^
    5ms
    IZALCO: A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=118, Recruiting, Sanofi | Active, not recruiting --> Recruiting | N=74 --> 118 | Trial completion date: Mar 2027 --> May 2028 | Trial primary completion date: Nov 2024 --> Feb 2026
    Enrollment open • Enrollment change • Trial completion date • Trial primary completion date
    |
    carfilzomib • dexamethasone injection • isatuximab subcutaneous (SAR650984 SC)
    5ms
    CD38-CAR human NK cells in combination with ATRA enhance cytotoxicity against CD38-expressing hematologic malignancies. (PubMed, Blood Neoplasia)
    Additionally, AAVS1KO/CD38-CAR NK cells were capable of targeting CD38 without experiencing fratricide and have a similar enhanced metabolic activity via the inhibitory activity of the cis-acting isatuximab-based scFv. Finally, we report fratricide-resistant CD38-CAR NK cells with enhanced metabolism and cytotoxicity toward CD38+ hematologic malignancies, further increased by combination treatment with ATRA.
    Journal • IO biomarker
    |
    CD38 (CD38 Molecule)
    |
    isatuximab subcutaneous (SAR650984 SC)
    9ms
    SubQSA: A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=64, Recruiting, Sanofi | Not yet recruiting --> Recruiting
    Enrollment open
    |
    carfilzomib • isatuximab subcutaneous (SAR650984 SC)
    9ms
    Lenalidomide, Bortezomib and Dexamethasone Induction Therapy with Either Intravenous or Subcutaneous Isatuximab in Patients with Newly Diagnosed Multiple Myeloma (clinicaltrials.gov)
    P3, N=514, Active, not recruiting, University of Heidelberg Medical Center | Recruiting --> Active, not recruiting
    Enrollment closed • Head-to-Head
    |
    lenalidomide • bortezomib • melphalan • isatuximab subcutaneous (SAR650984 SC)
    10ms
    ELISA in Relapsed/Refractory MM (clinicaltrials.gov)
    P2, N=30, Not yet recruiting, Massachusetts General Hospital
    New P2 trial
    |
    Elrexfio (elranatamab-bcmm) • isatuximab subcutaneous (SAR650984 SC)
    11ms
    International Treatment-extension Study in Adult Participants With Multiple Myeloma and Who Have Derived Clinical Benefit From Isatuximab (clinicaltrials.gov)
    P2, N=70, Active, not recruiting, Sanofi | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    lenalidomide • Libtayo (cemiplimab-rwlc) • carfilzomib • pomalidomide • isatuximab subcutaneous (SAR650984 SC)
    1year
    Multicenter Phase 2 Study of Subcutaneous Isatuximab Plus Bortezomib, Lenalidomide and Dexamethasone in the Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma (clinicaltrials.gov)
    P=N/A, N=74, Active, not recruiting, Poitiers University Hospital | Trial primary completion date: Jul 2024 --> Jul 2026
    Trial primary completion date
    |
    lenalidomide • bortezomib • isatuximab subcutaneous (SAR650984 SC)
    over1year
    Safety, Pharmacokinetics, and Efficacy of Subcutaneous Isatuximab in Adults With Warm Autoimmune Hemolytic Anemia (wAIHA) (clinicaltrials.gov)
    P2, N=8, Terminated, Sanofi | Phase classification: P1b/2 --> P2
    Phase classification
    |
    isatuximab subcutaneous (SAR650984 SC)
    over1year
    SubQSA: A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=64, Not yet recruiting, Sanofi | Initiation date: Jun 2024 --> Nov 2024
    Trial initiation date • Combination therapy
    |
    carfilzomib • isatuximab subcutaneous (SAR650984 SC)
    over1year
    SC Versus IV Isatuximab in Combination With Pomalidomide and Dexamethasone in RRMM (clinicaltrials.gov)
    P3, N=534, Active, not recruiting, Sanofi | Recruiting --> Active, not recruiting | Trial primary completion date: May 2024 --> Nov 2024
    Enrollment closed • Trial primary completion date • Combination therapy
    |
    pomalidomide • Sarclisa (isatuximab-irfc) • isatuximab subcutaneous (SAR650984 SC)
    over1year
    A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (clinicaltrials.gov)
    P2, N=71, Active, not recruiting, Sanofi | Recruiting --> Active, not recruiting
    Enrollment closed • Combination therapy
    |
    carfilzomib • dexamethasone injection • isatuximab subcutaneous (SAR650984 SC)
    over1year
    Multicenter Phase 2 Study of Subcutaneous Isatuximab Plus Bortezomib, Lenalidomide and Dexamethasone in the Treatment of Newly Diagnosed Transplant Ineligible Multiple Myeloma (clinicaltrials.gov)
    P=N/A, N=74, Active, not recruiting, Poitiers University Hospital | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    lenalidomide • bortezomib • isatuximab subcutaneous (SAR650984 SC)