Lymphoma

Although the R-CHOP regimen has significantly improved the prognosis for most patients, a subset continues to experience poor therapeutic outcomes...The key gene TRPV2, associated with favorable prognosis, was found to promote M1-like polarization in monocytes/macrophages and enhance antigen presentation in B cells. This study establishes the NR risk score as a novel prognostic tool for DLBCL and underscores neuro-immune interactions as potential therapeutic targets.

This integrative multi-cohort study uncovered common transcriptional and immune signatures underlying SjD, MALT lymphoma, and thyroid cancer. The identification of shared hub genes, particularly PLA2G7 and TGFB1I1, provides novel insight into the immune-driven transition from chronic inflammation to malignancy and offers promising biomarkers for cross-disease diagnosis and immunotherapeutic stratification. Key Points • Key genes (PLA2G7 and TGFB1I1) affecting the occurrence of Sjögren's syndrome, mucosa-associated lymphoid tissue lymphoma, and thyroid cancer are identified for the first time. • Bioinformatics methods were employed to simultaneously study three diseases for the first time.

Diffuse splenic FDG uptake strongly correlates with systemic inflammation. The SLR emerged as an independent predictor of progression-free survival in our lymphoma cohort. Diffuse bone marrow uptake may involve non-neoplastic factors and requires comprehensive clinicopathological assessment. This study provides new evidence for PET/CT-guided prognostic evaluation in lymphoma.

Our analysis delineates a plausible link between DIGs and DLBCL outcome, nominating CCT5 as environmentally relevant biomarkers with prognostic and potential therapeutic implications.

These findings suggest that C. auriculatum effectively delays reproductive function decline in the testicular tissues of naturally aging rats, likely by inhibiting DNA damage, modulating the P53 signaling pathway, and reducing reproductive cell apoptosis.

Pathology confirmed a mixed ductal-neuroendocrine-acinar cell carcinoma in the pancreas and a diffuse large B-cell lymphoma in the kidney and lymph nodes. Pancreatic MiNEN is an extremely rare disease, accounting for only about 0.2% of all pancreatic tumors.

MALT lymphoma of the gallbladder is rare, does not have typical imaging findings, and preoperative diagnosis is difficult. This case reaffirms the importance of pathological examination of cholecystectomy specimens, as detailed pathological evaluation of the postoperative specimens leads to a diagnosis.

P1, N=20, Recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Mar 2026 --> Mar 2027 | Trial primary completion date: Mar 2026 --> Mar 2027

P2, N=30, Not yet recruiting, The First Affiliated Hospital with Nanjing Medical University

P1, N=17, Active, not recruiting, Byondis B.V. | Recruiting --> Active, not recruiting | N=100 --> 17 | Trial completion date: Dec 2025 --> May 2026 | Trial primary completion date: Oct 2025 --> Feb 2026

P3, N=80, Enrolling by invitation, Second Affiliated Hospital of Nanchang University

P=N/A, N=100, Recruiting, International Extranodal Lymphoma Study Group (IELSG) | Not yet recruiting --> Recruiting