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    DRUG CLASS:

    IL-2 modulator

    Related drugs:
    23d
    A Study to Investigate the Efficacy and Safety of SAR444336 in Adults With Microscopic Colitis in Clinical Remission (clinicaltrials.gov)
    P2, N=54, Recruiting, Sanofi | Not yet recruiting --> Recruiting
    Enrollment open
    2ms
    ALSTARS: Study of COYA 302 for the Treatment of ALS (clinicaltrials.gov)
    P2, N=120, Recruiting, Coya Therapeutics | Not yet recruiting --> Recruiting
    Enrollment open
    3ms
    ALSTARS: Study of COYA 302 for the Treatment of ALS (clinicaltrials.gov)
    P2, N=120, Not yet recruiting, Coya Therapeutics
    New P2 trial
    3ms
    A Study to Investigate the Efficacy and Safety of SAR444336 in Adults With Microscopic Colitis in Clinical Remission (clinicaltrials.gov)
    P2, N=54, Not yet recruiting, Sanofi
    New P2 trial
    6ms
    DEKA-1: Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors (clinicaltrials.gov)
    P1, N=39, Active, not recruiting, DEKA Biosciences | Recruiting --> Active, not recruiting | N=60 --> 39 | Trial primary completion date: Mar 2025 --> Jul 2025
    Enrollment closed • Enrollment change • Trial primary completion date • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • IL2 (Interleukin 2) • IL10 (Interleukin 10)
    |
    EGFR expression
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • carboplatin • paclitaxel • 5-fluorouracil • capecitabine • oxaliplatin • DK210 (EGFR)
    7ms
    The effect of an intravenous analgesic pump with esketamine on postoperative pain and postpartum depression in women with cesarean section. (PubMed, Am J Transl Res)
    Esketamine-based postoperative analgesia for cesarean section effectively reduces perioperative pain, alleviates postpartum depression, mitigates inflammatory and stress responses, and has certain neuroprotective effects. Its safety profile supports its potential for broader clinical use.
    Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • BDNF (Brain Derived Neurotrophic Factor)
    9ms
    Xiapyrroles A-F: N-Alkylpyrrole Alkaloids from the Marine-Derived Actinomycete Streptomyces xiamenensis 1310KO-148. (PubMed, J Nat Prod)
    However, 1 dose-dependently suppressed the LPS-induced production of NO (IC50 = 29.5 μM) and interleukin-6 (IL-6) (IC50 = 10.9 μM). Compound 1 exhibited no potential cytotoxicity against six solid cancer cell lines and eight blood cancer cell lines at a concentration of 30 μM.
    Journal
    |
    IL6 (Interleukin 6)
    11ms
    DEKA-1: Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors (clinicaltrials.gov)
    P1, N=60, Recruiting, DEKA Biosciences | Trial completion date: Feb 2025 --> Oct 2025 | Trial primary completion date: Sep 2024 --> Mar 2025
    Trial completion date • Trial primary completion date • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • IL2 (Interleukin 2) • IL10 (Interleukin 10)
    |
    EGFR expression
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab) • carboplatin • paclitaxel • 5-fluorouracil • capecitabine • oxaliplatin • DK210 (EGFR)
    1year
    A Single-Center, Phase II, Randomized, Controlled Clinical Study Evaluating Injectable Thymofaxine (Nitazan) in Combination with Injectable Human Interleukin-2 (Deruson) for the Treatment of Lymphopenia in Patients with Malignant Hematologic Neoplasms (ChiCTR2400090033)
    P2, N=45, Not yet recruiting, The First Affiliated Hospital of Xiamen University; The First Affiliated Hospital of Xiamen University
    New P2 trial • Combination therapy
    |
    CD4 (CD4 Molecule)
    1year
    First-in-human Trial of EGL-001 in Patients with Selected Advanced And/or Metastatic Solid Tumors (clinicaltrials.gov)
    P1/2, N=50, Recruiting, Egle Therapeutics
    New P1/2 trial
    over1year
    Thymalfasin and Recombinant Human IL-2 Injections in Treating Lymphocytopenia for Patients With Malignant Hematological Tumors (clinicaltrials.gov)
    P2, N=50, Recruiting, The First Affiliated Hospital of Xiamen University
    New P2 trial
    |
    Zadaxin (thymalfasin)
    almost2years
    Tolerability, Pharmacokinetics and Pharmacodynamics of Ascending Single and Repeated Doses of SAR444336 in Healthy Adult Participants (clinicaltrials.gov)
    P1, N=76, Completed, Sanofi | Recruiting --> Completed
    Trial completion
    |
    CRP (C-reactive protein)