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    DRUG CLASS:

    Immunosuppressant

    Related drugs:
    2d
    Unrelated Umbilical Cord Blood Transplantation for the Treatment of Amyotrophic Lateral Sclerosis (ALS) (clinicaltrials.gov)
    P=N/A, N=8, Enrolling by invitation, Institute of Hematology & Blood Diseases Hospital, China
    New trial
    |
    CD34 (CD34 molecule)
    |
    fludarabine IV
    2d
    Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia (clinicaltrials.gov)
    P2, N=20, Recruiting, Northside Hospital, Inc. | Trial completion date: Aug 2027 --> Aug 2028 | Trial primary completion date: Aug 2026 --> Aug 2027
    Trial completion date • Trial primary completion date
    |
    HLA-B (Major Histocompatibility Complex, Class I, B)
    |
    cyclophosphamide • fludarabine IV
    7d
    U-EMPOWER: Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease (clinicaltrials.gov)
    P3, N=110, Recruiting, AbbVie | Trial primary completion date: Feb 2031 --> Jun 2027
    Trial primary completion date
    7d
    MyMy: MYREPTIC-N® or MY-REPT® in Stable Patients After Kidney Transplant Recipients (clinicaltrials.gov)
    P4, N=158, Completed, Chong Kun Dang Pharmaceutical | Recruiting --> Completed
    Trial completion
    7d
    MONTBLANC: Efficacy and Safety of Everolimus Versus Mycophenolate Mofetil in Liver Transplant Recipients. (clinicaltrials.gov)
    P4, N=150, Completed, Chong Kun Dang Pharmaceutical | Recruiting --> Completed
    Trial completion
    |
    everolimus
    7d
    A Study to Compare the Effectiveness and Safety of T1695 Versus Ciclosporin in Participants With Moderate to Severe Vernal Keratoconjunctivitis (clinicaltrials.gov)
    P2, N=120, Recruiting, Laboratoires Thea | Not yet recruiting --> Recruiting
    Enrollment open
    8d
    EPARGNE: Study to Compare the Safety and Efficacy of Sirolimus (Rapamune) to Tacrolimus (Advagraf) Associated to Mycophenolate Mofetil (CellCept) Between 12 and 36 Months After Kidney Transplantation (clinicaltrials.gov)
    P3, N=65, Terminated, University Hospital, Rouen | Completed --> Terminated; Difficulty in enrolling new patients
    Trial termination
    |
    sirolimus
    9d
    Tjalma Syndrome: A Rare Autoimmune Cause of Multisystem Serositis. (PubMed, Cureus)
    Treatment with immunosuppressants such as corticosteroids, hydroxychloroquine, and azathioprine resulted in symptomatic improvement. However, the disease course was complicated by constrictive pericarditis requiring pericardiectomy and later inflammatory arthritis requiring escalation of immunosuppression. This case highlights the importance of considering autoimmune etiologies in patients with unexplained multisystem effusions and elevated tumor markers, thereby avoiding misdiagnosis and unnecessary oncological interventions.
    Journal
    |
    MUC16 (Mucin 16, Cell Surface Associated)
    |
    hydroxychloroquine
    9d
    CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma (clinicaltrials.gov)
    P1, N=60, Recruiting, St. Jude Children's Research Hospital | Initiation date: Mar 2026 --> Jun 2026
    Trial initiation date
    |
    cyclophosphamide • melphalan • fludarabine IV • mesna • thiotepa • Neupogen (filgrastim)
    10d
    EBV-Negative Post-Lung Transplant Lymphoma Diagnosed via Paracentesis: A Case Report and Literature Review. (PubMed, Case Rep Transplant)
    Mycophenolate mofetil was discontinued, and tacrolimus levels were maintained at 6-8 ng/mL...EBV-negative PTLD is rare and often fatal. Ascitic fluid cytology can facilitate early, minimally invasive diagnosis, warranting high clinical suspicion in transplant recipients with unexplained ascites.
    Journal
    |
    CD20 (Membrane Spanning 4-Domains A1) • MME (Membrane Metalloendopeptidase)
    |
    CD20 positive
    13d
    Ex Vivo Perfusion of Gene-Edited Porcine Livers in Patients With Severe Hepatic Failure (clinicaltrials.gov)
    P1, N=1, Active, not recruiting, Xijing Hospital
    New P1 trial
    13d
    A Study Comparing Haploidentical Hematopoietic Stem Cell Transplantations (HSCTs) From Young Non-first-degree and Older First-degree Donors in Hematological Malignancies (clinicaltrials.gov)
    P3, N=232, Active, not recruiting, First Affiliated Hospital of Zhejiang University | Recruiting --> Active, not recruiting | N=176 --> 232 | Trial completion date: Dec 2025 --> Apr 2026 | Trial primary completion date: Sep 2025 --> Apr 2026
    Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date
    |
    cytarabine • cyclophosphamide • busulfan • cyclosporin A microemulsion