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    DRUG:

    Lipusu (liposomal paclitaxel)

    Associations

    News

    Trials
    Company:
    Luye Group
    Drug class:
    Tubulin inhibitor
    Related drugs:
    Associations

    News

    Trials
    2ms
    Astragalus polysaccharide-based nano-platforms loading PTX to boost chemo-immunotherapy for triple-negative breast cancer with intrinsic GLUT-targeting ability and immunoregulatory activity. (PubMed, J Nanobiotechnology)
    Compared to PTX or Lipusu® (PTX-Lipo), APS-PTX NPs increased cellular uptake by binding to high expressed glucose transporter of 4T1 cells, and synergistically enhanced cytotoxicity of PTX...In the TNBC model, APS-PTX NPs synergistically activates a potent systemic anti-tumor immunity, effectively inhibiting tumor growth and lung metastasis, and alleviating the reduction of white blood cell induced by PTX. Overall, the multifunctional nanoplatforms based on APS could overcome the harsh tumor biological barriers, and boost chemo-immunotherapy for TNBC treatment.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1)
    |
    PD-L1 expression
    |
    Lipusu (liposomal paclitaxel)
    1year
    ORIENTA: Organoid-based Functional Precision Therapy for Advanced Breast Cancer (clinicaltrials.gov)
    P2, N=252, Recruiting, Guangdong Provincial People's Hospital | Initiation date: Jan 2024 --> Sep 2024
    Trial initiation date • Metastases
    |
    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)
    |
    HR positive • HER-2 negative • ER positive + PGR positive • HER-2 negative + ER positive • HER-2 negative + HR negative
    |
    carboplatin • gemcitabine • Enhertu (fam-trastuzumab deruxtecan-nxki) • capecitabine • albumin-bound paclitaxel • cyclophosphamide • Halaven (eribulin mesylate) • pegylated liposomal doxorubicin • vinorelbine tartrate • Trodelvy (sacituzumab govitecan-hziy) • Lipusu (liposomal paclitaxel) • utidelone IV (UTD1)
    4years
    Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study. (PubMed, Cancer Commun (Lond))
    The LP regimen demonstrated similar PFS, OS, ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles. The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen.
    Clinical • Journal
    |
    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8)
    |
    gemcitabine • Lipusu (liposomal paclitaxel)