^
    5ms
    Design and Discovery of Novel Selective RET Inhibitors with High Central Nervous System Penetration, Enhanced Pharmacokinetics, and Pharmacodynamics. (PubMed, J Med Chem)
    Western blot analysis indicated that compound FHND5071 significantly inhibited the phosphorylation of RET and downstream molecules ERK and AKT in tumor tissues. Furthermore, compound FHND5071 markedly inhibited tumor growth, showing good in vivo efficacy and significant intracranial antitumor activity.
    PK/PD data • Journal
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    RET (Ret Proto-Oncogene)
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    RET mutation • RET rearrangement
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    FHND5071