^
    8d
    AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients With Borderline Resectable, Locally Advanced or Metastatic Cholangiocarcinoma or Pancreatic Cancer (clinicaltrials.gov)
    P1, N=46, Not yet recruiting, Jonsson Comprehensive Cancer Center
    New P1 trial
    |
    cisplatin • Imfinzi (durvalumab) • gemcitabine • oxaliplatin • irinotecan • Yutuo (zimberelimab) • leucovorin calcium • fluorouracil topical
    8d
    Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy (clinicaltrials.gov)
    P1/2, N=60, Recruiting, Mayo Clinic | Not yet recruiting --> Recruiting
    Enrollment open
    |
    capecitabine • fluorouracil topical
    19d
    A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes, INSPIRE Trial (clinicaltrials.gov)
    P2, N=11, Active, not recruiting, National Cancer Institute (NCI) | N=95 --> 11 | Trial completion date: Jun 2026 --> May 2027 | Trial primary completion date: Jun 2026 --> Feb 2026
    Enrollment change • Trial completion date • Trial primary completion date
    |
    cisplatin • Imfinzi (durvalumab) • gemcitabine • Jelmyto (mitomycin urothelial gel) • fluorouracil topical
    22d
    S1513: FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer (clinicaltrials.gov)
    P2, N=123, Completed, National Cancer Institute (NCI) | Active, not recruiting --> Completed
    Trial completion
    |
    CEACAM5 (CEA Cell Adhesion Molecule 5)
    |
    irinotecan • veliparib (ABT-888) • leucovorin calcium • fluorouracil topical
    24d
    A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction Cancers (clinicaltrials.gov)
    P1, N=25, Completed, Massachusetts General Hospital | Trial completion date: Feb 2024 --> Apr 2026
    Trial completion date
    |
    carboplatin • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    1m
    New and Emerging Therapies for the Treatment of Resectable, Borderline Resectable, or Locally Advanced Pancreatic Cancer, PIONEER-Panc Study (clinicaltrials.gov)
    P2, N=0, Withdrawn, M.D. Anderson Cancer Center | N=105 --> 0 | Trial completion date: Apr 2027 --> Apr 2026 | Active, not recruiting --> Withdrawn | Trial primary completion date: Apr 2027 --> Apr 2026
    Enrollment change • Trial completion date • Trial withdrawal • Trial primary completion date
    |
    cisplatin • gemcitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    1m
    Oxaliplatin, Leucovorin, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer (clinicaltrials.gov)
    P3, N=2431, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Apr 2026 --> Apr 2027
    Trial completion date
    |
    MSI (Microsatellite instability) • MSH2 (MutS Homolog 2)
    |
    Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • fluorouracil topical
    1m
    Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma (clinicaltrials.gov)
    P1/2, N=35, Recruiting, Roswell Park Cancer Institute | Trial primary completion date: Oct 2027 --> Feb 2028
    Trial primary completion date
    |
    oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    1m
    Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer (clinicaltrials.gov)
    P3, N=236, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2026 --> Mar 2027
    Trial completion date
    |
    AFP (Alpha-fetoprotein)
    |
    AFP elevation
    |
    cisplatin • doxorubicin hydrochloride • irinotecan • temsirolimus • vincristine • fluorouracil topical • dexrazoxane
    1m
    Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov)
    P3, N=403, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Feb 2026 --> Feb 2027
    Trial completion date
    |
    Avastin (bevacizumab) • cisplatin • carboplatin • docetaxel • Aybintio (bevacizumab biosimilar) • Vegzelma (bevacizumab-adcd) • Avzivi (bevacizumab-tnjn) • fluorouracil topical
    2ms
    Adjuvant 5-Fluorouracil Following Thermal Ablation to Improve HPV Treatment Outcomes in Women With HIV in Kenya (clinicaltrials.gov)
    P2, N=140, Not yet recruiting, UNC Lineberger Comprehensive Cancer Center
    New P2 trial
    |
    fluorouracil topical
    2ms
    PHOX: Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma (clinicaltrials.gov)
    P2, N=99, Recruiting, Mayo Clinic | Trial completion date: May 2031 --> May 2027 | Trial primary completion date: May 2031 --> May 2027
    Trial completion date • Trial primary completion date
    |
    Imfinzi (durvalumab) • docetaxel • oxaliplatin • leucovorin calcium • fluorouracil topical