P1, N=10, Active, not recruiting, Massachusetts General Hospital | Trial completion date: Dec 2025 --> Dec 2027 | Trial primary completion date: Jun 2025 --> Nov 2026

P1, N=34, Not yet recruiting, Massachusetts General Hospital | Initiation date: Jun 2025 --> Jan 2026 | Trial primary completion date: Jun 2026 --> Dec 2026

Our results demonstrated that Znhit1 ameliorated hyperalgesia and inhibited inflammatory response by suppressing the activation of NLRP3 inflammasome.

We also evaluated the effect of betamethasone on CGRP mRNA stability and release from the mouse TG, as well as on mouse spontaneous or nitroglycerin-induced cephalic allodynia.ResultsWe report that dexamethasone triggered transcriptional activation of the rat and human CGRP gene, also increasing transcript levels of RAMP1 but not of CLR in cultured cells. Of note, although a 13-fold increase of the CGRP releasable pool occurred in the TG of betamethasone-treated mice, the animals were not sensitized to cephalic allodynia.ConclusionsIn keeping with the emerging immunosuppressing effects of CGRP, corticosteroids increase its expression in rat and human cell lines, as well as in rodent TG. Evidence that a substantial increase of releasable CGRP in the TG does not reduce orofacial pain thresholds suggests that basal release of endogenous CGRP differs from its exogenous administration in terms of trigeminal afferent sensitization.

P=N/A, N=104, Not yet recruiting, Ordos Central Hospital; Ordos Central Hospital

P=N/A, N=818, Not yet recruiting, Beijing Luhe Hospital, Capital Medical University; Beijing Luhe Hospital, Capital Medical University

These results indicate that riociguat exerts protection of the kidneys from CP-caused kidney damage by antioxidation and anti-inflammation. Riociguat may have potential as an adjunct therapy to mitigate CP-associated nephrotoxicity.

On day 8, rat migraine models were established by subcutaneous injection of nitroglycerin...Warm needle acupuncture reduced ET-1 protein levels and promoted the expression of neurotransmitters, such as 5-hydroxytryptamine, in migraine rat model animals. In addition, needle warming acupuncture decreased IL-6, TNF-α, and CGRP levels in the brain stem of the migraine group, which may explain its mechanism of action in treating migraine.

P=N/A, N=20, Completed, Mansoura University

P4, N=18, Completed, Bayer | Active, not recruiting --> Completed

P2, N=120, Active, not recruiting, Merck Sharp & Dohme LLC | Recruiting --> Active, not recruiting

P=N/A, N=100, Not yet recruiting, Qilu Hospital of Shandong University