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DRUG:

Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)

i
Other names: V503, 9vHPV, V-503, V 503
Associations
Company:
Chongqing Zhifei, Merck (MSD)
Drug class:
Immunostimulant
Related drugs:
Associations
6d
GARDASIL 9: 3 Dose vs. 2 Dose With Delayed 3rd Dose (clinicaltrials.gov)
P4, N=767, Completed, The University of Texas Medical Branch, Galveston | Active, not recruiting --> Completed
Trial completion
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
7d
New trial
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
13d
Human papillomavirus (HPV) seroprevalence, cervical HPV prevalence and cervical lesions in systemic lupus erythematosus (SLE) and immunocompetent women. (PubMed, Lupus Sci Med)
Our findings underscore the importance of tailored cervical cancer screening and HPV vaccination of SLE women at young age.
Journal
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PapilloCheck®
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
21d
Preventive Human Papillomavirus (HPV) Vaccine Trial in Kidney Transplant Recipients (clinicaltrials.gov)
P2, N=51, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Mar 2026 --> Mar 2027
Trial completion date
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
26d
Trial initiation date
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TRIP13 (Thyroid Hormone Receptor Interactor 13)
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
28d
Enrollment open
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TRIP13 (Thyroid Hormone Receptor Interactor 13)
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
1m
HPV2-2303: Clinical Trial Evaluating Secondary HPV Vaccination After Treatment of High-grade Cervical Lesions (clinicaltrials.gov)
P2, N=85, Recruiting, Centre Oscar Lambret | Trial completion date: Oct 2031 --> Dec 2031
Trial completion date
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
1m
A Trial to Evaluate Tolerability and Immunogenicity of V540D in Healthy Adults (V540D-004) (clinicaltrials.gov)
P1, N=72, Active, not recruiting, Merck Sharp & Dohme LLC | Recruiting --> Active, not recruiting
Enrollment closed
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
1m
Recombinant Human Papillomavirus Nonavalent Vaccine in Preventing Human Papilloma Virus in Younger Healthy Participants (clinicaltrials.gov)
P2, N=201, Active, not recruiting, National Cancer Institute (NCI) | Trial completion date: Jan 2026 --> Jan 2027
Trial completion date
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
2ms
New P2 trial
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TRIP13 (Thyroid Hormone Receptor Interactor 13)
|
Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)
2ms
The magnitude and durability of neutralizing antibody responses to human papillomavirus vaccine do not depend on DNA sensing pathways. (PubMed, J Virol)
We confirmed separate lots of the 9vHPV vaccine contained low copy numbers of L1 DNA, but found 9vHPV vaccine-generated antibody responses were not dependent on DNA sensing. This study has thus refined our understanding of potential mechanisms underlying the strong and long-lasting antibody responses to HPV vaccination.
Journal
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MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • STING (stimulator of interferon response cGAMP interactor 1) • TLR9 (Toll Like Receptor 9)
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Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant)