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    DRUG:

    YTS104

    i
    Other names: YTS104, S104, LILRB4 STAR-T
    Associations

    News

    Trials
    Company:
    Beijing Qingyi Taike Pharma, BriSTAR Immunotech
    Drug class:
    ILT-3 inhibitor
    Related drugs:
    Associations

    News

    Trials
    4ms
    YTS104 Cell Injection for the Treatment of Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov)
    P1, N=12, Recruiting, Institute of Hematology & Blood Diseases Hospital, China | Not yet recruiting --> Recruiting
    Enrollment open
    |
    LILRB4 (Leukocyte Immunoglobulin Like Receptor B4)
    |
    cyclophosphamide • fludarabine IV • YTS104
    9ms
    LILRB4 STAR-T Cells in the Treatment of R/R AML/CMML (clinicaltrials.gov)
    P1, N=11, Completed, Peking University People's Hospital | Trial primary completion date: Dec 2023 --> Aug 2024 | Not yet recruiting --> Completed
    Trial completion • Trial primary completion date
    |
    LILRB4 (Leukocyte Immunoglobulin Like Receptor B4)
    |
    cyclophosphamide • fludarabine IV • YTS104
    over1year
    LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma. (PubMed, Haematologica)
    In conclusion, our study elucidates that LILRB4 is an ideal biomarker and promising immunotherapy target for high-risk MM. LILRB4-STAR-T cell immunotherapy is promising against tumor cells and immunosuppressive tumor microenvironment in MM.
    Journal • IO biomarker • Tumor cell
    |
    LILRB4 (Leukocyte Immunoglobulin Like Receptor B4)
    |
    YTS104
    over2years
    YTS104 Cell Injection for the Treatment of Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov)
    P1, N=8, Not yet recruiting, Institute of Hematology & Blood Diseases Hospital
    New P1 trial
    |
    LILRB4 (Leukocyte Immunoglobulin Like Receptor B4)
    |
    cyclophosphamide • YTS104