Maxillary Sinus Carcinoma

This case highlights that ectopic maxillary sinus olfactory neuroblastoma can mimic neuroendocrine carcinoma on limited biopsy, emphasizing the importance of complete resection and thorough histopathological evaluation for accurate diagnosis and grading. Hyams grade I disease in atypical locations carries an excellent prognosis with combined endoscopic surgery and radiotherapy, underscoring the prognostic value of Hyams grading and the need for long-term surveillance.

This case illustrates the feasibility of using gadolinium-based contrast agents as an alternative to iodinated contrast media for angiographic guidance during RADPLAT in patients with contraindications to iodinated contrast. However, its long-term safety warrants further investigation.

P1, N=46, Recruiting, National Cancer Institute (NCI) | Trial completion date: Jun 2026 --> Jul 2027 | Trial primary completion date: Jun 2026 --> Jul 2027

In real-world practice, PD-1 inhibitors combined with chemotherapy are an effective and safe treatment option for recurrent/metastatic R/M MSSCC.

The patient was treated with VAC chemotherapy (vincristine, actinomycin D, cyclophosphamide), local radiotherapy (60 Gy), cranial prophylactic radiotherapy (12 Gy), and subsequent debulking surgery. Multimodal treatment incorporating chemotherapy, radiotherapy, surgery, and targeted maintenance therapy can achieve meaningful disease control in aggressive craniofacial MCS. To our knowledge, this represents one of the very few reported pediatric cases of maxillary MCS with confirmed HEY1::NCOA2 fusion managed with sirolimus-based maintenance therapy.

Given unresectability, the patient received toripalimab (240 mg) combined with docetaxel and cisplatin every 3 weeks. To our knowledge, this is the first reported case of toripalimab-based chemoimmunotherapy demonstrating an early partial response and short-term disease control in unresectable maxillary sinus NUT carcinoma. It supports the potential role of PD-1 blockade integrated with platinum-taxane chemotherapy as a component of multimodal management for sinonasal NUT carcinomas.

Surgical resection identified an ectopic ACTH-secreting pituitary adenoma expressing ACTH and T-Pit; a marked decrease in plasma ACTH was observed postoperatively. In conclusion, we report a case of ACTH-dependent Cushing's syndrome, caused by an ectopic corticotroph adenoma located in the maxillary sinus. This case illustrates the diagnostic challenges in localizing ectopic ACTH-secreting pituitary adenomas and highlights the value of nuclear medicine imaging in identifying these unusual lesions.

Corticosteroids appear to be an effective treatment option. Early diagnosis and appropriate steroid therapy may lead to excellent outcomes while avoiding overtreatment.

This study revealed the frequency and prognosis of locally advanced maxillary sinus cancer fed from the ICA. The prognosis was equivalent between cases with or without feeding from the ICA; therefore, it would be considered important to determine the tumor volume for each feeding blood vessel and assess the areas of dual perfusion.

P=N/A, N=16, Completed, Hôpital de la Croix-Rousse

The prognosis of RADPLAT was favorable after 5-year follow-up with acceptable late adverse events and low proportion of treatment related death.

Relevantly, KRT20, KRT5/6, chromogranin A, p40, p63, HMB45, NF, TTF1, TDT (DNTT), PAX5, p16, KIT, as well as high-risk HPV and EBER1/2 (both by ISH), were negative. This report illustrates that a detailed immunohistochemical study, including STAB2 and MCPyV markers, as well as a careful clinical workup, are essential to adequately classify high-grade neuroendocrine carcinomas, especially KRT20-negative MCC.