estradiol valerate

Subjects were divided into three groups based on different estrogen formulations and administration routes: Group A [oral Estradiol Valerate Tablets (Progynova)], Group B (oral M17EH), and Group C (oral combined with vaginal M17EH)...For Groups B and C, endometrial tissue samples were collected five days after progesterone conversion...In FET cycles, a HRT regimen combining oral and vaginal administration of Micronized 17-beta estradiol hemihydrate is more conducive to endometrial growth. Although vaginal administration results in higher estrogen levels, it does not appear to compromise endometrial receptivity.

TG may improve memory ability while reducing oxidative stress and apoptosis. It also reduces Aβ protein deposition in the hippocampus, protecting the central nervous system and improving memory function. TG may reduce the risk of AD.

After verification of successful transplantation (42 days), the animals were co-treated for 7 days with estradiol valerate (E2V; 0.5 mg/kg and the aqueous (GPC) or methanolic (GPM) extracts of G. pictum at doses of 50 and 275 mg/kg. Positive controls received aspirin (3 mg/kg) or letrozole (10 mg/kg)...Apart from its ornamental worth, Graptophyllum pictum also called caricature plant, is traditionally used to relieve pain and treat reproductive disorders. After abdominal auto-transplantation of uterine fragments in rats, water-based and alcohol-based extracts of Graptophyllum pictum promoted fertility by improving menstrual pain, egg development; and reducing cell damage and inflammation, which contribute to the progression of endometriosis.

Oral administration of estradiol valerate followed by D&C demonstrates superior clinical efficacy in the management of missed abortion during early pregnancy. This can enhance cervical dilation, facilitate abortion, modulate estrogen levels, promote endometrial repair, and relieve inflammation.

P2, N=24, Not yet recruiting, Universiti Kebangsaan Malaysia Medical Centre

P4, N=554, Completed, Universitaire Ziekenhuizen KU Leuven | Recruiting --> Completed | Trial primary completion date: Apr 2024 --> Nov 2024

The estrogen group was administered intragastrically with estradiol valerate of 4.2 mg·kg~(-1)...Western blot results showed that the protein expressions of Notch and ADAM17 in high-dose, medium-dose and low-dose of Bushen Huoxu Formula groups were significantly down-regulated in a dose-dependent manner. These results suggest that Bushen Huoxue Formula may inhibit fibrosis process through ADAM17/Notch signaling pathway, suggesting that Bushen Huoxuet Formula is one of the potential therapeutic methods for IUA.

P4, N=362, Terminated, CRG UZ Brussel | Trial completion date: Dec 2025 --> Jan 2025 | Active, not recruiting --> Terminated | Trial primary completion date: Sep 2025 --> Jan 2025; safety

P=N/A, N=20, Active, not recruiting, Thai Red Cross AIDS Research Centre | Trial primary completion date: Oct 2023 --> Jan 2024

P4, N=362, Active, not recruiting, CRG UZ Brussel | Recruiting --> Active, not recruiting | N=522 --> 362

P=N/A, N=290, Not yet recruiting, Peking University Third Hospital; Peking University Third Hospital

P3, N=120, Not yet recruiting, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences; Peking Union Medical College Hospital, Chinese Academy of Medical Sciences