P4, N=42, Completed, Emory University | Recruiting --> Completed

P3, N=28, Completed, Immune Oncology Research Institute | Recruiting --> Completed | N=40 --> 28

P=N/A, N=20, Recruiting, Ain Shams University

He received intensive multimodal immunotherapy, including high-dose methylprednisolone, intravenous immunoglobulin, plasma exchange, and rituximab. This is the first report of a seizure-free, triple-positive autoimmune encephalitis subtype presenting with prominent cognitive impairment, thereby expanding the clinical spectrum of recently described overlapping autoimmune encephalitis syndromes. The low titer and rapid seroreversion of mGluR5 antibodies suggest a possible bystander phenomenon secondary to blood-brain barrier disruption.

P=N/A, N=60, Completed, Indonesia University | Recruiting --> Completed

P4, N=212, Recruiting, University Hospital, Strasbourg, France | Not yet recruiting --> Recruiting

These results indicate that BoNT/A effectively alleviates inflammatory and vascular responses in a rosacea mouse model, highlighting its potential as a promising preventive approach for rosacea.

P2, N=120, Recruiting, University of Utah | Trial completion date: Sep 2027 --> Mar 2028 | Trial primary completion date: May 2026 --> Dec 2026

P=N/A, N=22, Completed, Future University in Egypt

She was treated with a methylprednisolone taper, budesonide and infliximab, resulting in resolution of symptoms. In this case, colitis was successfully managed with corticosteroids and infliximab, allowing for safe re-challenge at a reduced dose. This case highlights the importance of recognizing and managing rare toxicities associated with antibody-drug conjugates to optimize their safe use in ovarian cancer treatment.

Lung mesenchymal stem cells (MSCs; platelet-derived growth factor receptor α+ CD31- CD45- CD326- cells) were isolated and differentiated into myofibroblasts by culturing them with 15% fetal bovine serum (FBS) for 6 d. In asthmatic lungs, α-SMA+ myofibroblasts showed increased Bcl-xL expression, which was unaffected by dexamethasone (DEX) treatment. However, co-treatment with the Bcl-xL inhibitor navitoclax significantly restored steroid sensitivity...These findings indicate that Bcl-xL-expressing myofibroblasts contribute to the development of glucocorticoid resistance in fibrotic lungs in severe asthma. Targeting Bcl-xL may provide a novel therapeutic strategy to restore steroid responsiveness in severe asthma.

The patient was initiated on comprehensive hormone replacement (including hydrocortisone, levothyroxine, testosterone, and GH) and supportive care, with complete resolution of ascites at the 2-month follow-up. We conclude that severe GH deficiency, acting in synergy with other hormonal deficits, likely served as the critical driver for NAFLD progression to cirrhosis. This report underscores the necessity of comprehensive, lifelong endocrine management and metabolic monitoring for craniopharyngioma survivors to prevent irreversible organ damage.