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flonoltinib
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Company:
Baoling Bio
Drug class:
JAK2 inhibitor, FLT3 inhibitor, CDK6 inhibitor
Related drugs:
16d
Phase IIa Study on Flonoltinib Maleate Tablets in the Treatment of Patients With Polycythemia Vera (clinicaltrials.gov)
P2, N=60, Active, not recruiting, Chengdu Zenitar Biomedical Technology Co., Ltd
New P2 trial • Tumor mutational burden
|
hydroxyurea • flonoltinib
2ms
Safety of Flonoltinib Maleate Tablets for the Treatment of Patients With Myeloproliferative (clinicaltrials.gov)
P1/2, N=31, Completed, Chengdu Zenitar Biomedical Technology Co., Ltd | Recruiting --> Completed | Trial completion date: Dec 2023 --> Mar 2025
Trial completion • Trial completion date
|
flonoltinib
2ms
A Pharmacokinetic Study of the Food Effect on Flonoltinib Maleate Tablets (clinicaltrials.gov)
P1, N=24, Completed, Chengdu Zenitar Biomedical Technology Co., Ltd
New P1 trial
|
flonoltinib
3ms
A Phase I Clinical Study of Flonoltinib Maleate Tablets in Healthy Subjects (clinicaltrials.gov)
P1, N=40, Completed, Chengdu Zenitar Biomedical Technology Co., Ltd | Recruiting --> Completed
Trial completion
|
flonoltinib
over1year
Flunotinib Maleate Phase II Intermediate-High Risk Bone Fiber Clinical Trial (clinicaltrials.gov)
P2, N=75, Recruiting, Chengdu Zenitar Biomedical Technology Co., Ltd
New P2 trial
|
Jakafi (ruxolitinib) • flonoltinib
almost2years
Study on tissue distribution, metabolite profiling, and excretion of [C]-labeled flonoltinib maleate in rats. (PubMed, J Pharm Biomed Anal)
A minor fraction of FM (<10 %) was excreted through renal excretion in the form of urine. Integration of the current results with previous pharmacokinetic investigations of FM in rats and dogs enables a comprehensive elucidation of the in vivo ADME processes and characteristics of FM, thereby establishing a solid foundation for subsequent clinical investigations of FM.
Preclinical • Journal
|
FLT3 (Fms-related tyrosine kinase 3) • JAK2 (Janus kinase 2)
|
flonoltinib
almost3years
Study of Flonoltinib Maleate Tablets in the Treatment of Severe Novel Coronavirus (COVID-19) Infection (clinicaltrials.gov)
P=N/A, N=66, Recruiting, Chengdu Zenitar Biomedical Technology Co., Ltd
New trial
|
IL6 (Interleukin 6)
|
flonoltinib
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