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    DRUG CLASS:

    IKZF3 degrader

    Related drugs:
    14d
    CFT7455-2101: A study of cemsidomide and dexamethasone in subjects with relapsed or refractory multiple myeloma (r/r MM) (2025-524181-26-00)
    P1/2, N=43, Not yet recruiting, C4 Therapeutics Inc.
    New P1/2 trial
    |
    dexamethasone • cemsidomide (CFT7455)
    3ms
    CFT7455-1101: Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma (clinicaltrials.gov)
    P1, N=224, Active, not recruiting, C4 Therapeutics, Inc. | Trial completion date: Mar 2026 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Sep 2026
    Trial completion date • Trial primary completion date
    |
    dexamethasone • cemsidomide (CFT7455)
    3ms
    NX-2127-001: A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies (clinicaltrials.gov)
    P1, N=248, Recruiting, Nurix Therapeutics, Inc. | Trial completion date: Dec 2026 --> May 2027 | Trial primary completion date: Dec 2025 --> May 2026
    Trial completion date • Trial primary completion date • First-in-human
    |
    CD4 (CD4 Molecule)
    |
    zelebrudomide (NX-2127)
    4ms
    A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects (clinicaltrials.gov)
    P1, N=60, Recruiting, C4 Therapeutics, Inc. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    Elrexfio (elranatamab-bcmm) • cemsidomide (CFT7455)
    5ms
    MOMENTUM: A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=100, Recruiting, C4 Therapeutics, Inc. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    dexamethasone • cemsidomide (CFT7455)
    6ms
    MOMENTUM: A Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=100, Not yet recruiting, C4 Therapeutics, Inc.
    New P2 trial
    |
    dexamethasone • cemsidomide (CFT7455)
    6ms
    A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects (clinicaltrials.gov)
    P1, N=60, Not yet recruiting, C4 Therapeutics, Inc.
    New P1 trial
    |
    Elrexfio (elranatamab-bcmm) • cemsidomide (CFT7455)
    9ms
    CFT7455-1101: Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma (clinicaltrials.gov)
    P1, N=224, Active, not recruiting, C4 Therapeutics, Inc. | Trial completion date: Dec 2025 --> Mar 2026 | Trial primary completion date: Sep 2025 --> Dec 2025 | Recruiting --> Active, not recruiting | Phase classification: P1/2 --> P1
    Enrollment closed • Phase classification • Trial completion date • Trial primary completion date
    |
    TNFRSF8 (TNF Receptor Superfamily Member 8)
    |
    dexamethasone • cemsidomide (CFT7455)
    over1year
    Evaluate the Safety, Tolerability, and Efficacy of ICP-490 in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma (clinicaltrials.gov)
    P1/2, N=68, Not yet recruiting, Beijing InnoCare Pharma Tech Co., Ltd.
    New P1/2 trial
    over1year
    Safety, PK/PD, and Clinical Activity of KT-413 in Adult Patients with Relapsed or Refractory B-cell NHL (clinicaltrials.gov)
    P1, N=7, Completed, Kymera Therapeutics, Inc. | Suspended --> Completed | N=80 --> 7
    Trial completion • Enrollment change
    |
    KT-413
    almost2years
    CFT7455-1101: Study to Assess the Safety and Tolerability of CFT7455 in Relapsed/Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma (clinicaltrials.gov)
    P1/2, N=224, Recruiting, C4 Therapeutics, Inc. | N=158 --> 224
    Enrollment change
    |
    TNFRSF8 (TNF Receptor Superfamily Member 8)
    |
    dexamethasone • cemsidomide (CFT7455)
    almost2years
    NX-2127-001: A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies (clinicaltrials.gov)
    P1, N=266, Recruiting, Nurix Therapeutics, Inc. | Active, not recruiting --> Recruiting | N=160 --> 266 | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2024 --> Dec 2025
    Enrollment open • Enrollment change • Trial completion date • Trial primary completion date
    |
    TP53 (Tumor protein P53) • CD4 (CD4 Molecule)
    |
    zelebrudomide (NX-2127)