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    DRUG CLASS:

    IL-12 modulator

    Related drugs:
    1m
    This is an Open Label, Two-part, Multicenter, Phase I Trial to Investigate the Safety, Tolerability, and PK of KGX101 Monotherapy and Combination Therapy With Envafolimab in Patients With Advanced or Metastatic Solid Tumors. (clinicaltrials.gov)
    P1, N=54, Active, not recruiting, Kangabio AUSTRALIA LTD PTY | Trial completion date: May 2026 --> May 2028
    Trial completion date • First-in-human
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    PD-L1 (Programmed death ligand 1)
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    PD-L1 expression
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    Enweida (envafolimab)
    4ms
    This is a Multi-Center Study of IBI3026 in Participants With Locally Advanced, Unresectable or Metastatic Solid Tumors (clinicaltrials.gov)
    P1, N=300, Recruiting, Innovent Biologics Technology Limited (Shanghai R&D Center) | Not yet recruiting --> Recruiting
    Enrollment open
    5ms
    This is a Multi-Center Study of IBI3026 in Participants With Locally Advanced, Unresectable or Metastatic Solid Tumors (clinicaltrials.gov)
    P1, N=300, Not yet recruiting, Innovent Biologics Technology Limited (Shanghai R&D Center)
    New P1 trial
    6ms
    A Phase I Study to Investigate the Safety and Tolerability of KGX101 Monotherapy and Combination Therapy With Envafolimab in Advanced or Metastatic Solid Tumor Patients (clinicaltrials.gov)
    P1, N=57, Recruiting, Kangabio AUSTRALIA LTD PTY
    New P1 trial
    |
    Enweida (envafolimab)
    over1year
    This is an Open Label, Two-part, Multicenter, Phase I Trial to Investigate the Safety, Tolerability, and PK of KGX101 Monotherapy and Combination Therapy with Envafolimab in Patients with Advanced or Metastatic Solid Tumors. (clinicaltrials.gov)
    P1, N=54, Active, not recruiting, Kangabio AUSTRALIA LTD PTY | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    Enweida (envafolimab)
    over1year
    A Study to Learn About PF-07921585 Alone or With Other Anti-cancer Medicines in People With Cancer (clinicaltrials.gov)
    P1, N=190, Recruiting, Pfizer | Not yet recruiting --> Recruiting
    Enrollment open • Combination therapy • Metastases
    |
    Zumrad (sasanlimab)
    almost2years
    This is an Open Label, Two-part, Multicenter, Phase I Trial to Investigate the Safety, Tolerability, and PK of KGX101 Monotherapy and Combination Therapy With Envafolimab in Patients With Advanced or Metastatic Solid Tumors. (clinicaltrials.gov)
    P1, N=54, Recruiting, Kangabio AUSTRALIA LTD PTY | Not yet recruiting --> Recruiting | N=27 --> 54 | Trial completion date: Sep 2026 --> May 2026 | Trial primary completion date: Jan 2026 --> May 2026
    Enrollment open • Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    Enweida (envafolimab)
    almost2years
    Phase Ⅰ/Ⅱ Clinical Study to Evaluate ABO2011 in Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=218, Recruiting, Suzhou Abogen Biosciences Co., Ltd. | N=160 --> 218 | Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Dec 2025 --> Dec 2026
    Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    Loqtorzi (toripalimab-tpzi) • ABO2011
    2years
    Phase Ⅰ/Ⅱ Clinical Study to Evaluate ABO2011 Monotherapy in Advanced Solid Tumors (clinicaltrials.gov)
    P1/2, N=160, Recruiting, Suzhou Abogen Biosciences Co., Ltd. | Enrolling by invitation --> Recruiting | Phase classification: P1 --> P1/2 | N=40 --> 160 | Trial completion date: Nov 2025 --> Dec 2026 | Trial primary completion date: May 2025 --> Dec 2025
    Enrollment status • Phase classification • Enrollment change • Trial completion date • Trial primary completion date • Metastases
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    ABO2011
    over2years
    Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence. (PubMed, Acta Pharm Sin B)
    Mechanistically, CARG-2020 potently activates Th1 immune mechanisms and inhibits expression of genes related to T cell exhaustion and cancer-promoting inflammation. The ability of CARG-2020 to prevent tumor recurrence and to provide survival benefit makes it a promising candidate for its development for human cancer immunotherapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    IL17A (Interleukin 17A) • IL17RA (Interleukin 17 Receptor A)
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    CARG-2020
    over2years
    A Study to Evaluate ABO2011 Monotherapy in Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=40, Enrolling by invitation, Suzhou Abogen Biosciences Co., Ltd. | Recruiting --> Enrolling by invitation
    Enrollment status • Metastases
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    ABO2011
    over3years
    RPTR-168 in Patients With Human Papillomavirus Strain 16 (HPV-16) E6/E7 Positive Tumors and Melanoma (clinicaltrials.gov)
    P1/2, N=7, Terminated, Repertoire Immune Medicines | Trial completion date: May 2024 --> Oct 2022 | Active, not recruiting --> Terminated | Trial primary completion date: May 2024 --> Sep 2022; Development program terminated
    Trial completion date • Trial termination • Trial primary completion date
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    PD-L1 (Programmed death ligand 1) • PRAME (Preferentially Expressed Antigen In Melanoma)
    |
    PD-1 expression
    |
    RPTR-168