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    BIOMARKER:

    HCK overexpression

    i
    Other names: HCK, HCK Proto-Oncogene, Src Family Tyrosine Kinase, Hemopoietic Cell Kinase, Tyrosine-Protein Kinase HCK, Hematopoietic Cell Kinase, P59-HCK/P60-HCK, P59Hck, P61Hck, JTK9
    Entrez ID:
    3055
    Related biomarkers:
    Others
    Associations

    News

    Trials
    over2years
    Clinicopathological value of hematopoietic cell kinase overexpression in laryngeal squamous cell carcinoma tissues. (PubMed, Pathol Res Pract)
    In conclusion, HCK was upregulated in LSCC tissues and could be utilized as a risk predictor. HCK may promote the development of LSCC by disturbing immune signaling pathways.
    Journal • IO biomarker
    |
    HCK (HCK Proto-Oncogene)
    |
    HCK overexpression
    4years
    A New Role for the SRC Family Member HCK As a Driver of BCR/SYK Signaling in MYD88 Mutated Lymphomas (ASH 2021)
    Consistent with these observations, treatment of primary MYD88 mutated WM LPCs cells with either A419259 or KIN-8194 also showed marked reduction in both p-HCK and p-SYK expression by PhosFlow analysis. Taken together, our findings show that SYK is activated by HCK in MYD88 Mut B-cell lymphomas cells; broaden the pro-survival signaling generated by aberrant HCK expression in response to MYD88 Mut ; and help further establish HCK as an important therapeutic target in MYD88 Mut B-cell lymphomas.
    IO biomarker
    |
    MYD88 (MYD88 Innate Immune Signal Transduction Adaptor) • CD19 (CD19 Molecule) • LYN (LYN Proto-Oncogene Src Family Tyrosine Kinase) • SYK (Spleen tyrosine kinase) • HCK (HCK Proto-Oncogene) • IRAK4 (Interleukin 1 Receptor Associated Kinase 4)
    |
    MYD88 mutation • HCK overexpression
    |
    KIN-8194
    over4years
    Hematopoietic cell kinase enhances osteosarcoma development via the MEK/ERK pathway. (PubMed, J Cell Mol Med)
    Furthermore, HCK downregulation decreased the tumour volume and weight in mice transplanted with OS cells. In conclusion, HCK plays a crucial role in OS tumorigenesis, progression and metastasis via the MEK/ERK pathway, suggesting that HCK is a potential target for developing treatments for OS.
    Journal
    |
    CDH1 (Cadherin 1) • HCK (HCK Proto-Oncogene)
    |
    HCK overexpression