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    DRUG CLASS:

    HER2 dimerization inhibitor

    Related drugs:
    1d
    Optimize Neoadjuvant Therapy in HER2-Positive Early-Stage Breast Cancer (clinicaltrials.gov)
    P2, N=50, Recruiting, Rutgers, The State University of New Jersey | Not yet recruiting --> Recruiting
    Enrollment open • Biomarker assay • Circulating tumor DNA
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
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    HER-2 positive
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    Herceptin (trastuzumab) • carboplatin • docetaxel • Perjeta (pertuzumab)
    1d
    Real-World Study of First-Line Treatment with Trastuzumab Biosimilar and Pertuzumab Biosimilar Combined with Chemotherapy in Patients with HER2-Positive Breast Cancer (ChiCTR2600121627)
    P=N/A, N=1500, Recruiting, The Second Qilu Hospital of Shandong University; The Second Qilu Hospital of Shandong University
    New trial • Real-world evidence
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    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 amplification
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    Perjeta (pertuzumab)
    1d
    A single-arm, phase II, exploratory study of neoadjuvant treatment with Kudosil combined with Culmerciclib and dual-targeted therapy of trastuzumab and pertuzumab in HR+, HER2+ breast cancer (ChiCTR2600121242)
    P2, N=28, Recruiting, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital); The First Affiliated Hospital of Nanjing Medical U
    New P2 trial
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
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    HER-2 positive • ER positive
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    Herceptin (trastuzumab) • Perjeta (pertuzumab) • letrozole • Saitanxin (culmerciclib)
    1d
    Trastuzumab and pertuzumab in combination with eribulin mesylate as neoadjuvant therapy for early or locally advanced HER2-positive breast cancer: a prospective, single-arm, phase II clinical trial (ChiCTR2600120346)
    P4, N=40, Recruiting, The First Hospital of Jilin University; The First Hospital of Jilin University
    New P4 trial
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    HER-2 positive • HER-2 amplification • HER-2 expression
    |
    Herceptin (trastuzumab) • Perjeta (pertuzumab) • Halaven (eribulin mesylate)
    2d
    A Prospective, Multicenter, Single-Arm Clinical Study of Atezolizumab Combined with SHR-A1811and Pertuzumab in the Neoadjuvant Treatment of HER2-Positive Breast Cancer (ChiCTR2600118900)
    P2, N=50, The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University
    New P2 trial
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive
    |
    Tecentriq (atezolizumab) • Perjeta (pertuzumab) • trastuzumab rezetecan (SHR-A1811)
    2d
    A Randomized, Open-Label Trial of Trastuzumab Combined with Pyrotinib and Taxanes (THPy) versus Trastuzumab Combined with Pertuzumab and Taxanes (THP) as First‑Line Treatment for Advanced HER2‑Positive Breast Cancer (ChiCTR2500101511)
    P4, N=568, Recruiting, Anhui Provincial Cancer Hospital; Anhui Provincial Cancer Hospital | Not yet recruiting --> Recruiting
    Enrollment open
    |
    HER-2 (Human epidermal growth factor receptor 2)
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    HER-2 positive
    |
    Herceptin (trastuzumab) • Perjeta (pertuzumab) • Irene (pyrotinib)
    3d
    PERTUREAL: Real-world Bicohort Observational Study of a Pertuzumab Biosimilar in the Treatment of Breast Cancer: in the Neoadjuvant Setting and in First-line Metastatic Disease (clinicaltrials.gov)
    P=N/A, N=1000, Recruiting, Société Algérienne de Formation et Recherche en Oncologie
    New trial • Real-world evidence
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    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive • HER-2 amplification
    |
    Perjeta (pertuzumab)
    4d
    A Real-World Study on the Impact of Different Adjuvant Treatment Regimens on Prognosis in Non-pCR Patients With HER2-Positive Breast Cancer After Neoadjuvant Therapy (clinicaltrials.gov)
    P=N/A, N=2000, Not yet recruiting, Hebei Medical University Fourth Hospital
    New trial • Real-world evidence
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive • HER-2 amplification
    |
    Perjeta (pertuzumab)
    4d
    Durvalumab With Trastuzumab and Pertuzumab in HER2-Enriched Breast Cancer (clinicaltrials.gov)
    P2, N=51, Active, not recruiting, The Methodist Hospital Research Institute | N=39 --> 51 | Trial completion date: Dec 2025 --> Dec 2028
    Enrollment change • Trial completion date
    |
    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    HER-2 amplification • PD-L1 negative
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    BluePrint
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    Herceptin (trastuzumab) • Imfinzi (durvalumab) • Perjeta (pertuzumab)
    8d
    Effects of Instrument-Assisted Constant-Speed Injection Versus Manual Injection on Pain From Large-Volume Subcutaneous Injection of Pertuzumab and Trastuzumab in Breast Cancer: A Randomized, Self-Controlled Study (clinicaltrials.gov)
    P=N/A, N=40, Not yet recruiting, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
    New trial
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive
    |
    Herceptin (trastuzumab) • Perjeta (pertuzumab)
    9d
    Pathological Response to Herceptin-containing Neoadjuvant Therapy in HER2 IHC2+/ISH+ and IHC3+ Early-Stage Invasive Ductal Carcinoma. (PubMed, Hum Pathol)
    Compared with IHC 3+ IDC, IHC 2+/FISH+ IDC demonstrated lower pCR rates and inferior RFS in hormone receptor-negative subset following neoadjuvant trastuzumab/ pertuzumab-containing therapy. Pathologic response correlated inversely with HER2/CEP17 ratio and HER2 copy number. Reassessment of HER2 expression with more sensitive quantitative methods, particularly in IHC 2+/FISH+ tumors, may improve therapeutic stratification.
    Journal
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HER-2 positive • HR positive • HER-2 expression • HR negative
    |
    Herceptin (trastuzumab) • Perjeta (pertuzumab)
    10d
    Optimization of Dynamic Neoadjuvant Therapy Strategies for HER2-Positive Breast Cancer Based on HER2-PET/CT Molecular Imaging (clinicaltrials.gov)
    P2, N=156, Not yet recruiting, Peking University Cancer Hospital & Institute
    New P2 trial
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    HER-2 positive • HER-2 amplification
    |
    Herceptin (trastuzumab) • carboplatin • docetaxel • Perjeta (pertuzumab) • albumin-bound paclitaxel