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    DRUG:

    itraconazole

    Company:
    Generic mfg.
    Drug class:
    CYP51A1 inhibitor
    Related drugs:
    1d
    A Study to Test the Effects of Itraconazole and Carbamazepine on OPC-167832 in Healthy Men and Women (clinicaltrials.gov)
    P1, N=24, Completed, Otsuka Pharmaceutical Development & Commercialization, Inc.
    New P1 trial
    |
    itraconazole
    6d
    A Phase I Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of HS-10506 in Healthy Chinese Adult Participants (clinicaltrials.gov)
    P1, N=20, Not yet recruiting, Jiangsu Hansoh Pharmaceutical Co., Ltd.
    New P1 trial
    |
    itraconazole
    8d
    A Study in Healthy Men to Test How Itraconazole Influences the Amount of BI 764198 in the Blood (clinicaltrials.gov)
    P1, N=14, Completed, Boehringer Ingelheim | Active, not recruiting --> Completed
    Trial completion
    |
    itraconazole
    10d
    Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus (clinicaltrials.gov)
    P2, N=64, Not yet recruiting, National Cancer Institute (NCI) | Trial completion date: Jan 2028 --> Feb 2030 | Trial primary completion date: Jan 2028 --> Feb 2030
    Trial completion date • Trial primary completion date
    |
    itraconazole • Tolsura (SUBA-itraconazole)
    11d
    BNT326-01: A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors (clinicaltrials.gov)
    P1/2, N=280, Recruiting, BioNTech SE
    New P1/2 trial
    |
    itraconazole • pumitamig (BNT327) • BNT326
    11d
    BNT326-01: A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors (clinicaltrials.gov)
    P1/2, N=280, Recruiting, BioNTech SE | N=172 --> 280
    Enrollment change
    |
    itraconazole • pumitamig (BNT327) • BNT326
    16d
    GLITZ: Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in CPA-ABPA Overlap Syndrome (clinicaltrials.gov)
    P=N/A, N=104, Recruiting, Post Graduate Institute of Medical Education and Research, Chandigarh | Trial completion date: Dec 2025 --> Feb 2027 | Trial primary completion date: Dec 2024 --> Jan 2027
    Trial completion date • Trial primary completion date
    |
    prednisone • itraconazole • prednisolone
    20d
    A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060 (clinicaltrials.gov)
    P1, N=25, Completed, Pfizer | Recruiting --> Completed
    Trial completion
    |
    itraconazole • atirmociclib (PF-07220060)
    25d
    Drug-drug Interaction Trial of AP31969 and Carbamazepine or Itraconazole (clinicaltrials.gov)
    P1, N=28, Not yet recruiting, Acesion Pharma | Trial completion date: Sep 2026 --> May 2026
    Trial completion date
    |
    itraconazole
    28d
    Сlinical Study Aiming to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses of ZE63-0302 in Healthy Volunteers (clinicaltrials.gov)
    P1, N=82, Completed, Eilean Therapeutics | Recruiting --> Completed
    Trial completion • First-in-human
    |
    itraconazole
    1m
    Mechanism-guided untargeted-to-targeted lipidomics identifies phosphatidylcholine 38:4 in rat bile as an Abcb4/Mdr2 inhibition marker. (PubMed, Drug Metab Dispos)
    Multistage collision-induced dissociation/mass spectrometry3 fragmentation further confirmed the identity as arachidonyl phosphatidylcholine 18:0/20:4. Its rapid and specific decline in the presence of the Mdr2 inhibitor itraconazole offers a potential new tool for early detection of human multidrug resistance protein 3-related liver injury risk during drug development.
    Preclinical • Journal
    |
    ABCB4 (ATP Binding Cassette Subfamily B Member 4)
    |
    itraconazole
    1m
    A Study to Learn if Itraconazole Changes How the Body Processes PF-07248144 (Study Medicine) (clinicaltrials.gov)
    P1, N=12, Active, not recruiting, Pfizer | Recruiting --> Active, not recruiting
    Enrollment closed
    |
    itraconazole • prifetrastat (PF-07248144)