^
    10d
    A Pilot Study of FOLFIRINOX in Combination With Neoadjuvant Radiation for Gastric and GE Junction Cancers (clinicaltrials.gov)
    P1, N=25, Completed, Massachusetts General Hospital | Active, not recruiting --> Completed
    Trial completion
    |
    carboplatin • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    21d
    NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer (clinicaltrials.gov)
    P2, N=60, Active, not recruiting, OHSU Knight Cancer Institute | Trial completion date: Oct 2025 --> Jan 2027 | Trial primary completion date: Apr 2025 --> Dec 2024
    Trial completion date • Trial primary completion date
    |
    gemcitabine • capecitabine • albumin-bound paclitaxel • oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    24d
    PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer (clinicaltrials.gov)
    P1, N=49, Recruiting, City of Hope Medical Center | Trial completion date: Aug 2026 --> Jan 2028 | Trial primary completion date: Aug 2026 --> Jan 2028
    Trial completion date • Trial primary completion date
    |
    cisplatin • paclitaxel • doxorubicin hydrochloride • albumin-bound paclitaxel • oxaliplatin • irinotecan • daunorubicin • leucovorin calcium • Jelmyto (mitomycin urothelial gel) • fluorouracil topical
    24d
    NCI-2022-09458: FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer (clinicaltrials.gov)
    P1/2, N=20, Active, not recruiting, City of Hope Medical Center | Trial completion date: Oct 2025 --> Jun 2026 | Trial primary completion date: Oct 2025 --> Jun 2026
    Trial completion date • Trial primary completion date
    |
    POLE (DNA Polymerase Epsilon)
    |
    POLE mutation
    |
    Avastin (bevacizumab) • oxaliplatin • leucovorin calcium • balstilimab (AGEN2034) • botensilimab (AGEN1181) • fluorouracil topical
    24d
    Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer (clinicaltrials.gov)
    P1, N=25, Recruiting, Jonsson Comprehensive Cancer Center | Trial completion date: Oct 2026 --> Oct 2027 | Trial primary completion date: Oct 2025 --> Oct 2026
    Trial completion date • Trial primary completion date
    |
    Signatera™
    |
    capecitabine • oxaliplatin • leucovorin calcium • fluorouracil topical
    29d
    2 Versus 6 Hour Oxaliplatin Infusions in Patients With Gastrointestinal Cancers (clinicaltrials.gov)
    P2, N=60, Recruiting, Emory University | Trial primary completion date: Sep 2025 --> Aug 2026
    Trial primary completion date
    |
    oxaliplatin • leucovorin calcium • fluorouracil topical
    1m
    NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer (clinicaltrials.gov)
    P1, N=24, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Oct 2025 --> Oct 2027 | Trial primary completion date: Oct 2025 --> Oct 2027
    Trial completion date • Trial primary completion date
    |
    carboplatin • paclitaxel • docetaxel • capecitabine • oxaliplatin • leucovorin calcium • fluorouracil topical • Hensify (crystalline hafnium oxide)
    2ms
    A Pilot Clinical Trial Comparing Topical Fluorouracil to Fluorouracil Plus Calcipotriene Field Treatments in Patients With Multiple Actinic Keratoses (clinicaltrials.gov)
    P3, N=30, Recruiting, M.D. Anderson Cancer Center | Not yet recruiting --> Recruiting | Initiation date: May 2026 --> Oct 2025
    Enrollment open • Trial initiation date
    |
    fluorouracil topical
    2ms
    Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma (clinicaltrials.gov)
    P1/2, N=35, Not yet recruiting, Roswell Park Cancer Institute
    New P1/2 trial
    |
    oxaliplatin • irinotecan • leucovorin calcium • fluorouracil topical
    2ms
    TOPGEAR: Trial of Preoperative Therapy for Gastric and Esophagogastric Junction Adenocarcinoma (clinicaltrials.gov)
    P2/3, N=574, Completed, Australasian Gastro-Intestinal Trials Group | Active, not recruiting --> Completed
    Trial completion
    |
    cisplatin • docetaxel • capecitabine • oxaliplatin • epirubicin • leucovorin calcium • fluorouracil topical
    2ms
    NCI-2018-01810: Docetaxel, Cisplatin and Fluorouracil in Treating Patients With Previously Untreated Stage II-IV Nasal Cavity and Paranasal Sinus Cancer (clinicaltrials.gov)
    P2, N=31, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Sep 2025 --> Sep 2027 | Trial primary completion date: Sep 2025 --> Sep 2027
    Trial completion date • Trial primary completion date
    |
    cisplatin • carboplatin • docetaxel • fluorouracil topical
    2ms
    Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients (clinicaltrials.gov)
    P2, N=56, Active, not recruiting, University of Arizona | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    fluorouracil topical