Gastrointestinal Stromal Tumor

P2, N=24, Recruiting, Dana-Farber Cancer Institute | Not yet recruiting --> Recruiting

Surgical resection is the standard treatment for localized GIST. Imatinib is the first-line prescribed treatment, with particular attention to potentially life-threatening adverse effects.

Postoperatively, the patient received only 1 year of adjuvant imatinib (400 mg/day) and remained disease-free for the subsequent 14 years, until liver lesions were incidentally identified during a routine physical examination...This case is clinically distinctive owing to its ultra-long recurrence interval and synchronous bifocal hepatic metastasis, thereby offering valuable insights into the long-term natural course of GISTs in the setting of inadequate adjuvant tyrosine kinase inhibitor (TKI) therapy. Furthermore, it underscores the necessity of long-term postoperative surveillance for patients with GIST and highlights the potential role of comprehensive genetic testing in guiding individualized treatment decisions.

P2, N=46, Recruiting, Kumquat Biosciences Inc. | Not yet recruiting --> Recruiting

Accordingly, combination approaches integrating regorafenib with targeted agents, immune checkpoint inhibitors (ICIs), metabolic modulators, or emerging therapeutic platforms are discussed. Overall, this review provides a systems-level understanding of regorafenib resistance and highlights the importance of mechanism-guided combination therapies and biomarker-driven strategies to improve clinical outcomes.

P=N/A, N=96, Recruiting, Peking University People's Hospital | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Jun 2025 --> Jun 2026

Twenty-eight of 57 tumors (49%) showed aberrant retained staining, divided into 4 observable staining patterns: fine granular staining/blush (9/28 abnormally staining tumors), focal retention (15/28), retained staining weaker than internal control (2/28), and retained staining either equal to internal control or without internal control present (2/28). We recognize the clinical utility of SDHB IHC as an affordable, but nuanced, method for screening for SDHx pathogenic or likely pathogenic variants and recommend subsequent genetic testing for any amount of abnormally lost staining.

A comprehensive evaluation that incorporates clinical history, advanced imaging modalities-including magnetic resonance imaging and ^99mTc-labeled heat-damaged red blood cell scintigraphy-as well as multidisciplinary consultation, can enhance diagnostic accuracy and help prevent overtreatment. Current evidence indicates that asymptomatic splenosis does not necessitate surgical intervention, and precise preoperative recognition is crucial for optimizing patient management.

P2, N=322, Recruiting, Merck Sharp & Dohme LLC | N=170 --> 322

TMB appears significantly associated with aggressive clinicopathological features in GIST and serves as an independent prognostic marker. These findings suggest that TMB may hold potential for stratifying GIST patients who may require closer follow-up and more frequent surveillance.

This case report highlights the importance and seriousness of GIST even when it falls in the low-risk category. In this case, GISTs presented with fatal upper gastrointestinal hemorrhage encountered during medico-legal autopsy in a case of sudden death.

P1, N=100, Recruiting, Ascentage Pharma Group Inc. | Trial completion date: Dec 2026 --> Dec 2028 | Trial primary completion date: Dec 2025 --> Dec 2027