^
    3d
    A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial) (clinicaltrials.gov)
    P3, N=56, Active, not recruiting, Debiopharm International SA | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    triptorelin
    4d
    POP-ELA: A Short-term Preoperative, Evaluating Activity and Safety of Elacestrant Monotherapy as Compared to Elacestrant + Ovarian Function Suppression (LHRH Agonist) in Premenopausal Patients With Stage I-II ER+/HER2- Breast Cancer (clinicaltrials.gov)
    P2, N=140, Recruiting, Gustave Roussy, Cancer Campus, Grand Paris | Not yet recruiting --> Recruiting
    Enrollment open
    |
    ER positive
    |
    Orserdu (elacestrant) • leuprolide acetate for depot suspension
    9d
    A Study to Assess the Bioequivalence of Follitropin Alfa Solution in Pen and Follitropin Alfa Powder in Vial in Healthy Downregulated Male Participants (clinicaltrials.gov)
    P1, N=66, Recruiting, EMD Serono Research & Development Institute, Inc. | N=36 --> 66
    Enrollment change
    |
    goserelin acetate
    22d
    Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial (clinicaltrials.gov)
    P2, N=75, Recruiting, University of Michigan Rogel Cancer Center | Not yet recruiting --> Recruiting
    Enrollment open
    |
    goserelin acetate • leuprolide acetate for depot suspension
    24d
    Testing the Anti-cancer Drug Darolutamide in Patients With Testosterone-Driven Salivary Gland Cancers (clinicaltrials.gov)
    P2, N=21, Active, not recruiting, National Cancer Institute (NCI) | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Eligard (leuprolide acetate) • Nubeqa (darolutamide) • Viadur (leuprorelin implant)
    1m
    A real-world observational study on the trends of PSA and testosterone changes in patients with metastatic hormone-sensitive prostate cancer (mHSPC) after treatment with goserelin microspheres combined with novel hormonal agents (NHA). (ChiCTR2500109081)
    P2, N=60, Not yet recruiting, Beijing Cancer Hospital; Beijing Cancer Hospital
    New P2 trial • Real-world evidence
    |
    goserelin acetate
    2ms
    RTOG 0815: Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer (clinicaltrials.gov)
    P3, N=1538, Completed, Radiation Therapy Oncology Group | Active, not recruiting --> Completed
    Trial completion
    |
    bicalutamide • triptorelin • goserelin acetate • flutamide • Firmagon (degarelix) • leuprolide acetate for depot suspension • Suprefact (buserelin acetate)
    2ms
    Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer (clinicaltrials.gov)
    P3, N=239, Completed, Radiation Therapy Oncology Group | Active, not recruiting --> Completed | Trial completion date: Jun 2029 --> Sep 2025
    Trial completion • Trial completion date
    |
    bicalutamide • triptorelin • goserelin acetate • flutamide • leuprolide acetate for depot suspension • orteronel (TAK 700) • Suprefact (buserelin acetate)
    2ms
    EVANGELINE: (Z)-Endoxifen for the Treatment of Premenopausal Women With ER+/HER2- Breast Cancer (clinicaltrials.gov)
    P2, N=87, Recruiting, Atossa Therapeutics, Inc. | N=214 --> 87 | Trial completion date: Sep 2026 --> Apr 2027 | Trial primary completion date: Feb 2026 --> Nov 2026
    Enrollment change • Trial completion date • Trial primary completion date
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)
    |
    HER-2 negative
    |
    goserelin acetate
    2ms
    Specified Drug-Use Survey of Leuprorelin Acetate Injection Kit 11.25 mg "All-Case Investigation: Spinal and Bulbar Muscular Atrophy (SBMA)" (clinicaltrials.gov)
    P=N/A, N=1890, Recruiting, Takeda | N=300 --> 1890 | Trial completion date: Aug 2025 --> Apr 2026 | Trial primary completion date: Aug 2025 --> Apr 2026
    Enrollment change • Trial completion date • Trial primary completion date
    |
    AR (Androgen receptor)
    |
    leuprolide acetate for depot suspension
    2ms
    GenSci093-301: Safety, Efficacy and Pharmacokinetic Behavior of Leuprolide Injectable Emulsion for Premenopausal Breast Cancer Subjects. (clinicaltrials.gov)
    P3, N=211, Active, not recruiting, Changchun GeneScience Pharmaceutical Co., Ltd. | Not yet recruiting --> Active, not recruiting
    Enrollment closed
    |
    tamoxifen • leuprolide acetate for depot suspension
    2ms
    Oesophageal metastasis of prostate cancer: a case report. (PubMed, Discov Oncol)
    Oesophageal metastasis of prostate cancer is extremely rare and typically indicates advanced disease with a poor prognosis. The clinical manifestations are nonspecific and often lead to misdiagnosis. A definitive diagnosis relies on histopathology and immunohistochemical markers, such as PSA and P504S. Clinicians should maintain a high index of suspicion for metastatic prostate cancer in cases of unexplained oesophageal lesions. We hope that this case will increase clinicians' awareness of metastatic oesophageal cancer.
    Journal
    |
    AR (Androgen receptor) • CEACAM5 (CEA Cell Adhesion Molecule 5) • CA 19-9 (Cancer antigen 19-9)
    |
    goserelin acetate