Factor 2) • ATF3 (Activating Transcription Factor 3) • EGR1 (Early Growth Response 1) • TREM2 (Triggering Receptor Expressed On Myeloid Cells 2)

albumin-bound paclitaxel

Contact-compression induces inflammatory and remodeling responses in bronchial epithelial cells. (PubMed, Am J Physiol Lung Cell Mol Physiol)

We developed a viable in vitro model to study contact-compression, showing biomechanical inflammatory and remodeling responses. With adjustable components, this model can be applied to further study tissue responses to lung implants.

1 month ago

Journal

CXCL8 (Chemokine (C-X-C motif) ligand 8) • FN1 (Fibronectin 1) • CSF2 (Colony stimulating factor 2) • TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • IL1A (Interleukin 1, alpha) • CTGF (Connective tissue growth factor) • EGR1 (Early Growth Response 1)