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    CANCER:

    Endometrial Adenocarcinoma

    Related cancers:
    5d
    The Umbilical Clue: Recognizing Sister Mary Joseph's Nodule. (PubMed, Eur J Case Rep Intern Med)
    Clinical significance: Sister Mary Joseph's nodule (SMJN) represents a rare but important clinical sign of metastatic intra-abdominal or pelvic malignancy, often indicating advanced disease.Clinical awareness: Heightened awareness of umbilical lesions among clinicians is essential, particularly in elderly patients presenting with nonspecific systemic symptoms such as weight loss, asthenia, or abdominal pain.Early diagnosis of SMJN is essential, as it frequently signifies advanced metastatic disease. Prompt recognition allows timely initiation of appropriate therapy or palliative care to optimize patient outcomes.
    Journal
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    CDX2 (Caudal Type Homeobox 2) • PAX8 (Paired box 8)
    14d
    Risk of second non-breast primary cancer in Chinese breast cancer patients with germline BRCA1/2 pathogenic variants. (PubMed, Breast Cancer Res Treat)
    BRCA1/2 carriers exhibit a 2- to 3-fold higher risk of second primary cancer than non-carriers. Ovarian cancer represents the majority of second primary cancers in BRCA1 carriers, while BRCA2 carriers have a wider spectrum of second primary cancers.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset)
    20d
    mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and Ovarian (clinicaltrials.gov)
    P1, N=159, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Dec 2025 --> Jun 2026 | Trial primary completion date: Dec 2025 --> Jun 2026
    Trial completion date • Trial primary completion date
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    ER (Estrogen receptor) • PGR (Progesterone receptor) • BRCA (Breast cancer early onset) • MUC16 (Mucin 16, Cell Surface Associated)
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    BRCA mutation
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    Lynparza (olaparib) • Truqap (capivasertib) • vistusertib (AZD2014)
    1m
    Galectin-3 in endometrial small extracellular vesicles promotes cytotrophoblast cell fusion during the implantation phase. (PubMed, Cell Commun Signal)
    Our findings demonstrate that endometrial sEVs enriched in galectin-3 during the implantation phase promote CT differentiation into ST, underscoring a novel role for sEV-mediated protein delivery in regulating early placental development and suggesting potential diagnostic and therapeutic applications in reproductive medicine.
    Journal
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    LGALS3 (Galectin 3)
    1m
    Spectrum of Histopathological Changes in Abnormal Uterine Bleeding with Estrogen and Progesterone Receptor Expression in Endometrial Hyperplasia and Carcinoma. (PubMed, J Midlife Health)
    Serous papillary-type carcinoma also showed negative expression. Endometrial carcinoma showed reduced hormonal expression compared to endometrial hyperplasia.
    Journal
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    ER (Estrogen receptor) • PGR (Progesterone receptor)
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    ER negative
    1m
    A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, University of Florida | Initiation date: Nov 2025 --> Mar 2026
    Trial initiation date
    1m
    Oxidative Stress Influences Exosome Biogenesis by Inducing Cellular Senescence in Uterine Adenocarcinoma Ishikawa Cells. (PubMed, Iran J Med Sci)
    Cells were treated with 20 μM hydrogen peroxide (H2O2) for 4 days, and physicochemical properties of Exos were analyzed using dynamic light scattering (DLS), scanning electron microscope (SEM), and western blotting. The expression of genes such as ALIX, CD63, TSG101, Rab27a, and Rab27b, along with aging factor senescence-associated
    Journal
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    RAB27A (RAB27A, Member RAS Oncogene Family) • TSG101 (Tumor Susceptibility 101)
    2ms
    Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors (clinicaltrials.gov)
    P1, N=24, Recruiting, AstraZeneca | Trial completion date: Apr 2044 --> Nov 2043
    Trial completion date
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    KRAS (KRAS proto-oncogene GTPase)
    2ms
    PET/CT and Lymph Node Mapping in Finding Lymph Node Metastasis in Patients With High-Risk Endometrial Cancer (clinicaltrials.gov)
    P=N/A, N=101, Active, not recruiting, M.D. Anderson Cancer Center | N=150 --> 101
    Enrollment change
    2ms
    Naptumomab Estafenatox in Combination With Durvalumab in Subjects With Selected Advanced or Metastatic Solid Tumor, Including a Cohort Expansion in Esophageal Cancer. (clinicaltrials.gov)
    P1, N=120, Active, not recruiting, NeoTX Therapeutics Ltd. | Recruiting --> Active, not recruiting
    Enrollment closed
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • TPBG (Trophoblast Glycoprotein)
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    HER-2 negative
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    Imfinzi (durvalumab) • Gazyva (obinutuzumab) • Anyara (naptumomab estafenatox)
    2ms
    Clinicopathologic characteristics and prognostic outcomes of surgically treated neuroendocrine cervical carcinoma: A single institution retrospective analysis. (PubMed, Int J Gynaecol Obstet)
    NECC is a highly aggressive subtype of cervical cancer, frequently associated with HPV infection-particularly HPV18-and characterized by a high risk of lymph node metastasis and poor prognosis. NECC often coexists with other malignancies. ThinPrep cytology test (TCT) combined with HPV testing may be a potential method for early detection. Surgical resection followed by adjuvant chemotherapy and/or radiotherapy may be an effective treatment strategy for early-stage NECC. FIGO stage and the extent of multiple lymph node metastases are key prognostic factors.
    Retrospective data • Journal
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    NCAM1 (Neural cell adhesion molecule 1) • SYP (Synaptophysin)