A 53-year-old man with metastatic, castration-sensitive prostate cancer (cT3bN1M1b, PSA 9.39 ng/mL, Gleason 4 + 5) underwent androgen deprivation therapy using bicalutamide and leuprorelin. After 73 cycles, chemotherapy was discontinued, and the patient has remained in remission during follow-up. This case highlights the potential efficacy of carboplatin and paclitaxel in treating poorly differentiated CRPC, suggesting the need for further investigation into platinum-based regimens for aggressive prostate cancer variants.

5 days ago

Journal

AR (Androgen receptor) • NKX3-1 (NK3 homeobox 1)

carboplatin • paclitaxel • bicalutamide • leuprolide acetate for depot suspension

Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide. (PubMed, Case Rep Oncol Med)

A 75-year-old man with mHSPC was treated with Apa and leuprorelin. Apa induced CYP3A4 via the PXR pathway, leading to a sustained DDI with CsA. Careful monitoring is necessary when Apa is coadministered with CYP3A4 substrates.

9 days ago

Journal

CYP3A4 (Cytochrome P450, family 3, subfamily A, polypeptide 4)

apalutamide • cyclosporine • leuprolide acetate for depot suspension

CLEE011O12001: A trial to learn more about the effects of ribociclib taken with endocrine therapy in patients with early breast cancer. (2022-503001-38-01)

P2/3, N=172, Active, not recruiting, Novartis Pharma AG | Recruiting --> Active, not recruiting

9 days ago

Enrollment closed

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor)

ER positive • PGR positive

Kisqali (ribociclib) • letrozole • anastrozole • exemestane • goserelin acetate • leuprolide acetate for depot suspension

17d

UC-BCG-2409/BIG 2402: Evaluating a Personalized Treatment Strategy for Young Women with Early Breast Cancer (2024-519655-28-00)

P2/3, N=2270, Not yet recruiting, Unicancer

17 days ago

New P2/3 trial

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)

HER-2 positive • HR positive • HER-2 negative • HER-2 expression • ER negative

Prosigna™ Breast Cancer Prognostic Gene Signature Assay

paclitaxel • docetaxel • tamoxifen • doxorubicin hydrochloride • cyclophosphamide • letrozole • epirubicin • anastrozole • exemestane • triptorelin • goserelin acetate • leuprolide acetate for depot suspension

17d

UC-BCG-2501: NoLEEta - Phase III non-inferiority trial of chemotherapy de-escalation in hormone receptorpositive, Her2-negative, intermediate-risk early breast cancer treated with Ribociclib (LEE-011) innthe adjuvant setting (2025-520979-13-00)

P2/3, N=3306, Recruiting, Unicancer

17 days ago

New P2/3 trial • Head-to-Head

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor)

ER positive • HER-2 negative • HER-2 negative + ER positive

paclitaxel • docetaxel • doxorubicin hydrochloride • albumin-bound paclitaxel • cyclophosphamide • Kisqali (ribociclib) • letrozole • epirubicin • anastrozole • exemestane • triptorelin • goserelin acetate • leuprolide acetate for depot suspension

19d

A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care. (PubMed, F S Rep)

Of the patients treated for their positive BCL6 results, 20 (86%) were treated with leuprolide acetate, 9 (39%) with an aromatase inhibitor, and 1 (4%) was surgically managed with a laparoscopy in preparation for their frozen embryo transfer...The relationship between BCL6 and endometriosis may not be the golden solution to a single marker focus for testing, or for subsequent therapy planning among infertility patients. Clinicians should be cautious in using single marker testing for diagnosing and treating endometriosis in patients without strong additional therapeutic evidence.

19 days ago

Journal

BCL6 (B-cell CLL/lymphoma 6)

leuprolide acetate for depot suspension

22d

REVELUTION: RElugolix VErsus LeUprolide Cardiac Trial (clinicaltrials.gov)

P2, N=94, Active, not recruiting, Emory University | Trial completion date: Dec 2025 --> Oct 2026

22 days ago

Trial completion date

Orgovyx (relugolix) • leuprolide acetate for depot suspension

29d

CASPAR: A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy (clinicaltrials.gov)

P3, N=61, Active, not recruiting, Alliance for Clinical Trials in Oncology | Trial primary completion date: Mar 2026 --> Mar 2027

29 days ago

Trial primary completion date

Xtandi (enzalutamide) • Rubraca (rucaparib) • goserelin acetate • Firmagon (degarelix) • leuprolide acetate for depot suspension

Study on the Improvement Effect of Probiotics on Perimenopausal Syndrome in Women with Infertility Induced by Leuprolide (ChiCTR2600117205)

P=N/A, N=100, Not yet recruiting, Reproductive Hospital Affiliated to Jiangxi University of Traditional Chinese Medicine; Reproductive Hospital Affiliated to Jiangxi University of Trad

1 month ago

New trial

leuprolide acetate for depot suspension

c15-164: AASUR in High Risk Prostate Cancer (clinicaltrials.gov)

P2, N=64, Completed, Memorial Sloan Kettering Cancer Center | Active, not recruiting --> Completed | Trial completion date: May 2026 --> Jan 2026 | Trial primary completion date: May 2026 --> Jan 2026

1 month ago

Trial completion • Trial completion date • Trial primary completion date

abiraterone acetate • apalutamide • leuprolide acetate for depot suspension