Meningioma

Digital PR H-score assessment confirmed the inverse association between PR expression and WHO grade, as well as its correlation with proliferative activity. Using an FDA-cleared algorithm originally developed for breast carcinoma, this method provides objective and reproducible evaluation in meningiomas.

In this large cohort with extended follow-up, STR patients exhibited a second recurrence peak at 7 to 10 years postoperatively. Adjuvant GKRS showed long-term benefit, supporting its selective use and long-term surveillance beyond 10 years.

This study demonstrates that 99 mTc-HYNIC-octreotide SPECT/CT imaging is an effective method for detecting somatostatin receptor expression in brain tumors, offering a low-cost and accessible alternative to more enhanced imaging techniques, both meningioma and glial tumors express somatostatin receptors, but receptor expression is significantly higher in meningioma.

Our results suggest that MUC4 is associated with higher grades of meningiomas and may have a negative impact on prognosis and recurrence rates, potentially making it a target for an agent with mucolytic effects that can help overcome chemoresistance in aggressive meningiomas. On the other hand, the expression of Caspase-3 correlates with the grade of differentiation and certain histotypes and may be considered as an ideal target for meningioma therapeutic regimens.

Clinically, these tumors display low-grade behavior and DNA methylation profiles consistent with benign subtypes. Our findings identify a meningioma subgroup with distinct genetic, transcriptomic, and clinical features, expanding the molecular classification of meningiomas and opening new avenues for targeted treatment strategies.

P=N/A, N=2500, Recruiting, University Health Network, Toronto | Trial completion date: Jul 2025 --> Jul 2026 | Trial primary completion date: Jul 2025 --> Jul 2026

The co-occurrence of meningiomatosis and isolated hypoglossal nerve palsy in a patient without neurofibromatosis type 2 is exceedingly rare. This case highlights the critical role of advanced imaging in localizing cranial neuropathies and underscores the need to consider meningiomatosis in the differential diagnosis of isolated hypoglossal nerve palsy.

Primary tympanic meningiomas can often be misdiagnosed, particularly when the tympanic membrane is intact. Symptoms such as hearing loss and persistent middle ear effusion may mimic secretory otitis media. Direct examination of the tympanic membrane and prompt imaging, such as computed tomography (CT) scan or magnetic resonance imaging (MRI), are vital for ruling out middle ear lesions and facilitating early intervention. This case report aims to highlight significant causes of unilateral hearing loss that are often overlooked and misclassified as idiopathic sensorineural hearing loss, which otolaryngologists should consider in their evaluations.

Genetic testing characteristically identifies a germline pathogenic variant (often truncating) in the NF2 gene. This review explores the spectrum of clinical disease that arises in NF2-SWN when presenting in childhood.

Further investigation of epithelial-mesenchymal transition (EMT) markers, AKT, and ERK signaling in the 3Fax-treated cell lines revealed that high expression of EMT-related transcription factors (Snail) and EMT-related proteins (MMP9) were regulated via phosphorylation of AKT and ERK. Therefore, the present findings suggested that suppression of sialylation by 3Fax in malignant meningioma increases migration and invasion abilities by enhancing the EMT process.

Based on this the variant is reclassified as likely pathogenic. Moreover, our data suggest that the current ACMG/AMP gene-specific DICER1 guidelines should be modified in relation to the level of evidence strength (moderate to strong/very strong) for exon 22 skipping as well as to the use of the functional evidence (PS3) code.

This study underscores the importance of DNA methylation and transcriptomic profiling in understanding tumor progression and recurrence. While molecular profiling holds promise for prognostication, further research is needed to identify key drivers of MT and clarify their roles in meningioma pathogenesis.