Kaposi Sarcoma

Moreover, our intracellular and extracellular viral titers indicate that FABP4 affects maximal infectious virion production. This study highlights the role of FABP4 and its therapeutic potential as a target that facilitates KSHV infection and pathogenesis.

Conserved hydrogen bonds, π-cation interactions, and significant hydrophobic packing at ATP-binding clefts and regulatory domains supported these interaction patterns, indicating competitive suppression of host signaling nodes taken over by HBV. Together, these results demonstrate that the components of PN possess strong multitarget binding capabilities across the PI3K/AKT, JAK-STAT, SRC-family kinase, EGFR, and SYK pathways, supporting their potential repurposing as host-directed HBV therapeutics with the ability to impede immune evasion, viral persistence, and HBV-associated oncogenic progression.

KSHV sequences from Congo samples present phylogenetic particularities but remain close to the whole genome sequences found in Sub-Saharan Africa. We were able to observe, using bioinformatics tools, only very few mutations due to APOBEC3B on KSHV genome.

Moreover, SFPQ depletion in uninfected cells induced IFN response genes, including MDA5 and ZBP1, and impaired cell growth. In summary, SFPQ binds ADAR1 and modulates its editing function, thereby preventing cellular RNAs from activating MDA5-mediated innate immune responses.

P2, N=28, Not yet recruiting, AIDS Malignancy Consortium

Moreover, we demonstrated that genetically disrupting the host H3.3 chaperone HIRA pathway by CRISPR/Cas9-mediated knockout impacted the regulation of LANA and maintenance of viral latency that was not altered in DAXX knockout cells. Collectively, these results support a role for HIRA-mediated H3.3 deposition in the regulation of KSHV latency.

P2, N=28, Recruiting, Instituto do Cancer do Estado de São Paulo | Active, not recruiting --> Recruiting

P2, N=17, Recruiting, Assistance Publique - Hôpitaux de Paris | Not yet recruiting --> Recruiting

This virus-driven EndMT contributes to vascular remodelling, chronic inflammation, aberrant angiogenesis, and the development of oncoviral-associated cardiovascular pathology and vascular tumours. The present review integrates current virological and mechanistic insights into EndMT as a hijacked host process, highlighting its role at the virus-host interface and discussing emerging antiviral and pathway-targeted strategies aimed at limiting oncovirus-mediated endothelial dysfunction.

We characterize KHDRBS3 as a major host factor that is critical for KSHV lytic replication and uncover its key role in KSHV lytic gene transcription. Our results highlight a pivotal role for the miR-31-5p/KHDRBS3 axis in modulating KSHV reactivation and provide insights into gene-expression regulation of lytic KSHV.

Bacterial cellulitis was the most common dermatological condition overall, while oral candidiasis was the most common condition in those with advanced HIV infection. Further work is needed to better characterize the profile of skin disease in PLHIV, including in larger prospective cohorts and outpatient settings.

P1, N=15, Active, not recruiting, Imperial College London | Recruiting --> Active, not recruiting | Trial completion date: Apr 2026 --> Dec 2026 | Trial primary completion date: Apr 2026 --> Jul 2026