Melanoma

CBD exhibited strong antitumor activity in melanoma by modulating the PPARγ-TET1 complex to induce demethylation of LRSAM1, thereby suppressing tumor progression. These findings identify CBD as a promising candidate for melanoma therapy.

These findings highlight the promising role of MMP inhibitors in melanoma therapy, suggesting a shift towards more targeted and combinatory treatment strategies. This review aims to provide an up-to-date overview of the advancements and therapeutic prospects of both synthetic and natural MMP inhibitors in melanoma treatment.

P2, N=48, Not yet recruiting, Fudan University

P2, N=30, Recruiting, Vastra Gotaland Region

P=N/A, N=200, Completed, AI Labs Group S.L | Recruiting --> Completed

P2, N=22, Active, not recruiting, Brown University | Trial completion date: Jul 2025 --> Jan 2026

These findings demonstrate that oral L.E.M. activates GALT-mediated DC and CD8+ T-cell responses, thereby augmenting the antitumor immune effects of RT.

Our results reveal that vaccination at the late tumor stage significantly augments the recruitment and immunosuppressive capacity of PMN-MDSCs, driving resistance of advanced tumors to cancer vaccines. The findings demonstrate PMN-MDSCs as critical mediators of vaccine resistance in advanced tumors and highlight modulation of PMN-MDSCs by CD300ld blockade as a promising strategy to enhance the therapeutic efficacy of cancer vaccines, particularly for patients with late-stage malignancies.

P2, N=85, Active, not recruiting, iOnctura | Recruiting --> Active, not recruiting

It underscores that dot-like CK20 and Neurofilament staining are not entirely pathognomonic for MCC diagnosis. In the differential diagnosis of cutaneous round cell tumors, which includes metastases, melanoma, and several sarcoma types, the present case reveals the diagnostic challenges of cutaneous sarcomas and highlights the necessity of a multimodal approach for accurate diagnosis.

The relative levels of E4F1 and IRF2 differ by cell-type and play a role in mediating transcriptional activity in a cell-type specific manner. Our results indicate that the top credible causal set variant rs3769823 likely influences expression of CASP8 and FLACC1 in a cell-type specific manner and may be a relevant functional variant for multiple cancers associated with this locus.

Among mechanisms linked to local immunosuppression, CCN4 knockout has a similar impact on the secretome of both breast cancer and melanoma cell lines. Overall, our results suggest that CCN4 promotes tumor-induced immunosuppression in the context of breast cancer and is a potential target for therapeutic combinations with immunotherapies.