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    DRUG:

    megestrol

    i
    Other names: BDH 1298
    Company:
    Generic mfg.
    Drug class:
    Progesterone receptor agonist
    Related drugs:
    8d
    Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients (clinicaltrials.gov)
    P3, N=227, Active, not recruiting, Alliance for Clinical Trials in Oncology | Recruiting --> Active, not recruiting | N=360 --> 227
    Enrollment closed • Enrollment change
    |
    megestrol • olanzapine
    9d
    A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015) (clinicaltrials.gov)
    P2, N=250, Recruiting, Merck Sharp & Dohme LLC
    Trial initiation date • Pan tumor
    |
    HER-2 (Human epidermal growth factor receptor 2)
    |
    HR positive • HER-2 negative • EGFR positive
    |
    tamoxifen • fulvestrant • letrozole • exemestane • megestrol • opevesostat (MK-5684)
    13d
    SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer (clinicaltrials.gov)
    P=N/A, N=82, Not yet recruiting, Hospital Universitari de Bellvitge | Trial completion date: Dec 2026 --> Sep 2028 | Initiation date: May 2026 --> Sep 2026 | Trial primary completion date: Jun 2026 --> May 2027
    Trial completion date • Trial initiation date • Trial primary completion date
    |
    TP53 wild-type
    |
    megestrol
    1m
    Megestrol Acetate for First-Line Treatment of Malnourished Non-Small Cell Lung Cancer (clinicaltrials.gov)
    P3, N=116, Not yet recruiting, Hunan Province Tumor Hospital
    New P3 trial
    |
    EGFR (Epidermal growth factor receptor)
    |
    megestrol
    1m
    FEMUS: Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification (clinicaltrials.gov)
    P2/3, N=260, Recruiting, Fudan University | Not yet recruiting --> Recruiting
    Enrollment open • Tumor mutational burden
    |
    PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • MSI (Microsatellite instability) • POLE (DNA Polymerase Epsilon)
    |
    ER positive • MSI-H/dMMR
    |
    Tyvyt (sintilimab) • letrozole • triptorelin • megestrol
    1m
    Long-term control for > 9 years with megestrol acetate-letrozole: metastatic endometrioid carcinoma case report. (PubMed, Front Oncol)
    At last follow-up (OS: 108 months), she maintained SD with minimal toxicity. This is the first case demonstrating that full-dose megestrol acetate plus letrozole may induce durable antitumor activity in HR-high expression metastatic EC, warranting prospective validation.
    Journal
    |
    ER (Estrogen receptor)
    |
    HR positive
    |
    letrozole • megestrol
    1m
    SHAPE-ENDO: Multimodal Pre-Surgical Optimization in Patients With Obesity and Early-Stage Endometrial Cancer (clinicaltrials.gov)
    P=N/A, N=82, Not yet recruiting, Hospital Universitari de Bellvitge
    New trial
    |
    TP53 wild-type
    |
    megestrol
    2ms
    Nano-Megestrol Acetate for Cancer Cachexia in Advanced Pancreatic Cancer (clinicaltrials.gov)
    P=N/A, N=56, Recruiting, Shandong Cancer Hospital and Institute
    New trial
    |
    5-fluorouracil • oxaliplatin • irinotecan • megestrol
    2ms
    Metformin combined with progesterone improves efficacy and reduces adverse reactions in early endometrial cancer. (PubMed, Am J Transl Res)
    Metformin combined with progesterone exerts excellent clinical efficacy in the treatment of early EC. It can significantly reduce serum tumor marker levels and BMI, and decrease the occurrence of adverse reactions.
    Journal
    |
    MMP9 (Matrix metallopeptidase 9) • CTGF (Connective tissue growth factor)
    |
    metformin • megestrol
    2ms
    Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients (clinicaltrials.gov)
    P3, N=360, Recruiting, Alliance for Clinical Trials in Oncology | Trial completion date: Dec 2026 --> Dec 2027 | Trial primary completion date: Apr 2026 --> Apr 2027
    Trial completion date • Trial primary completion date
    |
    megestrol • olanzapine
    3ms
    A prospective, randomized, parallel controlled clinical trial of megestrol acetate oral suspension in patients with locally advanced nasopharyngeal carcinoma (ChiCTR2500114759)
    P=N/A, N=68, Not yet recruiting, Fujian Cancer Hospital; Fujian Cancer Hospital
    New trial
    |
    megestrol • TheraCIM (nimotuzumab)
    3ms
    A Prospective Real-World Observational Study of Nanocrystalline Megestrol Acetate in Patients with Cancer Cachexia (ChiCTR2500112934)
    P=N/A, N=495, Not yet recruiting, Henan Cancer Hospital; Henan Cancer Hospital
    New trial
    |
    megestrol