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    DRUG:

    uprevstobart (INCA00186)

    i
    Other names: INCA00186, INCA 0186
    Associations

    News

    Trials
    Company:
    Incyte
    Drug class:
    CD73 inhibitor
    Related drugs:
    Associations

    News

    Trials
    3ms
    Study of INCA 0186 in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=57, Terminated, Incyte Corporation | Completed --> Terminated; This was a strategic business decision. There were no safety concerns contributing to this decision.
    Trial termination
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    CD8 (cluster of differentiation 8)
    |
    Zynyz (retifanlimab-dlwr) • INCB106385 • uprevstobart (INCA00186)
    6ms
    Study of INCA 0186 in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=57, Completed, Incyte Corporation | Active, not recruiting --> Completed | Trial completion date: Jun 2025 --> Sep 2024 | Trial primary completion date: Jun 2025 --> Sep 2024
    Trial completion • Trial completion date • Trial primary completion date
    |
    CD8 (cluster of differentiation 8)
    |
    Zynyz (retifanlimab-dlwr) • INCB106385 • uprevstobart (INCA00186)
    almost2years
    Study of INCA 0186 in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=57, Active, not recruiting, Incyte Corporation | Trial completion date: Jan 2024 --> Jun 2025 | Trial primary completion date: Jan 2024 --> Jun 2025
    Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    CD8 (cluster of differentiation 8)
    |
    Zynyz (retifanlimab-dlwr) • INCB106385 • uprevstobart (INCA00186)
    over2years
    Study of INCA 0186 in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=57, Active, not recruiting, Incyte Corporation | Recruiting --> Active, not recruiting | N=210 --> 57 | Trial completion date: Feb 2025 --> Jan 2024 | Trial primary completion date: Feb 2025 --> Jan 2024
    Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date • Combination therapy • Metastases
    |
    CD8 (cluster of differentiation 8)
    |
    Zynyz (retifanlimab-dlwr) • INCB106385 • uprevstobart (INCA00186)
    3years
    Study of INCA 0186 in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=210, Recruiting, Incyte Corporation | Trial completion date: Aug 2024 --> Jan 2025 | Trial primary completion date: Aug 2024 --> Jan 2025
    Trial completion date • Trial primary completion date • Combination therapy
    |
    CD8 (cluster of differentiation 8)
    |
    Zynyz (retifanlimab-dlwr) • INCB106385 • uprevstobart (INCA00186)
    4years
    Study of INCA 0186 in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=230, Recruiting, Incyte Corporation | Not yet recruiting --> Recruiting
    Clinical • Enrollment open • Combination therapy
    |
    CD8 (cluster of differentiation 8) • CD73 (5'-Nucleotidase Ecto)
    |
    Zynyz (retifanlimab-dlwr) • INCB106385 • uprevstobart (INCA00186)
    over4years
    Study of INCA 0186 in Subjects With Advanced Solid Tumors (clinicaltrials.gov)
    P1, N=230, Not yet recruiting, Incyte Corporation
    Clinical • New P1 trial • Combination therapy
    |
    CD8 (cluster of differentiation 8) • CD73 (5'-Nucleotidase Ecto)
    |
    Zynyz (retifanlimab-dlwr) • INCB106385 • uprevstobart (INCA00186)
    over4years
    [VIRTUAL] Discovery and preclinical characterization of INCA00186, a humanized monoclonal antibody antagonist of CD73, as a cancer immunotherapy (AACR 2021)
    In summary, the data presented in this study demonstrates that INCA00186 is a potent CD73 antagonist and effectively attenuates adenosine induced immunosuppression in the tumor microenvironment. INCA00186 demonstrated anti-tumor immunity alone and, to a greater extent, in combination with the A2A/A2B adenosine receptor antagonist INCB106385.
    Preclinical • Late-breaking abstract
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    IFNG (Interferon, gamma) • CD73 (5'-Nucleotidase Ecto) • CD34 (CD34 molecule) • ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1)
    |
    INCB106385 • uprevstobart (INCA00186)