This study evaluated the effect of this complex on apoptosis induction in MCF7 cells via the extrinsic apoptotic pathway, revealing increased expression of FADD, CASP8, and p53 genes. These findings highlight a synergistic relationship between anti-angiogenic and pro-apoptotic mechanisms, offering promising avenues for future breast cancer therapies.

1 month ago

Journal

FADD (Fas associated via death domain) • CASP8 (Caspase 8)

GZ402663

7ms

In vivo inhibition of angiogenesis by htsFLT01/MiRGD nano complex. (PubMed, Transl Oncol)

Beyond its anti-angiogenic effects, the treatment also induces apoptosis and inhibits tumor cell proliferation, reinforcing its role as a promising targeted therapy for angiogenesis-dependent malignancies. These results underscore the potential of htsFLT01/MiRGD in cancer treatment and pave the way for future clinical applications in anti-angiogenic therapies.

7 months ago

Preclinical • Journal

CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)

GZ402663

over4years

sFLT01 modulates invasion and metastasis in prostate cancer DU145 cells by inhibition of VEGF/GRP78/MMP2&9 axis. (PubMed, BMC Mol Cell Biol)

Overall, these data indicated that the inhibitory impact of sFLT01 on cancer cells growth and invasiveness could be mediated through the modulation of VEGF/GRP78/MMP2&9 axis and activation of TIMPs.

over 4 years ago

Journal

MMP2 (Matrix metallopeptidase 2) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • MMP9 (Matrix metallopeptidase 9)

KIM1 expression • TIMP1 expression • MMP9 elevation

GZ402663