fluoxetine

P2, N=800, Recruiting, Global Coalition for Adaptive Research | Trial completion date: Sep 2026 --> Jul 2029 | Trial primary completion date: Mar 2026 --> Jul 2028

Female Sprague-Dawley rats (3-4 weeks) were randomly divided into four groups (n=7-8): control (CON), chronic unpredictable mild stress (CUMS), CUMS + TPM-like manipulations (TPM), and CUMS + fluoxetine (FLX)...TPM-like manipulations prevented CUMS-induced depressive-like behaviors, increased concentration of L-Aspartic Acid, increased the expressions of GHR and IGF-1 in the liver, increased the expressions of IGF-1 and IGF-1R, and inhibited inflammation in the hippocampus in adolescent female rats. However, further study is warranted to draw confirmative results related to liver-brain axis.

P4, N=100, Recruiting, Wake Forest University Health Sciences | Trial completion date: May 2026 --> May 2027 | Trial primary completion date: May 2026 --> May 2027

P3, N=1500, Active, not recruiting, Harvard Medical School (HMS and HSDM) | Recruiting --> Active, not recruiting | Trial completion date: Mar 2027 --> Dec 2026

P2, N=200, Suspended, Global Coalition for Adaptive Research | Trial completion date: Sep 2026 --> May 2028 | Recruiting --> Suspended | Trial primary completion date: Mar 2026 --> May 2028

P2, N=60, Recruiting, Stanford University | Trial completion date: Dec 2026 --> Dec 2028 | Trial primary completion date: Apr 2026 --> Apr 2027

P3, N=60, Recruiting, Tanta University | Trial completion date: Aug 2026 --> Aug 2027 | Trial primary completion date: Mar 2026 --> Mar 2027

Together, our results suggest that early life overfeeding deregulates oxidative balance and mitochondrial biogenesis, wherein FX administration acts toward molecular normalization both in heart and brainstem of male offspring. These ndings shed light on the potential of serotonin modulation to mitigate the effects of overnutrition during developmental periods.

After a triple-paradigm successive traumatic process of SPS and mice isolation for 7 days, they were treated as control (saline 10 mL/kg, p.o), SPS, SPS + silymarin (25, 50, 100 mg/kg, p.o), and SPS + fluoxetine (10 mg/kg, p.o) groups from days 8-21...Notably, silymarin significantly reduced GFAP expression in the prefrontal cortex as well as in the hippocampal CA3 subregion. These findings demonstrate that silymarin exerts anti-PTSD-like effects through the enhancement of monoaminergic concentrations, suppression of neuroinflammation, and restoration of astrocytic function.

P=N/A, N=411, Peking University Sixth Hospital ( Institute of Mental Health ); Peking University Sixth Hospital ( Institute of Mental Health )

P=N/A, N=214, Recruiting, Peking University Sixth Hospital; Peking University Sixth Hospital

The control group received 0.5 ml of normal saline, CUMS rats were only exposed to CUMS daily, CUMS + fluoxetine rats were exposed to CUMS and orally received 10 mg/kg per body weight of fluoxetine daily, CUMS + 6-GIRPOG (100) and CUMS + 6-GIRPOG (200) rats were exposed to CUMS and orally received 100 and 200 mg/kg body weight of 6-GIRPOG respectively (daily)...However, the administration of both 100 and 200 mg/kg of 6-GIRPOG effectively reversed these behavioral and biochemical changes. Consequently, the study reveals the role of 6-GIRPOG in ameliorating CUMS-induced depression and brain damage via antioxidative, anti-inflammatory, and neurotransmission modulatory mechanisms.