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    DRUG CLASS:

    Insulin receptor antagonist

    Related drugs:
    1m
    A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism (clinicaltrials.gov)
    P3, N=16, Recruiting, Rezolute | N=48 --> 16
    Enrollment change
    5ms
    Mining of Targeted Therapeutic Drugs for Hepatocellular Carcinoma based on Programmed Death-related Features and Construction of an Imaging Histology Diagnostic Model. (PubMed, Curr Top Med Chem)
    This study identified key genes associated with PCD in LIHC, revealed its immunoregulatory mechanism, and predicted potential target drugs, providing new ideas for precision treatment and diagnosis of hepatocellular carcinoma.
    Journal
    |
    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • CD200R1 (CD200 Receptor 1)
    |
    GSK 1838705A
    7ms
    A Phase 3 Study of Ersodetug in Patients With Tumor-Associated Hyperinsulinism (clinicaltrials.gov)
    P3, N=48, Recruiting, Rezolute | Not yet recruiting --> Recruiting
    Enrollment open
    9ms
    tHI: A Phase 3 Study of Ersodetug in Patients With Tumor-Associated Hyperinsulinism (clinicaltrials.gov)
    P3, N=48, Not yet recruiting, Rezolute
    New P3 trial
    almost2years
    sunRIZE: RZ358 Treatment for Congenital Hyperinsulinism (clinicaltrials.gov)
    P3, N=56, Recruiting, Rezolute | Not yet recruiting --> Recruiting
    Enrollment open
    almost2years
    sunRIZE: RZ358 Treatment for Congenital Hyperinsulinism (clinicaltrials.gov)
    P3, N=56, Not yet recruiting, Rezolute
    New P3 trial
    over2years
    Treatment Of Severe Refractory Hypoglycemia Due To Malignant Insulinoma With A Novel Anti-insulin Receptor Antibody (ENDO 2023)
    High-dose diazoxide, everolimus, dexamethasone, glucagon, pasireotide, or enteral feeding did not produce a response. No adverse effects have been observed. In summary, the anti-insulin receptor monoclonal antibody RZ358 effectively controlled hypoglycemia refractory to multiple other therapies, allowing restoration of normoglycemia and enabling additional successful cancer therapy.
    Late-breaking abstract
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    IR (Insulin receptor) • MEN1 (Menin 1)
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    everolimus • Signifor (pasireotide)
    over2years
    Inhibition of the epigenetically activated miR-483-5p/IGF-2 pathway results in rapid loss of meningioma tumor cell viability. (PubMed, J Neurooncol)
    Meningioma cell growth is critically dependent on autocrine miR-483/IGF-2 stimulation and the IGF-2 pathway provides a feasible meningioma treatment target.
    Journal • Tumor cell
    |
    IGF2 (Insulin-like growth factor 2) • MIR483 (MicroRNA 483)
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    Zykadia (ceritinib) • GSK 1838705A
    over4years
    IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R. (PubMed, Cell Death Dis)
    In addition, the combined treatment of ACLY inhibitor ETC-1002 and IGF1R inhibitor Linsitinib dramatically suppressed HOXA13-mediated CRC metastasis. In conclusion, HOXA13 is a prognostic biomarker in CRC patients. Targeting the IGF1-HOXA13-IGF1R positive feedback loop may provide a potential therapeutic strategy for the treatment of HOXA13-driven CRC metastasis.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • IGF1 (Insulin-like growth factor 1)
    |
    HIF1A expression
    |
    linsitinib (ASP7487)
    over4years
    [VIRTUAL] Insulin-like growth factor-2 a potential target for screening and treatment in patients with triple negative breast cancer (AACR 2021)
    This data suggest that IGF2 is a potential biological marker for breast cancer disparities and that targeting receptors of IGF2 with drugs such as BMS-754807 could provide additional treatment options in combination with current therapies, thus reducing TNBC progression and ultimately improving patient outcomes. [Funded by NIH U54 143931 Cancer Center Partnership and CBCRP]
    Clinical
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • IGF2 (Insulin-like growth factor 2) • IR (Insulin receptor)
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    BMS-754807
    almost5years
    Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer. (PubMed, Sci Rep)
    Furthermore, pharmacological inhibition of AKT phosphorylation, using MK2206, inhibited the SOX2-mediated spheroid formation of bladder cancer cells...Lastly, pharmacological inhibition of IGF1R, using linsitinib, also inhibited the SOX2-mediated spheroid formation of bladder cancer cells under low-serum stress. Our findings indicate the SOX2-IGF2 signaling affects the aggressiveness of bladder cancer cell growth. This signaling could be a promising biomarker and therapeutic target for bladder cancer intervention.
    Journal
    |
    IGF1R (Insulin-like growth factor 1 receptor) • IGF2 (Insulin-like growth factor 2) • SOX2 • POU5F1 (POU Class 5 Homeobox 1)
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    MK-2206 • linsitinib (ASP7487)