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    DRUG CLASS:

    GAS6 inhibitor

    Related drugs:
    13d
    AXL inhibition improves the therapeutic efficacy of trastuzumab in high-risk endometrial cancer. (PubMed, Gynecol Oncol)
    Our findings support the combination of batiraxcept and trastuzumab as a promising therapeutic strategy for aggressive HER2+ endometrial cancer.
    Journal
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    LDHA (Lactate dehydrogenase A) • AURKA (Aurora kinase A)
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    HER-2 expression
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    Herceptin (trastuzumab) • batiraxcept (AVB-500)
    1m
    COAXIN: Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma (clinicaltrials.gov)
    P1, N=19, Active, not recruiting, University of Oklahoma | Trial completion date: Sep 2025 --> Feb 2026
    Trial completion date
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    Bavencio (avelumab) • batiraxcept (AVB-500)
    5ms
    Phase 1b/2 study of batiraxcept alone and in combination with cabozantinib with or without nivolumab for advanced clear cell renal cell carcinoma. (PubMed, Oncologist)
    Batiraxcept was well tolerated with promising early efficacy signal when combined with cabozantinib, especially in heavily pretreated patients with ccRCC. The trial was discontinued early due to the sponsor's internal decision.
    P1/2 data • Journal
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    AXL (AXL Receptor Tyrosine Kinase) • GAS6 (Growth arrest specific 6)
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    Opdivo (nivolumab) • Cabometyx (cabozantinib tablet) • batiraxcept (AVB-500)
    6ms
    AVB-S6-500 and Durvalumab in Treating Patients With Platinum-Resistant or Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (clinicaltrials.gov)
    P1/2, N=12, Terminated, M.D. Anderson Cancer Center | Completed --> Terminated; PI Request
    Trial termination • Platinum resistant
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    Imfinzi (durvalumab) • batiraxcept (AVB-500)
    10ms
    COAXIN: Avelumab in Combination With AVB-S6-500 in Patients With Advanced Urothelial Carcinoma (clinicaltrials.gov)
    P1, N=19, Active, not recruiting, University of Oklahoma | Trial completion date: Sep 2024 --> Sep 2025
    Trial completion date
    |
    Bavencio (avelumab) • batiraxcept (AVB-500)
    10ms
    Targeting AXL inhibits the growth and metastasis of prostate cancer in bone. (PubMed, Clin Cancer Res)
    Our study provides a robust preclinical rationale and mechanisms of action for using batiraxcept as a single agent or in combination with docetaxel or carboplatin to treat lethal mPCa.
    Journal
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    ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • E2F1 (E2F transcription factor 1) • TACSTD2 (Tumor Associated Calcium Signal Transducer 2)
    |
    carboplatin • docetaxel • batiraxcept (AVB-500)
    1year
    AVB-S6-500 and Durvalumab in Treating Patients With Platinum-Resistant or Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (clinicaltrials.gov)
    P1/2, N=12, Completed, M.D. Anderson Cancer Center | Active, not recruiting --> Completed | Trial completion date: Aug 2025 --> Oct 2024
    Trial completion • Trial completion date
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    Imfinzi (durvalumab) • batiraxcept (AVB-500)
    1year
    CD73 promotes non-small cell lung cancer metastasis by regulating Axl signaling independent of GAS6. (PubMed, Proc Natl Acad Sci U S A)
    We also identified the distinct function of CD73 activity in adenocarcinoma and squamous cell carcinoma. Our findings indicated a role of CD73 in mediating NSCLC metastasis and propose it as a therapeutic target for NSCLC.
    Journal
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    AXL (AXL Receptor Tyrosine Kinase) • CD73 (5'-Nucleotidase Ecto) • GAS6 (Growth arrest specific 6) • CBLB (Cbl Proto-Oncogene B) • SMAD3 (SMAD Family Member 3)
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    AXL expression • CD73 expression
    1year
    AVB-500 (Batiraxcept) in Combination With Paclitaxel in Recurrent High Grade Uterine Cancer (clinicaltrials.gov)
    P1, N=0, Withdrawn, Washington University School of Medicine | N=36 --> 0 | Not yet recruiting --> Withdrawn
    Enrollment change • Trial withdrawal
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    HER-2 (Human epidermal growth factor receptor 2) • MSI (Microsatellite instability)
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    MSI-H/dMMR
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    paclitaxel • batiraxcept (AVB-500)
    1year
    AVB-S6-500 and Durvalumab in Treating Patients With Platinum-Resistant or Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (clinicaltrials.gov)
    P1/2, N=12, Active, not recruiting, M.D. Anderson Cancer Center | Trial completion date: Aug 2024 --> Aug 2025
    Trial completion date • Combination therapy
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    Imfinzi (durvalumab) • batiraxcept (AVB-500)
    over1year
    GAS6-AS1 drives bladder cancer progression by increasing MMP7 expression in a ceRNA- and RBP-dependent manner. (PubMed, Transl Oncol)
    To sum up, GAS6-AS1 promotes UBC progression through two distinct axes: the GAS6-AS1/miR-367-3p/MMP7 axis and the GAS6-AS1/PRC1/APC/Wnt/MMP7 axis, respectively. As a potential biomarker for UBC, GAS6-AS1 holds promising prospects for the diagnosis, treatment, and prognosis of UBC.
    Journal
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    GAS6 (Growth arrest specific 6) • MMP7 (Matrix metallopeptidase 7)
    over1year
    Could Gas6/TAM Axis Provide Valuable Insights into the Pathogenesis of Systemic Sclerosis? (PubMed, Curr Issues Mol Biol)
    In the present manuscript, we review the current evidence regarding SSc pathogenesis and the role of the Gas6/TAM system in several human diseases, suggesting its likely contribution in SSc and highlighting areas where further research is necessary to fully comprehend the role of TAM receptors in this condition. Indeed, understanding the involvement of TAM receptors in SSc, which is currently unknown, could provide valuable insights for novel potential therapeutic targets.
    Review • Journal
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    AXL (AXL Receptor Tyrosine Kinase) • MERTK (MER Proto-Oncogene, Tyrosine Kinase) • GAS6 (Growth arrest specific 6)