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    DRUG CLASS:

    Estrogen receptor agonist

    Related drugs:
    2d
    Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer (clinicaltrials.gov)
    P2, N=5, Active, not recruiting, Mayo Clinic | Trial completion date: Jul 2026 --> Dec 2026
    Trial completion date
    |
    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • PGR (Progesterone receptor)
    |
    HER-2 negative
    15d
    Contraceptive Efficacy and Safety of NOMAC-E2 Combined Oral Contraceptive (clinicaltrials.gov)
    P3, N=3055, Terminated, Organon and Co | N=2007 --> 3055
    Enrollment change
    22d
    Estrogen Supplementation and Bone Health in Women With CF (clinicaltrials.gov)
    P4, N=75, Recruiting, Johns Hopkins University | Trial completion date: Dec 2025 --> Jan 2027 | Trial primary completion date: Dec 2025 --> Jan 2027
    Trial completion date • Trial primary completion date
    25d
    Estrogen Hormone Products (clinicaltrials.gov)
    P1, N=8, Completed, University of Maryland, Baltimore | Recruiting --> Completed | N=12 --> 8
    Trial completion • Enrollment change
    |
    Divigel (estradiol)
    1m
    Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse (clinicaltrials.gov)
    P4, N=7, Terminated, The University of Texas Medical Branch, Galveston | N=10 --> 7
    Enrollment change
    2ms
    Clinical outcomes of different 17β-estradiol drug regimens and their impact on endometrial receptivity. (PubMed, Front Endocrinol (Lausanne))
    Subjects were divided into three groups based on different estrogen formulations and administration routes: Group A [oral Estradiol Valerate Tablets (Progynova)], Group B (oral M17EH), and Group C (oral combined with vaginal M17EH)...For Groups B and C, endometrial tissue samples were collected five days after progesterone conversion...In FET cycles, a HRT regimen combining oral and vaginal administration of Micronized 17-beta estradiol hemihydrate is more conducive to endometrial growth. Although vaginal administration results in higher estrogen levels, it does not appear to compromise endometrial receptivity.
    Clinical data • Retrospective data • Journal
    |
    MUC1 (Mucin 1) • LIF (LIF Interleukin 6 Family Cytokine)
    |
    estradiol valerate
    2ms
    Surgical Myomectomy Followed by Oral Myfembree Versus Standard of Care Trial (SOUL) (clinicaltrials.gov)
    P4, N=0, Withdrawn, University of Chicago | N=136 --> 0 | Terminated --> Withdrawn
    Enrollment change • Trial withdrawal
    2ms
    Mechanism of Tiaogeng decoction in a cognitive dysfunction mouse model. (PubMed, J Tradit Chin Med)
    TG may improve memory ability while reducing oxidative stress and apoptosis. It also reduces Aβ protein deposition in the hippocampus, protecting the central nervous system and improving memory function. TG may reduce the risk of AD.
    Preclinical • Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • NFE2L2 (Nuclear Factor, Erythroid 2 Like 2) • HMOX1 (Heme Oxygenase 1) • APP (Amyloid Beta Precursor Protein) • CASP9 (Caspase 9) • MAPK8 (Mitogen-activated protein kinase 8)
    |
    estradiol valerate
    3ms
    Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain (clinicaltrials.gov)
    P3, N=130, Recruiting, University of Michigan | Initiation date: Aug 2025 --> Nov 2025
    Trial initiation date
    |
    CCL3 (C-C Motif Chemokine Ligand 3)
    |
    Orgovyx (relugolix)
    3ms
    A Study to Evaluate Changes in Hair in Adult Participants Taking Oral Oriahnn Capsules With Heavy Menstrual Bleeding (HMB) Associated With Uterine Fibroids (UF) (clinicaltrials.gov)
    P=N/A, N=0, Withdrawn, AbbVie | N=1600 --> 0 | Enrolling by invitation --> Withdrawn
    Enrollment change • Trial withdrawal
    3ms
    The Impact of a Novel GnRH Antagonist With Add-back Therapy for Treatment of Uterine Fibroids and Endometriosis on Hemostasis Parameters (clinicaltrials.gov)
    P=N/A, N=30, Recruiting, University Hospital, Geneva
    New trial
    3ms
    Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation (clinicaltrials.gov)
    P4, N=120, Recruiting, University of Southern California | Not yet recruiting --> Recruiting | N=60 --> 120 | Trial primary completion date: Sep 2025 --> Mar 2026
    Enrollment open • Enrollment change • Trial primary completion date