fluoxetine

Rats were randomly assigned to control, model, SSa treatment, and fluoxetine-positive control groups...Mechanistically, SSa restored depleted hippocampal 5-HT levels, reduced pro-inflammatory cytokines expression (TNF-α, IL-6, IL-1β), and suppressed NF-κB p65 activation. These findings demonstrate that SSa exerts therapeutic effect against PTSD-like behavior through dual mechanisms: restoration of hippocampal serotonergic neurotransmission and suppression of NF- κB- mediated neuroinflammation, positioning SSa as a promising candidate for PTSD treatment.

P1/2, N=60, Recruiting, Tanta University | Not yet recruiting --> Recruiting

P=N/A, N=296, Recruiting, University of Bern | Active, not recruiting --> Recruiting

P1/2, N=60, Not yet recruiting, Tanta University

Furthermore, reported LDH allosteric inhibitors, including cGmC9 and fluoxetine, preferentially inhibited LDHBtr compared to the native LDHB, by preventing tetramer formation. Overall, this work highlights the central role of tetramerization in regulating LDH activity, and the therapeutic potential of targeting this process. It also establishes LDHBtr as a valuable tool for screening tetramerization disruptors, paving the way for next-generation LDH inhibitors to target cancer metabolism.

Despite these phenotypic changes, acute 5-HT treatment does not impair the effectiveness of tamoxifen in vitro. In vivo, administration of fluoxetine, a selective serotonin reuptake inhibitor, accelerates tumor growth and increases malignancy in a murine model. These findings underscore the ability of 5-HT to reprogram hormone receptors expression profiles and to promote a more aggressive cancer phenotype.

SeBZF1 (50 mg/kg, intragastrically) or fluoxetine (20 mg/kg, intraperitoneally, i.p, positive control) was administered 30 min before LPS (0.83 mg/kg, i.p.), and behavior assessed 24 h later...SeBZF1 also downregulated cortical IL-4 expression. Overall, SeBZF1 demonstrated antidepressant-like, antioxidant, and anti-inflammatory effects, supporting its potential as a candidate for depression associated with neuroinflammation.

P=N/A, N=160, Not yet recruiting, Shanghai Sixth People's Hospital; Shanghai Sixth People's Hospital

P4, N=200, Recruiting, Beijing Anding Hospital, Capital Medical University; Beijing Anding Hospital, Capital Medical University

P=N/A, N=120, Not yet recruiting, Children's Hospital of Soochow University; Children's Hospital of Soochow University

SZRD alleviated CRS-induced anxiety- and depression-like behaviors in mice by modulating the excitability and synaptic transmission of BLA pyramidal neurons.

The cultured cells were divided into five groups: blank control group, CORT group(400 μmol·L~(-1) CORT), Chaihu Shugan San-containing serum group(400 μmol·L~(-1) CORT + 10% Chaihu Shugan San-containing serum), control serum group(400 μmol·L~(-1) CORT + 10% control serum), and fluoxetine group(400 μmol·L~(-1) CORT + 10% fluoxetine-containing serum)...However, only Chaihu Shugan San-containing serum could significantly inhibit the CORT-induced upregulation protein of PGC-1α. : herein suggest that Chaihu Shugan San-containing serum can alleviate CORT-induced damage in PC12 cells, which may be related to the mitochondrial fragmentation/lipid peroxidation protection by Drp1 inhibition, as well as mitochondrial dynamics and energy metabolism mediated by PGC-1α/SIRT1 signaling pathway.