Osteoporosis is common in postmenopausal women due to reduced estrogen levels and leads to weaker bones. Alendronate is widely prescribed to lower fracture risk, but it may interfere with bone healing after dental procedures such as tooth extraction. Using a rat model that mimics postmenopausal bone loss, this study examined how estrogen deficiency, alendronate treatment, and estrogen replacement together influence healing of the tooth socket, a process highly relevant to periodontal and oral surgical care. The results showed that estrogen deficiency alone already compromised bone repair, and this effect became more pronounced when alendronate was used. Estrogen replacement with estradiol valerate did not fully restore normal healing, but it reduced several harmful changes in bone structure and local inflammatory activity associated with alendronate. Importantly, no bone necrosis was observed under the conditions studied, although persistent disturbances in bone remodeling were evident. These findings help clarify how systemic bone conditions and osteoporosis treatments can influence periodontal wound healing and support more informed risk assessment and interdisciplinary planning when dental extractions are required in patients with osteoporosis.

16 days ago

Preclinical • Journal • Adverse events

TNFA (Tumor Necrosis Factor-Alpha) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B) • TNFSF11 (TNF Superfamily Member 11)

estradiol valerate

17d

Topical Vaginal Estrogen for Postpartum Obstetric Anal Sphincter Injury Recovery (clinicaltrials.gov)

P4, N=38, Terminated, University of Alabama at Birmingham | Trial completion date: Jul 2026 --> Feb 2026 | Recruiting --> Terminated; Ran out of funding

17 days ago

Trial completion date • Trial termination

25d

CC-OVI: Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction (clinicaltrials.gov)

P=N/A, N=90, Completed, Yuzuncu Yil University

25 days ago

New trial

26d

Effect of Vaginal Estrogen on Alterations in the Urine Microbiome of Menopausal Women With Overactive Bladder (clinicaltrials.gov)

P4, N=30, Completed, Mahidol University | Not yet recruiting --> Completed

26 days ago

Trial completion

Impact of Estradiol on Endothelial Function in Peri-Menopausal Women (clinicaltrials.gov)

P4, N=80, Active, not recruiting, University of Delaware | Recruiting --> Active, not recruiting | Trial completion date: Dec 2025 --> Jun 2026 | Trial primary completion date: Dec 2025 --> May 2026

1 month ago

Enrollment closed • Trial completion date • Trial primary completion date

A Study Comparing Different Treatment Approaches for the Initiation of Puberty in Girls With Turner Syndrome Using a TRIFECTA-DARED Approach for Rare Diseases (clinicaltrials.gov)

P2, N=24, Not yet recruiting, Universiti Kebangsaan Malaysia Medical Centre | Initiation date: Jul 2025 --> Feb 2026

1 month ago

Trial initiation date

estradiol valerate

Ovulation induction with oral contraception alone in biochemical to overt primary ovarian insufficiency: a pilot study. (ChiCTR2500111618)

P=N/A, N=32, Not yet recruiting, Xiangya Hospital, Central South University; Xiangya Hospital, Central South University

1 month ago

New trial

PHOENIX: Plasma Oxytocin Response to Oral Estrogens in Healthy Controls and AVP-Deficiency (clinicaltrials.gov)

P=N/A, N=28, Recruiting, University Hospital, Basel, Switzerland

1 month ago

New trial

estradiol valerate

Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections (clinicaltrials.gov)

P4, N=111, Active, not recruiting, University of California, Irvine | Recruiting --> Active, not recruiting | Trial primary completion date: Jan 2027 --> Jun 2027

1 month ago

Enrollment closed • Trial primary completion date

Estring (estradiol)